Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil

Mohamed S.A. Abdelkader; Thomas Philippon; Juan A. Asenjo; Alan T. Bull; Michael Goodfellow; Rainer Ebel; Marcel Jaspars; Mostafa E. Rateb

doi:10.1038/s41429-017-0012-0

Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil

Mohamed S.A. Abdelkader, Thomas Philippon, Juan A. Asenjo, Alan T. Bull, Michael Goodfellow, Rainer Ebel, Marcel Jaspars, Mostafa E. Rateb^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Bio-guided fractionation of the culture broth extract of Streptomyces asenjonii strain KNN 42.f recovered from an extreme hyper-arid Atacama Desert soil in northern Chile led to the isolation of three new bioactive β-diketones; asenjonamides A-C (1-3) in addition to the known N-(2-(1H-indol-3-yl)-2-oxoethyl)acetamide (4), a series of bioactive acylated 4-aminoheptosyl-β-N-glycosides; spicamycins A-E (5-9), and seven known diketopiperazines (10-16). All isolated compounds were characterized by HRESIMS and NMR analyses and tested for their antibacterial effect against a panel of bacteria.

Original language	English
Pages (from-to)	425-431
Number of pages	7
Journal	The Journal of Antibiotics
Volume	71
Early online date	23 Jan 2018
DOIs	https://doi.org/10.1038/s41429-017-0012-0
Publication status	E-pub ahead of print - 23 Jan 2018

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2017 11 02 Abdelkader et al Asenjonamides acceptedAccepted author manuscript, 189 KBLicence: CC BY-NC-ND

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Abdelkader, M. S. A., Philippon, T., Asenjo, J. A., Bull, A. T., Goodfellow, M., Ebel, R., Jaspars, M., & Rateb, M. E. (2018). Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil. The Journal of Antibiotics, 71, 425-431. Advance online publication. https://doi.org/10.1038/s41429-017-0012-0

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abstract = "Bio-guided fractionation of the culture broth extract of Streptomyces asenjonii strain KNN 42.f recovered from an extreme hyper-arid Atacama Desert soil in northern Chile led to the isolation of three new bioactive β-diketones; asenjonamides A-C (1-3) in addition to the known N-(2-(1H-indol-3-yl)-2-oxoethyl)acetamide (4), a series of bioactive acylated 4-aminoheptosyl-β-N-glycosides; spicamycins A-E (5-9), and seven known diketopiperazines (10-16). All isolated compounds were characterized by HRESIMS and NMR analyses and tested for their antibacterial effect against a panel of bacteria.",

author = "Abdelkader, {Mohamed S.A.} and Thomas Philippon and Asenjo, {Juan A.} and Bull, {Alan T.} and Michael Goodfellow and Rainer Ebel and Marcel Jaspars and Rateb, {Mostafa E.}",

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doi = "10.1038/s41429-017-0012-0",

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AU - Abdelkader, Mohamed S.A.

AU - Philippon, Thomas

AU - Asenjo, Juan A.

AU - Bull, Alan T.

AU - Goodfellow, Michael

AU - Ebel, Rainer

AU - Jaspars, Marcel

AU - Rateb, Mostafa E.

PY - 2018/1/23

Y1 - 2018/1/23

N2 - Bio-guided fractionation of the culture broth extract of Streptomyces asenjonii strain KNN 42.f recovered from an extreme hyper-arid Atacama Desert soil in northern Chile led to the isolation of three new bioactive β-diketones; asenjonamides A-C (1-3) in addition to the known N-(2-(1H-indol-3-yl)-2-oxoethyl)acetamide (4), a series of bioactive acylated 4-aminoheptosyl-β-N-glycosides; spicamycins A-E (5-9), and seven known diketopiperazines (10-16). All isolated compounds were characterized by HRESIMS and NMR analyses and tested for their antibacterial effect against a panel of bacteria.

AB - Bio-guided fractionation of the culture broth extract of Streptomyces asenjonii strain KNN 42.f recovered from an extreme hyper-arid Atacama Desert soil in northern Chile led to the isolation of three new bioactive β-diketones; asenjonamides A-C (1-3) in addition to the known N-(2-(1H-indol-3-yl)-2-oxoethyl)acetamide (4), a series of bioactive acylated 4-aminoheptosyl-β-N-glycosides; spicamycins A-E (5-9), and seven known diketopiperazines (10-16). All isolated compounds were characterized by HRESIMS and NMR analyses and tested for their antibacterial effect against a panel of bacteria.

U2 - 10.1038/s41429-017-0012-0

DO - 10.1038/s41429-017-0012-0

M3 - Article

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SN - 0021-8820

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SP - 425

EP - 431

JO - The Journal of Antibiotics

JF - The Journal of Antibiotics

ER -

Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil

Abstract

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