Aspergillus biofilms in human disease

Craig Williams, Ranjith Rajendran, Gordon Ramage

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)

Abstract

The biofilm phenotype of Aspergillus species is an important and accepted clinical entity. While industrially these biofilms have been used extensively in important biofermentations, their role in clinical infection is less well defined. A recent flurry of activity has demonstrated that these interesting filamentous moulds have the capacity to form biofilms both in vitro and in vivo, and through various investigations have shown that these are exquisitely resistant to antifungal therapies through a range of adaptive resistance mechanisms independent of defined genetic changes. This review will explore the clinical importance of these biofilms and provide contemporary information with respect to their clinical management.
Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Place of PublicationBoston, MA
PublisherSpringer
Pages1-11
Number of pages11
Volume3
DOIs
Publication statusPublished - 7 Jun 2016

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer US
Volume931
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

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Keywords

  • Aspergillus biofilm
  • Filamentous moulds
  • Fungal infections
  • Aspergillosis
  • Antifungal drugs

Cite this

Williams, C., Rajendran, R., & Ramage, G. (2016). Aspergillus biofilms in human disease. In Advances in Experimental Medicine and Biology (Vol. 3, pp. 1-11). (Advances in Experimental Medicine and Biology; Vol. 931). Springer. https://doi.org/10.1007/5584_2016_4