C-reactive protein in schoolchildren and its relation to adiposity, physical activity, aerobic fitness and habitual diet

N.-E. Thomas, J.S. Baker, M.R. Graham, S.-M. Cooper, B. Davies

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective
To investigate the relation between C-reactive protein (CRP), adiposity, physical activity, aerobic fitness and habitual diet in a cohort of schoolchildren.

Methods

A cross-sectional study of 164 schoolchildren aged 12–13 years was conducted in two schools. Adiposity was estimated using body mass index and waist circumference. Blood samples were taken after an overnight fast and measured for CRP. Aerobic fitness and habitual physical activity were assessed using the 20 metres multistage fitness test, and a seven-day recall, respectively. A seven-day food diary provided measures of dietary intake.

Results
To improve the distribution of this variable, CRP levels were logarithmically transformed in all analyses. There was no significant difference in mean CRP concentration between boys (1.07 (1.33) mg/l) and girls (1.24 (1.87) mg/l) (p⩾0.05). Compared to girls, boys reported significantly higher (i) aerobic fitness 59.2 (20.3) shuttles vs 42.9 (15.3) shuttles, (ii) vigorous activity levels per week 92 (123) minutes vs 11.2 (34.6) minutes and (iii) waist circumference 69.8 (1.1) cm vs 65.2 (0.9) cm (p⩽0.05). Among boys and girls, adiposity was significantly associated with log transformed CRP (p⩽0.05). CRP was not significantly related to any other variable.

Conclusion

Elevated CRP was evident in this cohort; however, whether high CRP levels during childhood and adolescence leads to an increased risk of CVD in later life has not been determined. Adiposity was related to CRP concentration, suggesting that reducing adiposity may be effective in lowering CRP and preventing future cardiovascular events.
Original languageEnglish
Pages (from-to)357-360
Number of pages4
JournalBritish Journal of Sports Medicine
Volume42
Issue number5
DOIs
Publication statusPublished - 1 May 2008
Externally publishedYes

Fingerprint

Adiposity
C-Reactive Protein
Exercise
Diet
Waist Circumference
Diet Records
Body Mass Index
Cross-Sectional Studies

Cite this

Thomas, N.-E. ; Baker, J.S. ; Graham, M.R. ; Cooper, S.-M. ; Davies, B. / C-reactive protein in schoolchildren and its relation to adiposity, physical activity, aerobic fitness and habitual diet. In: British Journal of Sports Medicine. 2008 ; Vol. 42, No. 5. pp. 357-360.
@article{7d4f3c7d61f74739818f91b35eaae3c9,
title = "C-reactive protein in schoolchildren and its relation to adiposity, physical activity, aerobic fitness and habitual diet",
abstract = "ObjectiveTo investigate the relation between C-reactive protein (CRP), adiposity, physical activity, aerobic fitness and habitual diet in a cohort of schoolchildren.MethodsA cross-sectional study of 164 schoolchildren aged 12–13 years was conducted in two schools. Adiposity was estimated using body mass index and waist circumference. Blood samples were taken after an overnight fast and measured for CRP. Aerobic fitness and habitual physical activity were assessed using the 20 metres multistage fitness test, and a seven-day recall, respectively. A seven-day food diary provided measures of dietary intake.ResultsTo improve the distribution of this variable, CRP levels were logarithmically transformed in all analyses. There was no significant difference in mean CRP concentration between boys (1.07 (1.33) mg/l) and girls (1.24 (1.87) mg/l) (p⩾0.05). Compared to girls, boys reported significantly higher (i) aerobic fitness 59.2 (20.3) shuttles vs 42.9 (15.3) shuttles, (ii) vigorous activity levels per week 92 (123) minutes vs 11.2 (34.6) minutes and (iii) waist circumference 69.8 (1.1) cm vs 65.2 (0.9) cm (p⩽0.05). Among boys and girls, adiposity was significantly associated with log transformed CRP (p⩽0.05). CRP was not significantly related to any other variable.ConclusionElevated CRP was evident in this cohort; however, whether high CRP levels during childhood and adolescence leads to an increased risk of CVD in later life has not been determined. Adiposity was related to CRP concentration, suggesting that reducing adiposity may be effective in lowering CRP and preventing future cardiovascular events.",
author = "N.-E. Thomas and J.S. Baker and M.R. Graham and S.-M. Cooper and B. Davies",
year = "2008",
month = "5",
day = "1",
doi = "10.1136/bjsm.2007.043604",
language = "English",
volume = "42",
pages = "357--360",
journal = "British Journal of Sports Medicine",
issn = "0306-3674",
publisher = "BMJ Publishing Group",
number = "5",

}

C-reactive protein in schoolchildren and its relation to adiposity, physical activity, aerobic fitness and habitual diet. / Thomas, N.-E.; Baker, J.S.; Graham, M.R.; Cooper, S.-M. ; Davies, B.

