Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake

Ruth McClelland, Kelly Christensen, Suhaib Mohammed, Dagmara McGuinness, Josephine Cooney, Andisheh Bakhshi, Evangelia Demou, Ewan MacDonald, Muriel Caslake, Peter Stenvinkel, Paul Shiels

Research output: Contribution to journalArticle

Abstract

Background
We have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated ageing in rodent models of progeria we tested whether variation in Pi levels in man associate with measures of biological ageing and health.

Results
We observed significant relationships between serum Pi levels and markers of biological age (telomere length (p=0.040) and DNA methylation content (p=0.028), gender and chronological age (p=0.032). When analyses were adjusted for socio-economic status and nutritional factors, associations were observed between accelerated biological ageing (telomere length, genomic methylation content) and dietary derived Pi levels among the most deprived males, directly related to the frequency of red meat consumption.

Conclusions
Accelerated ageing is associated with high serum Pi levels and frequency of red meat consumption. Our data provide evidence for a mechanistic link between high intake of Pi and age-related morbidities tied to socio-economic status.
Keywords: phosphate, diet, poverty, ageing, CKD, pSoBid
Original languageEnglish
Pages (from-to)1135—1149
JournalAging
Volume8
Issue number5
DOIs
Publication statusPublished - 26 Apr 2016
Externally publishedYes

Fingerprint

Telomere
Social Class
Phosphates
Progeria
Economics
Kidney
Health
DNA Methylation
Poverty
Nutritional Status
Serum
Methylation
Health Status
Rodentia
Biomarkers
Diet
Morbidity
Red Meat

Keywords

  • phosphate
  • diet
  • poverty
  • ageing
  • CKD
  • pSoBid

Cite this

McClelland, R., Christensen, K., Mohammed, S., McGuinness, D., Cooney, J., Bakhshi, A., ... Shiels, P. (2016). Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake. Aging, 8(5), 1135—1149. https://doi.org/10.18632/aging.100948
McClelland, Ruth ; Christensen, Kelly ; Mohammed, Suhaib ; McGuinness, Dagmara ; Cooney, Josephine ; Bakhshi, Andisheh ; Demou, Evangelia ; MacDonald, Ewan ; Caslake, Muriel ; Stenvinkel, Peter ; Shiels, Paul . / Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake. In: Aging. 2016 ; Vol. 8, No. 5. pp. 1135—1149.
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abstract = "BackgroundWe have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated ageing in rodent models of progeria we tested whether variation in Pi levels in man associate with measures of biological ageing and health.ResultsWe observed significant relationships between serum Pi levels and markers of biological age (telomere length (p=0.040) and DNA methylation content (p=0.028), gender and chronological age (p=0.032). When analyses were adjusted for socio-economic status and nutritional factors, associations were observed between accelerated biological ageing (telomere length, genomic methylation content) and dietary derived Pi levels among the most deprived males, directly related to the frequency of red meat consumption.ConclusionsAccelerated ageing is associated with high serum Pi levels and frequency of red meat consumption. Our data provide evidence for a mechanistic link between high intake of Pi and age-related morbidities tied to socio-economic status.Keywords: phosphate, diet, poverty, ageing, CKD, pSoBid",
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McClelland, R, Christensen, K, Mohammed, S, McGuinness, D, Cooney, J, Bakhshi, A, Demou, E, MacDonald, E, Caslake, M, Stenvinkel, P & Shiels, P 2016, 'Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake' Aging, vol. 8, no. 5, pp. 1135—1149. https://doi.org/10.18632/aging.100948

Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake. / McClelland, Ruth ; Christensen, Kelly ; Mohammed, Suhaib ; McGuinness, Dagmara ; Cooney, Josephine ; Bakhshi, Andisheh; Demou, Evangelia ; MacDonald, Ewan ; Caslake, Muriel ; Stenvinkel, Peter ; Shiels, Paul .

In: Aging, Vol. 8, No. 5, 26.04.2016, p. 1135—1149.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake

AU - McClelland, Ruth

AU - Christensen, Kelly

AU - Mohammed, Suhaib

AU - McGuinness, Dagmara

AU - Cooney, Josephine

AU - Bakhshi, Andisheh

AU - Demou, Evangelia

AU - MacDonald, Ewan

AU - Caslake, Muriel

AU - Stenvinkel, Peter

AU - Shiels, Paul

PY - 2016/4/26

Y1 - 2016/4/26

N2 - BackgroundWe have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated ageing in rodent models of progeria we tested whether variation in Pi levels in man associate with measures of biological ageing and health.ResultsWe observed significant relationships between serum Pi levels and markers of biological age (telomere length (p=0.040) and DNA methylation content (p=0.028), gender and chronological age (p=0.032). When analyses were adjusted for socio-economic status and nutritional factors, associations were observed between accelerated biological ageing (telomere length, genomic methylation content) and dietary derived Pi levels among the most deprived males, directly related to the frequency of red meat consumption.ConclusionsAccelerated ageing is associated with high serum Pi levels and frequency of red meat consumption. Our data provide evidence for a mechanistic link between high intake of Pi and age-related morbidities tied to socio-economic status.Keywords: phosphate, diet, poverty, ageing, CKD, pSoBid

AB - BackgroundWe have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated ageing in rodent models of progeria we tested whether variation in Pi levels in man associate with measures of biological ageing and health.ResultsWe observed significant relationships between serum Pi levels and markers of biological age (telomere length (p=0.040) and DNA methylation content (p=0.028), gender and chronological age (p=0.032). When analyses were adjusted for socio-economic status and nutritional factors, associations were observed between accelerated biological ageing (telomere length, genomic methylation content) and dietary derived Pi levels among the most deprived males, directly related to the frequency of red meat consumption.ConclusionsAccelerated ageing is associated with high serum Pi levels and frequency of red meat consumption. Our data provide evidence for a mechanistic link between high intake of Pi and age-related morbidities tied to socio-economic status.Keywords: phosphate, diet, poverty, ageing, CKD, pSoBid

KW - phosphate

KW - diet

KW - poverty

KW - ageing

KW - CKD

KW - pSoBid

U2 - 10.18632/aging.100948

DO - 10.18632/aging.100948

M3 - Article

VL - 8

SP - 1135—1149

JO - Aging

JF - Aging

SN - 0272-3808

IS - 5

ER -

McClelland R, Christensen K, Mohammed S, McGuinness D, Cooney J, Bakhshi A et al. Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake. Aging. 2016 Apr 26;8(5):1135—1149. https://doi.org/10.18632/aging.100948