Adsorbed on the adsorbed protein layer formed on a laser modified zirconia bioceramic

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The nature of the surface strongly influences the composition and recognisability of the adsorbed protein layer, which in turn affects the subsequent cellular interactions. Thus, to understand the biological response to a material, especially in vitro, one must fully understand the nature of the adsorbed protein film that forms on the material. This study is to investigate the fundamental interactions between the human serum albumin (no-cell adhesive) and human plasma fibronectin and bioinert ceramic following the CO2 laser treatment. The analysis of the albumin and fibronectin adsorption was conducted on the untreated and CO2 laser modified magnesia partially stabilised zirconia (MgO-PSZ) bioceramic using an ellipsometry. It was found that the adsorptions of albumin and fibronectin were influenced by the surface properties. The albumin adsorption was affected by the surface roughness and wettability characteristics of the MgOPSZ and decreased with these properties. While the fibronectin adsorption was increased with wettability characteristic and predominantly governed by this property. Moreover, the considerable change in the polar component of surface energy,γsvp, and its effect on protein adsorption implied that the albumin and fibronectin adsorption on the MgO-PSZ surfaces was probably due to the polar and chemical interactions. The value of this work is to provide a novel technique and useful information for mediating protein adsorption and thereof cellular interactions.
Original languageEnglish
Title of host publicationProceedings of the 23rd International Congress on Laser Materials Processing and Laser Microfabrication
EditorsRajesh Patel
Place of PublicationUnited States
PublisherLaser Institute of America
ISBN (Print)9780912035772
DOIs
Publication statusPublished - 1 Oct 2004
Externally publishedYes
Event23rd International Congress on Laser Materials Processing and Laser Microfabrication - San Francisco, United States
Duration: 4 Oct 20047 Oct 2004
https://lia.scitation.org/toc/ica/2004/1?size=20&windowStart=60

Conference

Conference23rd International Congress on Laser Materials Processing and Laser Microfabrication
Abbreviated titleICALEO 2004
Country/TerritoryUnited States
CitySan Francisco
Period4/10/047/10/04
Internet address

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