A multichannel model-based methodology for extubation readiness decision of patients on weaning trials

Pablo Casaseca-de-la-Higuera, Federico Simmross-Wattenberg, Marcos Martin-Fernandez, Carlos Alberola-Lopez

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Discontinuation of mechanical ventilation is a challenging task that involves a number of subtle clinical issues. The gradual removal of the respiratory support (referred to as weaning) should be performed as soon as autonomous respiration can be sustained. However, the prediction rate of successful extubation is still below 25% based on previous studies. Construction of an automatic system that provides information on extubation readiness is thus desirable. Recent works have demonstrated that the breathing pattern variability is a useful extubation readiness indicator, with improving performance when multiple respiratory signals are jointly processed. However, the existing methods for predictor extraction present several drawbacks when length-limited time series are to be processed in heterogeneous groups of patients. In this paper, we propose a model-based methodology for automatic readiness prediction. It is intended to deal with multichannel, nonstationary, short records of the breathing pattern. Results on experimental data yield an 87.27% of successful readiness prediction, which is in line with the best figures reported in the literature. A comparative analysis shows that our methodology overcomes the shortcomings of so far proposed methods when applied to length-limited records on heterogeneous groups of patients.
Original languageEnglish
Pages (from-to)1849-1863
Number of pages15
JournalIEEE Transactions on Biomedical Engineering
Issue number7
Publication statusPublished - Jul 2009
Externally publishedYes


  • Kullback-Leibler divergence
  • multichannel signal processing
  • stochastic volatility models
  • weaning outcome assessment


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