Cardiopulmonary rehabilitation enhances heart rate recovery in patients with COPD

Vasiliki V. Georgiopoulou, Stavros Dimopoulos, Dimitrios Sakellariou, Ourania Papazachou, Vasiliki Gerovasili, Athanasios Tasoulis, Varvara Agapitou, Ioannis Vogiatzis, Charis Roussos, Serafim Nanas

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Autonomic dysfunction is present early in the course of COPD, and is associated with adverse outcomes. We utilized heart rate recovery, a simple and validated index of autonomic balance, to investigate the effects of exercise training on autonomic dysfunction in patients with COPD.
METHODS: We evaluated 45 stable subjects with COPD who participated in a 36-session exercise-based cardiopulmonary rehabilitation program. Subjects underwent maximal cardiopulmonary exercise testing at baseline and after completion of the rehabilitation program. We recorded exercise testing parameters and heart rate during rest, exercise, and recovery. Heart rate recovery was calculated as heart rate at peak exercise minus heart rate at the first minute of recovery.
RESULTS: Thirty-nine subjects (age 66.3 +/- 7.8 y, 90% male, body mass index 27.1 +/- 4.1 kg/m(2), FEV1 45.7 +/- 18.7%) completed the program. In these subjects, heart rate recovery increased from 16.2 +/- 8.0 beats/min to 18.4 +/- 8.4 beats/min (P = .01), resting heart rate decreased from 88.0 +/- 10.7 beats/min to 83.3 +/- 10.5 beats/min (P = .004), and heart rate at anaerobic threshold decreased from 109.0 +/- 12.5 beats/min to 105.5 +/- 11.7 beats/min (P = .040). In addition, oxygen consumption ((V) over dot(O2)) increased from 14.3 +/- 3.7 mL/kg/min to 15.2 +/- 3.8 mL/kg/min at peak exercise, and from 9.7 +/- 2.4 mL/kg/min to 10.4 +/- 2.6 mL/kg/min at anaerobic threshold (both P = .02), while the (V) over dot(O2)/t slope increased from -0.32 +/- 0.16 mL/kg/min(2) to -0.38 +/- 0.19 mL/kg/min(2) (P = .003). Parameters of ventilatory performance improved also.
CONCLUSIONS: In subjects with COPD, exercise-based rehabilitation improves heart rate recovery, modestly though, which indicates a degree of attenuated autonomic dysfunction. Exercise and muscular oxidative capacity, as expressed by (V) over dot(O2)/t slope, is also improved.
Original languageEnglish
Pages (from-to)2095-2103
Number of pages9
JournalRespiratory Care
Volume57
Issue number12
Publication statusPublished - Dec 2012
Externally publishedYes

Keywords

  • autonomic nervous system
  • ergometry/exercise test
  • heart rate
  • COPD
  • rehabilitation/exercise therapy

Cite this

Georgiopoulou, V. V., Dimopoulos, S., Sakellariou, D., Papazachou, O., Gerovasili, V., Tasoulis, A., ... Nanas, S. (2012). Cardiopulmonary rehabilitation enhances heart rate recovery in patients with COPD. Respiratory Care, 57(12), 2095-2103.
Georgiopoulou, Vasiliki V. ; Dimopoulos, Stavros ; Sakellariou, Dimitrios ; Papazachou, Ourania ; Gerovasili, Vasiliki ; Tasoulis, Athanasios ; Agapitou, Varvara ; Vogiatzis, Ioannis ; Roussos, Charis ; Nanas, Serafim. / Cardiopulmonary rehabilitation enhances heart rate recovery in patients with COPD. In: Respiratory Care. 2012 ; Vol. 57, No. 12. pp. 2095-2103.
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Georgiopoulou, VV, Dimopoulos, S, Sakellariou, D, Papazachou, O, Gerovasili, V, Tasoulis, A, Agapitou, V, Vogiatzis, I, Roussos, C & Nanas, S 2012, 'Cardiopulmonary rehabilitation enhances heart rate recovery in patients with COPD' Respiratory Care, vol. 57, no. 12, pp. 2095-2103.

Cardiopulmonary rehabilitation enhances heart rate recovery in patients with COPD. / Georgiopoulou, Vasiliki V.; Dimopoulos, Stavros; Sakellariou, Dimitrios; Papazachou, Ourania; Gerovasili, Vasiliki; Tasoulis, Athanasios; Agapitou, Varvara; Vogiatzis, Ioannis; Roussos, Charis; Nanas, Serafim.

In: Respiratory Care, Vol. 57, No. 12, 12.2012, p. 2095-2103.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cardiopulmonary rehabilitation enhances heart rate recovery in patients with COPD

AU - Georgiopoulou, Vasiliki V.

