Anabolic androgenic steroid abuse in the United Kingdom; an update: the increasing popularity of anabolic androgenic steroids

Carrie Mullen*, Benjamin J. Whalley, Fabrizio Schifano, Julien S. Baker

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

Anabolic androgenic steroids (AASs) are prescribed for medical conditions related to low testosterone. Abuse of AASs has surged as they become increasingly recognised as potent image enhancement drugs. The primary goal of most abusers is to obtain what they consider to be a more attractive outward appearance. Abuse is complex. There are a vast range of AAS substances available, although due to their illicit nature, the true composition of AAS substances is difficult to evaluate. Users follow dosing patterns which incorporate a number of different AASs, in addition to other pharmaceutical substances believed to complement the desired physical effects or manage unwanted effects.

Studies to support the harms of AASs are limited. Animal work and medical case reports suggest potential to cause serious hepatotoxicity, in addition to possible neurotoxicity, nephrotoxicity and damage to the cardiovascular and reproductive systems. As the long term AAS using cohort reach maturity, further controlled experimentation, with larger sample sizes, is required.

Data gathering should be directed towards establishing knowledge related to the most vulnerable AAS users, which is inclusive of females and adolescent boys.
Original languageEnglish
JournalBritish Journal of Pharmacology
Early online date28 Jan 2020
DOIs
Publication statusE-pub ahead of print - 28 Jan 2020

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Testosterone Congeners
Image Enhancement
United Kingdom
Cardiovascular System
Pharmaceutical Preparations
Sample Size
Testosterone

Cite this

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title = "Anabolic androgenic steroid abuse in the United Kingdom; an update: the increasing popularity of anabolic androgenic steroids",
abstract = "Anabolic androgenic steroids (AASs) are prescribed for medical conditions related to low testosterone. Abuse of AASs has surged as they become increasingly recognised as potent image enhancement drugs. The primary goal of most abusers is to obtain what they consider to be a more attractive outward appearance. Abuse is complex. There are a vast range of AAS substances available, although due to their illicit nature, the true composition of AAS substances is difficult to evaluate. Users follow dosing patterns which incorporate a number of different AASs, in addition to other pharmaceutical substances believed to complement the desired physical effects or manage unwanted effects.Studies to support the harms of AASs are limited. Animal work and medical case reports suggest potential to cause serious hepatotoxicity, in addition to possible neurotoxicity, nephrotoxicity and damage to the cardiovascular and reproductive systems. As the long term AAS using cohort reach maturity, further controlled experimentation, with larger sample sizes, is required.Data gathering should be directed towards establishing knowledge related to the most vulnerable AAS users, which is inclusive of females and adolescent boys.",
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Anabolic androgenic steroid abuse in the United Kingdom; an update : the increasing popularity of anabolic androgenic steroids. / Mullen, Carrie; Whalley, Benjamin J.; Schifano, Fabrizio; Baker, Julien S.

In: British Journal of Pharmacology, 28.01.2020.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Anabolic androgenic steroid abuse in the United Kingdom; an update

T2 - the increasing popularity of anabolic androgenic steroids

AU - Mullen, Carrie

AU - Whalley, Benjamin J.

AU - Schifano, Fabrizio

AU - Baker, Julien S.

PY - 2020/1/28

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N2 - Anabolic androgenic steroids (AASs) are prescribed for medical conditions related to low testosterone. Abuse of AASs has surged as they become increasingly recognised as potent image enhancement drugs. The primary goal of most abusers is to obtain what they consider to be a more attractive outward appearance. Abuse is complex. There are a vast range of AAS substances available, although due to their illicit nature, the true composition of AAS substances is difficult to evaluate. Users follow dosing patterns which incorporate a number of different AASs, in addition to other pharmaceutical substances believed to complement the desired physical effects or manage unwanted effects.Studies to support the harms of AASs are limited. Animal work and medical case reports suggest potential to cause serious hepatotoxicity, in addition to possible neurotoxicity, nephrotoxicity and damage to the cardiovascular and reproductive systems. As the long term AAS using cohort reach maturity, further controlled experimentation, with larger sample sizes, is required.Data gathering should be directed towards establishing knowledge related to the most vulnerable AAS users, which is inclusive of females and adolescent boys.

AB - Anabolic androgenic steroids (AASs) are prescribed for medical conditions related to low testosterone. Abuse of AASs has surged as they become increasingly recognised as potent image enhancement drugs. The primary goal of most abusers is to obtain what they consider to be a more attractive outward appearance. Abuse is complex. There are a vast range of AAS substances available, although due to their illicit nature, the true composition of AAS substances is difficult to evaluate. Users follow dosing patterns which incorporate a number of different AASs, in addition to other pharmaceutical substances believed to complement the desired physical effects or manage unwanted effects.Studies to support the harms of AASs are limited. Animal work and medical case reports suggest potential to cause serious hepatotoxicity, in addition to possible neurotoxicity, nephrotoxicity and damage to the cardiovascular and reproductive systems. As the long term AAS using cohort reach maturity, further controlled experimentation, with larger sample sizes, is required.Data gathering should be directed towards establishing knowledge related to the most vulnerable AAS users, which is inclusive of females and adolescent boys.

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SN - 0007-1188

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