In: British Journal of Sports Medicine, Vol. 42, No. 5, 01.05.2008, p. 357-360.

Research output: Contribution to journalArticle

TY - JOUR

T1 - C-reactive protein in schoolchildren and its relation to adiposity, physical activity, aerobic fitness and habitual diet

AU - Thomas, N.-E.

AU - Baker, J.S.

AU - Graham, M.R.

AU - Cooper, S.-M.

AU - Davies, B.

PY - 2008/5/1

Y1 - 2008/5/1

N2 - ObjectiveTo investigate the relation between C-reactive protein (CRP), adiposity, physical activity, aerobic fitness and habitual diet in a cohort of schoolchildren.MethodsA cross-sectional study of 164 schoolchildren aged 12–13 years was conducted in two schools. Adiposity was estimated using body mass index and waist circumference. Blood samples were taken after an overnight fast and measured for CRP. Aerobic fitness and habitual physical activity were assessed using the 20 metres multistage fitness test, and a seven-day recall, respectively. A seven-day food diary provided measures of dietary intake.ResultsTo improve the distribution of this variable, CRP levels were logarithmically transformed in all analyses. There was no significant difference in mean CRP concentration between boys (1.07 (1.33) mg/l) and girls (1.24 (1.87) mg/l) (p⩾0.05). Compared to girls, boys reported significantly higher (i) aerobic fitness 59.2 (20.3) shuttles vs 42.9 (15.3) shuttles, (ii) vigorous activity levels per week 92 (123) minutes vs 11.2 (34.6) minutes and (iii) waist circumference 69.8 (1.1) cm vs 65.2 (0.9) cm (p⩽0.05). Among boys and girls, adiposity was significantly associated with log transformed CRP (p⩽0.05). CRP was not significantly related to any other variable.ConclusionElevated CRP was evident in this cohort; however, whether high CRP levels during childhood and adolescence leads to an increased risk of CVD in later life has not been determined. Adiposity was related to CRP concentration, suggesting that reducing adiposity may be effective in lowering CRP and preventing future cardiovascular events.

AB - ObjectiveTo investigate the relation between C-reactive protein (CRP), adiposity, physical activity, aerobic fitness and habitual diet in a cohort of schoolchildren.MethodsA cross-sectional study of 164 schoolchildren aged 12–13 years was conducted in two schools. Adiposity was estimated using body mass index and waist circumference. Blood samples were taken after an overnight fast and measured for CRP. Aerobic fitness and habitual physical activity were assessed using the 20 metres multistage fitness test, and a seven-day recall, respectively. A seven-day food diary provided measures of dietary intake.ResultsTo improve the distribution of this variable, CRP levels were logarithmically transformed in all analyses. There was no significant difference in mean CRP concentration between boys (1.07 (1.33) mg/l) and girls (1.24 (1.87) mg/l) (p⩾0.05). Compared to girls, boys reported significantly higher (i) aerobic fitness 59.2 (20.3) shuttles vs 42.9 (15.3) shuttles, (ii) vigorous activity levels per week 92 (123) minutes vs 11.2 (34.6) minutes and (iii) waist circumference 69.8 (1.1) cm vs 65.2 (0.9) cm (p⩽0.05). Among boys and girls, adiposity was significantly associated with log transformed CRP (p⩽0.05). CRP was not significantly related to any other variable.ConclusionElevated CRP was evident in this cohort; however, whether high CRP levels during childhood and adolescence leads to an increased risk of CVD in later life has not been determined. Adiposity was related to CRP concentration, suggesting that reducing adiposity may be effective in lowering CRP and preventing future cardiovascular events.

U2 - 10.1136/bjsm.2007.043604

DO - 10.1136/bjsm.2007.043604

M3 - Article

VL - 42

SP - 357

EP - 360

JO - British Journal of Sports Medicine

JF - British Journal of Sports Medicine

SN - 0306-3674

IS - 5

ER -