AU - Dimopoulos, Stavros

AU - Sakellariou, Dimitrios

AU - Papazachou, Ourania

AU - Gerovasili, Vasiliki

AU - Tasoulis, Athanasios

AU - Agapitou, Varvara

AU - Vogiatzis, Ioannis

AU - Roussos, Charis

AU - Nanas, Serafim

PY - 2012/12

Y1 - 2012/12

N2 - BACKGROUND: Autonomic dysfunction is present early in the course of COPD, and is associated with adverse outcomes. We utilized heart rate recovery, a simple and validated index of autonomic balance, to investigate the effects of exercise training on autonomic dysfunction in patients with COPD. METHODS: We evaluated 45 stable subjects with COPD who participated in a 36-session exercise-based cardiopulmonary rehabilitation program. Subjects underwent maximal cardiopulmonary exercise testing at baseline and after completion of the rehabilitation program. We recorded exercise testing parameters and heart rate during rest, exercise, and recovery. Heart rate recovery was calculated as heart rate at peak exercise minus heart rate at the first minute of recovery. RESULTS: Thirty-nine subjects (age 66.3 +/- 7.8 y, 90% male, body mass index 27.1 +/- 4.1 kg/m(2), FEV1 45.7 +/- 18.7%) completed the program. In these subjects, heart rate recovery increased from 16.2 +/- 8.0 beats/min to 18.4 +/- 8.4 beats/min (P = .01), resting heart rate decreased from 88.0 +/- 10.7 beats/min to 83.3 +/- 10.5 beats/min (P = .004), and heart rate at anaerobic threshold decreased from 109.0 +/- 12.5 beats/min to 105.5 +/- 11.7 beats/min (P = .040). In addition, oxygen consumption ((V) over dot(O2)) increased from 14.3 +/- 3.7 mL/kg/min to 15.2 +/- 3.8 mL/kg/min at peak exercise, and from 9.7 +/- 2.4 mL/kg/min to 10.4 +/- 2.6 mL/kg/min at anaerobic threshold (both P = .02), while the (V) over dot(O2)/t slope increased from -0.32 +/- 0.16 mL/kg/min(2) to -0.38 +/- 0.19 mL/kg/min(2) (P = .003). Parameters of ventilatory performance improved also. CONCLUSIONS: In subjects with COPD, exercise-based rehabilitation improves heart rate recovery, modestly though, which indicates a degree of attenuated autonomic dysfunction. Exercise and muscular oxidative capacity, as expressed by (V) over dot(O2)/t slope, is also improved.

AB - BACKGROUND: Autonomic dysfunction is present early in the course of COPD, and is associated with adverse outcomes. We utilized heart rate recovery, a simple and validated index of autonomic balance, to investigate the effects of exercise training on autonomic dysfunction in patients with COPD. METHODS: We evaluated 45 stable subjects with COPD who participated in a 36-session exercise-based cardiopulmonary rehabilitation program. Subjects underwent maximal cardiopulmonary exercise testing at baseline and after completion of the rehabilitation program. We recorded exercise testing parameters and heart rate during rest, exercise, and recovery. Heart rate recovery was calculated as heart rate at peak exercise minus heart rate at the first minute of recovery. RESULTS: Thirty-nine subjects (age 66.3 +/- 7.8 y, 90% male, body mass index 27.1 +/- 4.1 kg/m(2), FEV1 45.7 +/- 18.7%) completed the program. In these subjects, heart rate recovery increased from 16.2 +/- 8.0 beats/min to 18.4 +/- 8.4 beats/min (P = .01), resting heart rate decreased from 88.0 +/- 10.7 beats/min to 83.3 +/- 10.5 beats/min (P = .004), and heart rate at anaerobic threshold decreased from 109.0 +/- 12.5 beats/min to 105.5 +/- 11.7 beats/min (P = .040). In addition, oxygen consumption ((V) over dot(O2)) increased from 14.3 +/- 3.7 mL/kg/min to 15.2 +/- 3.8 mL/kg/min at peak exercise, and from 9.7 +/- 2.4 mL/kg/min to 10.4 +/- 2.6 mL/kg/min at anaerobic threshold (both P = .02), while the (V) over dot(O2)/t slope increased from -0.32 +/- 0.16 mL/kg/min(2) to -0.38 +/- 0.19 mL/kg/min(2) (P = .003). Parameters of ventilatory performance improved also. CONCLUSIONS: In subjects with COPD, exercise-based rehabilitation improves heart rate recovery, modestly though, which indicates a degree of attenuated autonomic dysfunction. Exercise and muscular oxidative capacity, as expressed by (V) over dot(O2)/t slope, is also improved.

KW - autonomic nervous system

KW - ergometry/exercise test

KW - heart rate

KW - COPD

KW - rehabilitation/exercise therapy

M3 - Article

VL - 57

SP - 2095

EP - 2103

JO - Respiratory Care

JF - Respiratory Care

SN - 0020-1324

IS - 12

ER -

Georgiopoulou VV, Dimopoulos S, Sakellariou D, Papazachou O, Gerovasili V, Tasoulis A et al. Cardiopulmonary rehabilitation enhances heart rate recovery in patients with COPD. Respiratory Care. 2012 Dec;57(12):2095-2103.