Activity monitoring reflects cardiovascular and metabolic variations in COPD patients across GOLD stages II to IV

E.A. Kortianou, Z. Louvaris, M. Vasilopoulou, I. Nasis, G. Kaltsakas, N.G. Koulouris, I. Vogiatzis

Research output: Contribution to journalArticle

Abstract

We investigated whether activity monitoring reliably reflects variations in oxygen transport and utilization during walking in COPD patients. Forty-two patients (14 in each GOLD stage 11,111 and IV) performed an incremental treadmill protocol to the limit of tolerance. Breath-by-breath gas exchange, central hemodynamic variables and activity monitoring were simultaneously recorded. Physiological variables and accelerometer outputs rose linearly with walking speeds. Strong correlations (r[interquartile range, IQR]) were found between treadmill walking intensity (WI: range 0.8-2.0 m s(-2)) and oxygen consumption (0.95 [IQR 0.87-0.97]), (range 7.6-15.5 ml kg(-1) min(-1)); minute ventilation (0.95 [IQR 0.86-0.98]), (range 20-37l min(-1)); cardiac output (0.89 [IQR 0.73-0.94]), (range 6.8-11.5l min(-1)) and arteriovenous oxygen concentration difference (0.84 [IQR 0.76-0.90]), (range 7.7-12.1 ml O-2 100 ml(-1)). Correlations between WI and gas exchange or central hemodynamic parameters were not different across GOLD stages. In conclusion, central hemodynamic, respiratory and muscle metabolic variations during incremental treadmill exercise are tightly associated to changes in walking intensity as recorded by accelerometry across GOLD stages II to IV. Interestingly, the magnitude of these associations is not different across GOLD stages.
Original languageEnglish
Pages (from-to)513-520
Number of pages8
JournalRespiratory Physiology & Neurobiology
Volume189
Issue number3
DOIs
Publication statusPublished - 1 Dec 2013

Keywords

  • COPD
  • Activity monitoring
  • Cardiac output
  • Indirect calorimetry
  • Walking
  • Physical activity

Cite this

Kortianou, E.A. ; Louvaris, Z. ; Vasilopoulou, M. ; Nasis, I. ; Kaltsakas, G. ; Koulouris, N.G. ; Vogiatzis, I. / Activity monitoring reflects cardiovascular and metabolic variations in COPD patients across GOLD stages II to IV. In: Respiratory Physiology & Neurobiology. 2013 ; Vol. 189, No. 3. pp. 513-520.
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abstract = "We investigated whether activity monitoring reliably reflects variations in oxygen transport and utilization during walking in COPD patients. Forty-two patients (14 in each GOLD stage 11,111 and IV) performed an incremental treadmill protocol to the limit of tolerance. Breath-by-breath gas exchange, central hemodynamic variables and activity monitoring were simultaneously recorded. Physiological variables and accelerometer outputs rose linearly with walking speeds. Strong correlations (r[interquartile range, IQR]) were found between treadmill walking intensity (WI: range 0.8-2.0 m s(-2)) and oxygen consumption (0.95 [IQR 0.87-0.97]), (range 7.6-15.5 ml kg(-1) min(-1)); minute ventilation (0.95 [IQR 0.86-0.98]), (range 20-37l min(-1)); cardiac output (0.89 [IQR 0.73-0.94]), (range 6.8-11.5l min(-1)) and arteriovenous oxygen concentration difference (0.84 [IQR 0.76-0.90]), (range 7.7-12.1 ml O-2 100 ml(-1)). Correlations between WI and gas exchange or central hemodynamic parameters were not different across GOLD stages. In conclusion, central hemodynamic, respiratory and muscle metabolic variations during incremental treadmill exercise are tightly associated to changes in walking intensity as recorded by accelerometry across GOLD stages II to IV. Interestingly, the magnitude of these associations is not different across GOLD stages.",
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Activity monitoring reflects cardiovascular and metabolic variations in COPD patients across GOLD stages II to IV. / Kortianou, E.A.; Louvaris, Z.; Vasilopoulou, M.; Nasis, I.; Kaltsakas, G.; Koulouris, N.G.; Vogiatzis, I.

In: Respiratory Physiology & Neurobiology, Vol. 189, No. 3, 01.12.2013, p. 513-520.

Research output: Contribution to journalArticle

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AU - Kortianou, E.A.

AU - Louvaris, Z.

AU - Vasilopoulou, M.

AU - Nasis, I.

AU - Kaltsakas, G.

AU - Koulouris, N.G.

AU - Vogiatzis, I.

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N2 - We investigated whether activity monitoring reliably reflects variations in oxygen transport and utilization during walking in COPD patients. Forty-two patients (14 in each GOLD stage 11,111 and IV) performed an incremental treadmill protocol to the limit of tolerance. Breath-by-breath gas exchange, central hemodynamic variables and activity monitoring were simultaneously recorded. Physiological variables and accelerometer outputs rose linearly with walking speeds. Strong correlations (r[interquartile range, IQR]) were found between treadmill walking intensity (WI: range 0.8-2.0 m s(-2)) and oxygen consumption (0.95 [IQR 0.87-0.97]), (range 7.6-15.5 ml kg(-1) min(-1)); minute ventilation (0.95 [IQR 0.86-0.98]), (range 20-37l min(-1)); cardiac output (0.89 [IQR 0.73-0.94]), (range 6.8-11.5l min(-1)) and arteriovenous oxygen concentration difference (0.84 [IQR 0.76-0.90]), (range 7.7-12.1 ml O-2 100 ml(-1)). Correlations between WI and gas exchange or central hemodynamic parameters were not different across GOLD stages. In conclusion, central hemodynamic, respiratory and muscle metabolic variations during incremental treadmill exercise are tightly associated to changes in walking intensity as recorded by accelerometry across GOLD stages II to IV. Interestingly, the magnitude of these associations is not different across GOLD stages.

AB - We investigated whether activity monitoring reliably reflects variations in oxygen transport and utilization during walking in COPD patients. Forty-two patients (14 in each GOLD stage 11,111 and IV) performed an incremental treadmill protocol to the limit of tolerance. Breath-by-breath gas exchange, central hemodynamic variables and activity monitoring were simultaneously recorded. Physiological variables and accelerometer outputs rose linearly with walking speeds. Strong correlations (r[interquartile range, IQR]) were found between treadmill walking intensity (WI: range 0.8-2.0 m s(-2)) and oxygen consumption (0.95 [IQR 0.87-0.97]), (range 7.6-15.5 ml kg(-1) min(-1)); minute ventilation (0.95 [IQR 0.86-0.98]), (range 20-37l min(-1)); cardiac output (0.89 [IQR 0.73-0.94]), (range 6.8-11.5l min(-1)) and arteriovenous oxygen concentration difference (0.84 [IQR 0.76-0.90]), (range 7.7-12.1 ml O-2 100 ml(-1)). Correlations between WI and gas exchange or central hemodynamic parameters were not different across GOLD stages. In conclusion, central hemodynamic, respiratory and muscle metabolic variations during incremental treadmill exercise are tightly associated to changes in walking intensity as recorded by accelerometry across GOLD stages II to IV. Interestingly, the magnitude of these associations is not different across GOLD stages.

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KW - Activity monitoring

KW - Cardiac output

KW - Indirect calorimetry

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JF - Respiratory Physiology & Neurobiology

SN - 1569-9048

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ER -