Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis

Nastaran Majdinasab; Robert W. Motl; Motahare Mokhtarzade; Philipp Zimmer; Rouholah Ranjbar; Charly Keytsman; Tom Cullen; Raoof Negaresh; Julien S. Baker

doi:10.1016/j.ctcp.2018.03.004

Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis

Nastaran Majdinasab, Robert W. Motl, Motahare Mokhtarzade, Philipp Zimmer, Rouholah Ranjbar, Charly Keytsman, Tom Cullen, Raoof Negaresh, Julien S. Baker

School of Health and Life Sciences

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

137 Downloads (Pure)

Abstract

Objective

To examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS).

Methods

Thirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60–70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise.

Results

Levels of IL-10 and TNF-α in response to exercise were similar in healthy and MS remitting subjects. Compared to baseline, TNF-α levels in relapsing subjects were significantly decreased immediately after exercise. Immediately following exercise, leptin levels significantly decreased in relapsing subjects. Adiponectin and IL-6 showed no significant difference between groups.

Conclusion

After relapse, exercise does not induce inflammatory cytokine response and temporarily improves both cytokine and adipokine balance.

Original language	English
Pages (from-to)	295-301
Journal	Complementary Therapies in Clinical Practice
Volume	31
Early online date	14 Mar 2018
DOIs	https://doi.org/10.1016/j.ctcp.2018.03.004
Publication status	Published - 1 May 2018

Access to Document

10.1016/j.ctcp.2018.03.004

Cite this

@article{4fcd8fdced0d4978b8035622919b1552,

title = "Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis",

abstract = "ObjectiveTo examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS).MethodsThirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60–70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise.ResultsLevels of IL-10 and TNF-α in response to exercise were similar in healthy and MS remitting subjects. Compared to baseline, TNF-α levels in relapsing subjects were significantly decreased immediately after exercise. Immediately following exercise, leptin levels significantly decreased in relapsing subjects. Adiponectin and IL-6 showed no significant difference between groups.ConclusionAfter relapse, exercise does not induce inflammatory cytokine response and temporarily improves both cytokine and adipokine balance.",

author = "Nastaran Majdinasab and Motl, {Robert W.} and Motahare Mokhtarzade and Philipp Zimmer and Rouholah Ranjbar and Charly Keytsman and Tom Cullen and Raoof Negaresh and Baker, {Julien S.}",

year = "2018",

month = may,

day = "1",

doi = "10.1016/j.ctcp.2018.03.004",

language = "English",

volume = "31",

pages = "295--301",

journal = "Complementary Therapies in Clinical Practice",

issn = "1744-3881",

publisher = "Churchill Livingstone",

}

TY - JOUR

T1 - Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis

AU - Majdinasab, Nastaran

AU - Motl, Robert W.

AU - Mokhtarzade, Motahare

AU - Zimmer, Philipp

AU - Ranjbar, Rouholah

AU - Keytsman, Charly

AU - Cullen, Tom

AU - Negaresh, Raoof

AU - Baker, Julien S.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - ObjectiveTo examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS).MethodsThirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60–70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise.ResultsLevels of IL-10 and TNF-α in response to exercise were similar in healthy and MS remitting subjects. Compared to baseline, TNF-α levels in relapsing subjects were significantly decreased immediately after exercise. Immediately following exercise, leptin levels significantly decreased in relapsing subjects. Adiponectin and IL-6 showed no significant difference between groups.ConclusionAfter relapse, exercise does not induce inflammatory cytokine response and temporarily improves both cytokine and adipokine balance.

AB - ObjectiveTo examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS).MethodsThirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60–70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise.ResultsLevels of IL-10 and TNF-α in response to exercise were similar in healthy and MS remitting subjects. Compared to baseline, TNF-α levels in relapsing subjects were significantly decreased immediately after exercise. Immediately following exercise, leptin levels significantly decreased in relapsing subjects. Adiponectin and IL-6 showed no significant difference between groups.ConclusionAfter relapse, exercise does not induce inflammatory cytokine response and temporarily improves both cytokine and adipokine balance.

U2 - 10.1016/j.ctcp.2018.03.004

DO - 10.1016/j.ctcp.2018.03.004

M3 - Article

SN - 1744-3881

VL - 31

SP - 295

EP - 301

JO - Complementary Therapies in Clinical Practice

JF - Complementary Therapies in Clinical Practice

ER -

Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis

Abstract

Access to Document

Fingerprint

Cite this