Causes and consequences of obesity: epigenetics or hypokinesis?

Michael R. Graham; Julien S. Baker; Bruce Davies

doi:10.2147/DMSO.S82629

Causes and consequences of obesity: epigenetics or hypokinesis?

Michael R. Graham, Julien S. Baker, Bruce Davies

School of Health and Life Sciences

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Epigenetics can be defined as the study of heritable changes that affect gene function without modification of the deoxyribonucleic acid (DNA) sequence.1 The transfer of epigenetic marks through generations is not well understood, and their transmission is in dispute. Epigenetic marks are tissue-specific and include DNA methylation and histone modifications that mediate biological processes, such as imprinting (Figure 1). Many imprinted genes are regulators of gene expression controlling growth. Imprinting disorders often feature obesity as one of their characteristics.

Original language	English
Pages (from-to)	455-460
Number of pages	6
Journal	Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Volume	8
DOIs	https://doi.org/10.2147/DMSO.S82629
Publication status	Published - 2015

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10.2147/DMSO.S82629Licence: CC BY-NC

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title = "Causes and consequences of obesity: epigenetics or hypokinesis?",

abstract = "Epigenetics can be defined as the study of heritable changes that affect gene function without modification of the deoxyribonucleic acid (DNA) sequence.1 The transfer of epigenetic marks through generations is not well understood, and their transmission is in dispute. Epigenetic marks are tissue-specific and include DNA methylation and histone modifications that mediate biological processes, such as imprinting (Figure 1). Many imprinted genes are regulators of gene expression controlling growth. Imprinting disorders often feature obesity as one of their characteristics.",

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AB - Epigenetics can be defined as the study of heritable changes that affect gene function without modification of the deoxyribonucleic acid (DNA) sequence.1 The transfer of epigenetic marks through generations is not well understood, and their transmission is in dispute. Epigenetic marks are tissue-specific and include DNA methylation and histone modifications that mediate biological processes, such as imprinting (Figure 1). Many imprinted genes are regulators of gene expression controlling growth. Imprinting disorders often feature obesity as one of their characteristics.

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ER -

Causes and consequences of obesity: epigenetics or hypokinesis?

Abstract

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