Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake

Ruth McClelland, Kelly Christensen, Suhaib Mohammed, Dagmara McGuinness, Josephine Cooney, Andisheh Bakhshi, Evangelia Demou, Ewan MacDonald, Muriel Caslake, Peter Stenvinkel, Paul Shiels

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


We have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated ageing in rodent models of progeria we tested whether variation in Pi levels in man associate with measures of biological ageing and health.

We observed significant relationships between serum Pi levels and markers of biological age (telomere length (p=0.040) and DNA methylation content (p=0.028), gender and chronological age (p=0.032). When analyses were adjusted for socio-economic status and nutritional factors, associations were observed between accelerated biological ageing (telomere length, genomic methylation content) and dietary derived Pi levels among the most deprived males, directly related to the frequency of red meat consumption.

Accelerated ageing is associated with high serum Pi levels and frequency of red meat consumption. Our data provide evidence for a mechanistic link between high intake of Pi and age-related morbidities tied to socio-economic status.
Keywords: phosphate, diet, poverty, ageing, CKD, pSoBid
Original languageEnglish
Pages (from-to)1135—1149
Issue number5
Publication statusPublished - 26 Apr 2016
Externally publishedYes


  • phosphate
  • diet
  • poverty
  • ageing
  • CKD
  • pSoBid


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