Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites

Mostafa Rateb; Dong Yang; Sanja Vodanovic-Jankovic; Zhiguo Yu; Michael A.  Kron; Ben Shen

doi:10.1038/ja.2015.22

Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites

Mostafa Rateb, Dong Yang, Sanja Vodanovic-Jankovic, Zhiguo Yu, Michael A. Kron, Ben Shen

Research output: Contribution to journal › Comment/debate › peer-review

12 Citations (Scopus)

Abstract

Lymphatic filariasis (LF), also known as elephantiasis, is one of the World Health Organization’s (WHO’s) top 10 neglected tropical diseases. LF is caused primarily by two related parasites, Brugia malayi and Wuchereria bancrofti, and represents a worldwide health crisis with over 200 million people infected and another 20% of the global population at risk for infection. Aminoacyl-tRNA synthetases (AARSs) were the first filarial targets for antiparasite drug discovery embraced by the WHO and are generally regarded as excellent therapeutic targets because AARSs have a key role in protein synthesis. Among the AARSs, in particular, asparaginyl-tRNA synthetase (AsnRS) in B. malayi is considered an excellent antifilarial target because (i) it is highly expressed in both sexes, adults and larvae of B. malayi

Original language	English
Pages (from-to)	540-542
Journal	The Journal of Antibiotics
Volume	68
Issue number	8
DOIs	https://doi.org/10.1038/ja.2015.22
Publication status	Published - 2015
Externally published	Yes

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@article{c3b9220924214fab891153ccc9fc8352,

title = "Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites",

abstract = "Lymphatic filariasis (LF), also known as elephantiasis, is one of the World Health Organization{\textquoteright}s (WHO{\textquoteright}s) top 10 neglected tropical diseases. LF is caused primarily by two related parasites, Brugia malayi and Wuchereria bancrofti, and represents a worldwide health crisis with over 200 million people infected and another 20% of the global population at risk for infection. Aminoacyl-tRNA synthetases (AARSs) were the first filarial targets for antiparasite drug discovery embraced by the WHO and are generally regarded as excellent therapeutic targets because AARSs have a key role in protein synthesis. Among the AARSs, in particular, asparaginyl-tRNA synthetase (AsnRS) in B. malayi is considered an excellent antifilarial target because (i) it is highly expressed in both sexes, adults and larvae of B. malayi",

author = "Mostafa Rateb and Dong Yang and Sanja Vodanovic-Jankovic and Zhiguo Yu and Kron, {Michael A.} and Ben Shen",

year = "2015",

doi = "10.1038/ja.2015.22",

language = "English",

volume = "68",

pages = "540--542",

journal = "The Journal of Antibiotics",

issn = "0021-8820",

publisher = "Springer Nature",

number = "8",

}

TY - JOUR

T1 - Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites

AU - Rateb, Mostafa

AU - Yang, Dong

AU - Vodanovic-Jankovic, Sanja

AU - Yu, Zhiguo

AU - Kron, Michael A.

AU - Shen, Ben

PY - 2015

Y1 - 2015

N2 - Lymphatic filariasis (LF), also known as elephantiasis, is one of the World Health Organization’s (WHO’s) top 10 neglected tropical diseases. LF is caused primarily by two related parasites, Brugia malayi and Wuchereria bancrofti, and represents a worldwide health crisis with over 200 million people infected and another 20% of the global population at risk for infection. Aminoacyl-tRNA synthetases (AARSs) were the first filarial targets for antiparasite drug discovery embraced by the WHO and are generally regarded as excellent therapeutic targets because AARSs have a key role in protein synthesis. Among the AARSs, in particular, asparaginyl-tRNA synthetase (AsnRS) in B. malayi is considered an excellent antifilarial target because (i) it is highly expressed in both sexes, adults and larvae of B. malayi

AB - Lymphatic filariasis (LF), also known as elephantiasis, is one of the World Health Organization’s (WHO’s) top 10 neglected tropical diseases. LF is caused primarily by two related parasites, Brugia malayi and Wuchereria bancrofti, and represents a worldwide health crisis with over 200 million people infected and another 20% of the global population at risk for infection. Aminoacyl-tRNA synthetases (AARSs) were the first filarial targets for antiparasite drug discovery embraced by the WHO and are generally regarded as excellent therapeutic targets because AARSs have a key role in protein synthesis. Among the AARSs, in particular, asparaginyl-tRNA synthetase (AsnRS) in B. malayi is considered an excellent antifilarial target because (i) it is highly expressed in both sexes, adults and larvae of B. malayi

U2 - 10.1038/ja.2015.22

DO - 10.1038/ja.2015.22

M3 - Comment/debate

SN - 0021-8820

VL - 68

SP - 540

EP - 542

JO - The Journal of Antibiotics

JF - The Journal of Antibiotics

IS - 8

ER -

Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites

Abstract

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