Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake

Ruth  McClelland; Kelly  Christensen; Suhaib  Mohammed; Dagmara  McGuinness; Josephine  Cooney; Andisheh Bakhshi; Evangelia  Demou; Ewan  MacDonald; Muriel  Caslake; Peter  Stenvinkel; Paul  Shiels

doi:10.18632/aging.100948

Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake

Ruth McClelland
, Kelly Christensen
, Suhaib Mohammed
, Dagmara McGuinness
, Josephine Cooney
, Andisheh Bakhshi
, Evangelia Demou
, Ewan MacDonald
, Muriel Caslake
, Peter Stenvinkel
, Paul Shiels

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Background
We have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated ageing in rodent models of progeria we tested whether variation in Pi levels in man associate with measures of biological ageing and health.

Results
We observed significant relationships between serum Pi levels and markers of biological age (telomere length (p=0.040) and DNA methylation content (p=0.028), gender and chronological age (p=0.032). When analyses were adjusted for socio-economic status and nutritional factors, associations were observed between accelerated biological ageing (telomere length, genomic methylation content) and dietary derived Pi levels among the most deprived males, directly related to the frequency of red meat consumption.

Conclusions
Accelerated ageing is associated with high serum Pi levels and frequency of red meat consumption. Our data provide evidence for a mechanistic link between high intake of Pi and age-related morbidities tied to socio-economic status.
Keywords: phosphate, diet, poverty, ageing, CKD, pSoBid

Original language	English
Pages (from-to)	1135—1149
Journal	Aging
Volume	8
Issue number	5
DOIs	https://doi.org/10.18632/aging.100948
Publication status	Published - 26 Apr 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

phosphate
diet
poverty
ageing
CKD
pSoBid

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Cite this

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title = "Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake",

abstract = "Background We have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated ageing in rodent models of progeria we tested whether variation in Pi levels in man associate with measures of biological ageing and health. Results We observed significant relationships between serum Pi levels and markers of biological age (telomere length (p=0.040) and DNA methylation content (p=0.028), gender and chronological age (p=0.032). When analyses were adjusted for socio-economic status and nutritional factors, associations were observed between accelerated biological ageing (telomere length, genomic methylation content) and dietary derived Pi levels among the most deprived males, directly related to the frequency of red meat consumption. Conclusions Accelerated ageing is associated with high serum Pi levels and frequency of red meat consumption. Our data provide evidence for a mechanistic link between high intake of Pi and age-related morbidities tied to socio-economic status. Keywords: phosphate, diet, poverty, ageing, CKD, pSoBid",

keywords = "phosphate, diet, poverty, ageing, CKD, pSoBid",

author = "Ruth McClelland and Kelly Christensen and Suhaib Mohammed and Dagmara McGuinness and Josephine Cooney and Andisheh Bakhshi and Evangelia Demou and Ewan MacDonald and Muriel Caslake and Peter Stenvinkel and Paul Shiels",

year = "2016",

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doi = "10.18632/aging.100948",

language = "English",

volume = "8",

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journal = "Aging",

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T1 - Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake

AU - McClelland, Ruth

AU - Christensen, Kelly

AU - Mohammed, Suhaib

AU - McGuinness, Dagmara

AU - Cooney, Josephine

AU - Bakhshi, Andisheh

AU - Demou, Evangelia

AU - MacDonald, Ewan

AU - Caslake, Muriel

AU - Stenvinkel, Peter

AU - Shiels, Paul

PY - 2016/4/26

Y1 - 2016/4/26

N2 - Background We have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated ageing in rodent models of progeria we tested whether variation in Pi levels in man associate with measures of biological ageing and health. Results We observed significant relationships between serum Pi levels and markers of biological age (telomere length (p=0.040) and DNA methylation content (p=0.028), gender and chronological age (p=0.032). When analyses were adjusted for socio-economic status and nutritional factors, associations were observed between accelerated biological ageing (telomere length, genomic methylation content) and dietary derived Pi levels among the most deprived males, directly related to the frequency of red meat consumption. Conclusions Accelerated ageing is associated with high serum Pi levels and frequency of red meat consumption. Our data provide evidence for a mechanistic link between high intake of Pi and age-related morbidities tied to socio-economic status. Keywords: phosphate, diet, poverty, ageing, CKD, pSoBid

AB - Background We have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated ageing in rodent models of progeria we tested whether variation in Pi levels in man associate with measures of biological ageing and health. Results We observed significant relationships between serum Pi levels and markers of biological age (telomere length (p=0.040) and DNA methylation content (p=0.028), gender and chronological age (p=0.032). When analyses were adjusted for socio-economic status and nutritional factors, associations were observed between accelerated biological ageing (telomere length, genomic methylation content) and dietary derived Pi levels among the most deprived males, directly related to the frequency of red meat consumption. Conclusions Accelerated ageing is associated with high serum Pi levels and frequency of red meat consumption. Our data provide evidence for a mechanistic link between high intake of Pi and age-related morbidities tied to socio-economic status. Keywords: phosphate, diet, poverty, ageing, CKD, pSoBid

KW - phosphate

KW - diet

KW - poverty

KW - ageing

KW - CKD

KW - pSoBid

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U2 - 10.18632/aging.100948

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SP - 1135—1149

JO - Aging

JF - Aging

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ER -

Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake

Abstract

UN SDGs

Keywords

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