Can the legacy of industrial pollution influence antimicrobial resistance in estuarine sediments?

Kiri Rodgers, Iain McLellan, Tatyana Peshkur, Roderick Williams, Rebecca Tonner, Andrew Hursthouse, Charles Knapp, Fiona Henriquez

Research output: Contribution to journalLiterature review

6 Citations (Scopus)
67 Downloads (Pure)

Abstract

Antimicrobial resistance (AMR) represents a major global health threat, as well as a major hazard to sustainable economic development and national security. It remains, therefore, vital that current research aligns to policy development and implementation to alleviate a potential crisis. One must consider, for example, whether drivers of antibiotic resistance can be controlled in the future, or have they already accumulated in the past? Whether from antibiotics and/or other pollutants. Unfortunately, industrial heritage and its pollution impact on the prevalence of environmental AMR have largely been ignored. Focussing on industrialised estuaries we demonstrate that anthropogenic pollution inputs in addition to the natural diurnal environmental conditions can sufficiently create stressful conditions to the microbiome, and thus promote selective pressures to shift the resistome (i.e., collection of resistance traits in the microbiological community). Unfortunately, the bacteria’s survival mechanisms, via co-selective pressures, can affect their susceptibility to antibiotics. This review highlights the complexity of estuarine environments, using two key contaminant groups (Metals/toxic elements and polyaromatic hydrocarbons), through which a variety of possible chemical and biological pollutant stressors can promote the emergence and dissemination of antimicrobial resistance. We find compelling divers to call on more focused research on historically disrupted ecosystems, in propagating AMR in the real world.
Original languageEnglish
Pages (from-to)595-607
Number of pages13
JournalEnvironmental Chemistry Letters
Volume17
Issue number2
Early online date13 Oct 2018
DOIs
Publication statusE-pub ahead of print - 13 Oct 2018

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estuarine sediment
antibiotics
Sediments
Pollution
Security Measures
Anti-Bacterial Agents
chemical pollutant
Estuaries
pollution
national security
Economic Development
antibiotic resistance
pollutant
Policy Making
Poisons
estuarine environment
Microbiota
Conservation of Natural Resources
Microbial Drug Resistance
Hydrocarbons

Keywords

  • Antimicrobial resistance
  • Microbiome
  • RESISTANCE
  • Resistant genes
  • industrial pollution
  • Metals
  • Polyaromatic hydrcarbons
  • Environment and human health
  • Environmental impacts
  • waste management
  • Antibiotic resistance
  • Immunology
  • Legacy Pollution
  • Environmental geochemistry
  • Geochemistry
  • Microgeochemistry

Cite this

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title = "Can the legacy of industrial pollution influence antimicrobial resistance in estuarine sediments?",
abstract = "Antimicrobial resistance (AMR) represents a major global health threat, as well as a major hazard to sustainable economic development and national security. It remains, therefore, vital that current research aligns to policy development and implementation to alleviate a potential crisis. One must consider, for example, whether drivers of antibiotic resistance can be controlled in the future, or have they already accumulated in the past? Whether from antibiotics and/or other pollutants. Unfortunately, industrial heritage and its pollution impact on the prevalence of environmental AMR have largely been ignored. Focussing on industrialised estuaries we demonstrate that anthropogenic pollution inputs in addition to the natural diurnal environmental conditions can sufficiently create stressful conditions to the microbiome, and thus promote selective pressures to shift the resistome (i.e., collection of resistance traits in the microbiological community). Unfortunately, the bacteria’s survival mechanisms, via co-selective pressures, can affect their susceptibility to antibiotics. This review highlights the complexity of estuarine environments, using two key contaminant groups (Metals/toxic elements and polyaromatic hydrocarbons), through which a variety of possible chemical and biological pollutant stressors can promote the emergence and dissemination of antimicrobial resistance. We find compelling divers to call on more focused research on historically disrupted ecosystems, in propagating AMR in the real world.",
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Can the legacy of industrial pollution influence antimicrobial resistance in estuarine sediments? / Rodgers, Kiri; McLellan, Iain; Peshkur, Tatyana; Williams, Roderick; Tonner, Rebecca ; Hursthouse, Andrew; Knapp, Charles; Henriquez, Fiona .

In: Environmental Chemistry Letters, Vol. 17, No. 2, 13.10.2018, p. 595-607.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - Can the legacy of industrial pollution influence antimicrobial resistance in estuarine sediments?

AU - Rodgers, Kiri

AU - McLellan, Iain

AU - Peshkur, Tatyana

AU - Williams, Roderick

AU - Tonner, Rebecca

AU - Hursthouse, Andrew

AU - Knapp, Charles

AU - Henriquez, Fiona

PY - 2018/10/13

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N2 - Antimicrobial resistance (AMR) represents a major global health threat, as well as a major hazard to sustainable economic development and national security. It remains, therefore, vital that current research aligns to policy development and implementation to alleviate a potential crisis. One must consider, for example, whether drivers of antibiotic resistance can be controlled in the future, or have they already accumulated in the past? Whether from antibiotics and/or other pollutants. Unfortunately, industrial heritage and its pollution impact on the prevalence of environmental AMR have largely been ignored. Focussing on industrialised estuaries we demonstrate that anthropogenic pollution inputs in addition to the natural diurnal environmental conditions can sufficiently create stressful conditions to the microbiome, and thus promote selective pressures to shift the resistome (i.e., collection of resistance traits in the microbiological community). Unfortunately, the bacteria’s survival mechanisms, via co-selective pressures, can affect their susceptibility to antibiotics. This review highlights the complexity of estuarine environments, using two key contaminant groups (Metals/toxic elements and polyaromatic hydrocarbons), through which a variety of possible chemical and biological pollutant stressors can promote the emergence and dissemination of antimicrobial resistance. We find compelling divers to call on more focused research on historically disrupted ecosystems, in propagating AMR in the real world.

AB - Antimicrobial resistance (AMR) represents a major global health threat, as well as a major hazard to sustainable economic development and national security. It remains, therefore, vital that current research aligns to policy development and implementation to alleviate a potential crisis. One must consider, for example, whether drivers of antibiotic resistance can be controlled in the future, or have they already accumulated in the past? Whether from antibiotics and/or other pollutants. Unfortunately, industrial heritage and its pollution impact on the prevalence of environmental AMR have largely been ignored. Focussing on industrialised estuaries we demonstrate that anthropogenic pollution inputs in addition to the natural diurnal environmental conditions can sufficiently create stressful conditions to the microbiome, and thus promote selective pressures to shift the resistome (i.e., collection of resistance traits in the microbiological community). Unfortunately, the bacteria’s survival mechanisms, via co-selective pressures, can affect their susceptibility to antibiotics. This review highlights the complexity of estuarine environments, using two key contaminant groups (Metals/toxic elements and polyaromatic hydrocarbons), through which a variety of possible chemical and biological pollutant stressors can promote the emergence and dissemination of antimicrobial resistance. We find compelling divers to call on more focused research on historically disrupted ecosystems, in propagating AMR in the real world.

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KW - RESISTANCE

KW - Resistant genes

KW - industrial pollution

KW - Metals

KW - Polyaromatic hydrcarbons

KW - Environment and human health

KW - Environmental impacts

KW - waste management

KW - Antibiotic resistance

KW - Immunology

KW - Legacy Pollution

KW - Environmental geochemistry

KW - Geochemistry

KW - Microgeochemistry

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DO - 10.1007/s10311-018-0791-y

M3 - Literature review

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SP - 595

EP - 607

JO - Environmental Chemistry Letters

JF - Environmental Chemistry Letters

SN - 1610-3653

IS - 2

ER -