Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites

Mostafa Rateb, Dong Yang, Sanja Vodanovic-Jankovic, Zhiguo Yu, Michael A. Kron, Ben Shen

Research output: Contribution to journalComment/debate

6 Citations (Scopus)

Abstract

Lymphatic filariasis (LF), also known as elephantiasis, is one of the World Health Organization’s (WHO’s) top 10 neglected tropical diseases. LF is caused primarily by two related parasites, Brugia malayi and Wuchereria bancrofti, and represents a worldwide health crisis with over 200 million people infected and another 20% of the global population at risk for infection. Aminoacyl-tRNA synthetases (AARSs) were the first filarial targets for antiparasite drug discovery embraced by the WHO and are generally regarded as excellent therapeutic targets because AARSs have a key role in protein synthesis. Among the AARSs, in particular, asparaginyl-tRNA synthetase (AsnRS) in B. malayi is considered an excellent antifilarial target because (i) it is highly expressed in both sexes, adults and larvae of B. malayi
Original languageEnglish
Pages (from-to)540-542
JournalThe Journal of Antibiotics
Volume68
Issue number8
DOIs
Publication statusPublished - 2015
Externally publishedYes

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