Bioactive diterpene derivatives from the marine sponge spongionella sp.

Mostafa E. Rateb, Wael E. Houssen, Marc Schumacher, William T. A. Harrison, Marc Diederich, Rainer Ebel, Marcel Jaspars

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


Three new compounds of the rare classes trisnorditerpenes, bisnorditerpenes, and norditerpenes, gracilins J−L (1, 2, 6), and a new diterpene, 3′-norspongiolactone (8), were isolated from the extract of the marine sponge Spongionella sp. using NMR- and bioassay-guided fractionation, in addition to three known gracilins (3−5) as well as the known diterpenoid tetrahydroaplysulphurin-1 (7). The structures were elucidated using NMR spectroscopic techniques and mass spectrometric analysis. The structure of gracilin H (3) was confirmed by single-crystal X-ray analysis. All compounds were tested for their cytotoxicity and for their potential to inhibit EGF-R tyrosine kinase.
Original languageEnglish
Pages (from-to)1471-1476
Number of pages6
JournalJournal of Natural Products
Issue number8
Publication statusPublished - 14 Jul 2009
Externally publishedYes


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