Cardiorespiratory fitness and bone turnover markers in adults with metabolic syndrome: the mediator role of inflammation

José J. Gil-Cosano, Luis Gracia-Marco*, Daniel Courteix, Bruno Lesourd, Robert Chapier, Philippe Obert, Guillaume Walther, Agnes Vinet, David Thivel, Manuel Muñoz-Torres, Ukadike C. Ugbolue, Reza Bagheri, Marek Zak, Frédéric Dutheil, Esther Ubago-Guisado

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
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Abstract

The relationship between inflammatory markers and bone turnover in adults is well known, and a negative association between cardiorespiratory fitness (CRF) and inflammatory markers has also been described. Hence, we tested whether the association between CRF and bone turnover markers is mediated by inflammatory markers in adults with metabolic syndrome. A total of 81 adults (58.5 ± 5.0 years, 62.7% women) were included in the analysis. CRF was measured by the 6-min walking test. Serum interleukin (IL)-1β, IL-6, IL-10, tumor necrosis factor alpha, high-sensitivity c-reactive protein (hsCRP) and vascular endothelial growth factor, collagen type I cross-linked C-telopeptide, procollagen type I N-terminal propeptide (P1NP), and total osteocalcin were assessed using a sensitive ELISA kit. Body composition was assessed by dual-energy X-ray absorptiometry. Partial correlation was used to test the relationship between CRF, inflammatory markers, and bone turnover markers, controlling for sex, lean mass, and fat mass. Boot-strapped mediation procedures were performed, and indirect effects with confidence intervals not including zero were interpreted as statistically significant. CRF was positively correlated with P1NP levels (r = .228, p = .044) and osteocalcin levels (r = .296, p = .009). Furthermore, CRF was positively correlated with IL-1β levels (r = .340, p = .002) and negatively correlated with hsCRP levels (r = −.335, p = .003), whereas IL-1β levels were positively correlated with P1NP levels (r = .245, p = .030), and hsCRP levels were negatively correlated with P1NP levels (r = −.319, p = .004). Finally, the association between CRF and P1NP levels was totally mediated by hsCRP (percentage of mediation = 39.9). Therefore, CRF benefits on bone formation could be dependent on hsCRP concentrations in this population.
Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalInternational Journal of Sport Nutrition and Exercise Metabolism
Volume33
Issue number1
Early online date21 Oct 2022
DOIs
Publication statusPublished - 31 Jan 2023

Keywords

  • aerobic fitnes
  • bone metabolism
  • immunology
  • obesity

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