A rare case of mixed infectious keratitis caused by Pseudomonas koreensis and Aspergillus fumigatus

L.W. Khoo, S.S. Srinivasan *, F.L. Henriquez, A.M. Bal

*Corresponding author for this work

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We report the clinical and microbiological features of contact lens-related mixed infectious keratitis caused by a spore-forming filamentous fungus and a rare gram-negative bacterial infection. A 66-year-old Caucasian female presented with right eye (OD) pain after sleeping in her 2-weekly contact lenses for 3 days. On presentation, corrected distance visual acuity was 0.46 LogMAR OD and 0.20 in the left eye. Slit lamp biomicroscopy revealed a 1.9 mm by 1.9 mm area of dense stromal infiltrate with epithelial defect. Corneal scrapes grew Aspergillus fumigatus and Pseudomonas koreensis, and culture-directed microbial therapy with oral and topical voriconazole and topical fortified gentamicin along with regular debridement resulted in slow resolution of the infection, leaving a dense stromal scar in the visual axis requiring penetrating keratoplasty. Mixed infectious keratitis caused by filamentous fungi and gram-negative bacteria is rare. Pseudomonas koreensis infection has not been previously reported as a cause of infectious keratitis in humans. In our experience, these mixed infections require prolonged systemic and topical therapy and the secondary scarring may require surgical intervention for vision rehabilitation.
Original languageEnglish
Pages (from-to)600-605
Number of pages6
JournalCase Reports in Ophthalmology
Publication statusPublished - 9 Nov 2020


  • mixed infectious keratitis
  • infectious keratitis
  • gram-negative bacteria
  • bacteria
  • fungus


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