Causes and consequences of obesity: epigenetics or hypokinesis?

Michael R. Graham, Julien S. Baker, Bruce Davies

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Epigenetics can be defined as the study of heritable changes that affect gene function without modification of the deoxyribonucleic acid (DNA) sequence.1 The transfer of epigenetic marks through generations is not well understood, and their transmission is in dispute. Epigenetic marks are tissue-specific and include DNA methylation and histone modifications that mediate biological processes, such as imprinting (Figure 1). Many imprinted genes are regulators of gene expression controlling growth. Imprinting disorders often feature obesity as one of their characteristics.
Original languageEnglish
Pages (from-to)455-460
Number of pages6
JournalDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Publication statusPublished - 2015


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