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  • John Lockhart
2020

Exosomes in intercellular communication and implications for osteoarthritis

Asghar, S., Litherland, G. J., Lockhart, J. C., Goodyear, C. S. & Crilly, A., 1 Jan 2020, In : Rheumatology. 59, 1, p. 57-68 12 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)
2019

Accelerated post traumatic osteoarthritis in a dual injury murine model

McCulloch, K., Huesa, C., Dunning, L., Litherland, G. J., Van't Hof, R. J., Lockhart, J. C. & Goodyear, C. S., 31 Dec 2019, In : Osteoarthritis and Cartilage. 27, 12, p. 1800-1810 11 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
117 Downloads (Pure)

Differential effects of exosomes derived from separate osteoarthritis synovial compartments: implications for erosive cartilage disease

Asghar, S., Litherland, G., Meek, D., Cole, J., Lockhart, J., Goodyear, C. S. & Crilly, A., 30 Apr 2019, In : Osteoarthritis and Cartilage. 27, S1, p. S192 1 p., 260.

Research output: Contribution to journalMeeting Abstract

1 Citation (Scopus)

Enhanced airway smooth muscle relaxation via proteinase activated receptor 2

Black, K., MacKenzie, A., Dunning, L., Crilly, A., Brzeszczynska, J., McGarvey, L., Thornbury, K., Goodyear, C. S., Lockhart, J. C. & Litherland, G. J., 22 Nov 2019, In : Irish Journal of Medical Science. 188, SUPPL 10, p. 286-286 1 p.

Research output: Contribution to journalMeeting Abstract

Evaluation of novel serine protease inhibitors to ameliorate cockroach-induced airway inflammation and cell damage

Reihill, J., Yang, Z., Carroll, E., McGarvey, L., Lundy, F., Lockhart, J., Sergeant, G. & Martin, L., 6 Apr 2019.

Research output: Contribution to conferenceAbstract

Inhibition of ENaC activity by novel peptide trypsin-like inhibitors derived from amphibian skin secretions

Carroll, E., Chen, T., Douglas, L., Hollywood, M., Lockhart, J., Martin, S. L., Lundy, F., McGarvey, L., Reihill, J. & Zhou, M., 6 Apr 2019.

Research output: Contribution to conferenceAbstract

PAR2 accelerates osteoarthritis-like joint changes in a murine model of post-traumatic osteoarthritis

Goodyear, C., McCulloch, K., Huesa, C., Dunning, L., van 't Hof, R. & Lockhart, J., 27 Jun 2019, In : Annals of the Rheumatic Diseases. 78, Issue Suppl 2, p. 110-110 1 p.

Research output: Contribution to journalMeeting Abstract

Open Access

Proteinase activated receptor 2 (PAR2) modulation of murine airway function

Black, K., MacKenzie, A., Dunning, L., Crilly, A., Brzeszczyńska, J., McGarvey, L., Thornbury, K., Goodyear, C. S., Lockhart, J. & Litherland, G., 10 Sep 2019.

Research output: Contribution to conferencePoster

Open Access
File
2 Downloads (Pure)

Proteinase activated receptor 2 modulates expression of autophagy markers in murine lungs

McCallum, K., Dunning, L., McGarvey, L., Hollywood, M., Goodyear, C. S., Brzeszczynska, J., Crilly, A., Lockhart, J. C. & Litherland, G. J., 22 Nov 2019, In : Irish Journal of Medical Science. 188, SUPPL 10, p. S270-S270 1 p., 2.6.

Research output: Contribution to journalMeeting Abstract

Understanding PAR2 matriptase ENaC crosstalk in the lung: implications for COPD

Bailo, M., Dunning, L., Brzeszczynska, J., Martin, S. L., Sergeant, G. P., Goodyear, C. S., Litherland, G. J., Lockhart, J. C. & Crilly, A., 30 Nov 2019, In : Irish Journal of Medical Science. 188, SUPPL 10, p. 268-269 2 p.

Research output: Contribution to journalMeeting Abstract

2018

Accelerated osteoarthritic-like symptoms in a novel dual injury model combining destabilisation of the medial meniscus and cartilage damage

McCulloch, K., Huesa, C., Dunning, L., van't Hof, R., Lockhart, J. & Goodyear, C., 28 Sep 2018.

Research output: Contribution to conferenceAbstract

A combined model of destabilisation of the medial meniscus and cartilage damage accelerates osteophytogenesis in osteoarthritis

McCulloch, K., Huesa, C., Dunning, L., van 't Hof, R., Lockhart, J. & Goodyear, C., 26 Apr 2018, p. 32-32. 1 p.

Research output: Contribution to conferencePoster

A novel dual injury osteoarthritis (OA) model that combines destabilisation of the medial meniscus and cartilage damage leads to accelerated osteophytogenesis

McCulloch, K., Huesa, C., Dunning, L., van't Hof, R., Lockhart, J. & Goodyear, C. S., 23 Feb 2018. 1 p.

Research output: Contribution to conferencePoster

Assessment of the effects of exercise on a murine model of OA

Huesa, C., Dunning, L., Macdougall, K., Ortiz, A., Villaluz, M. M., Fegen, M., Crilly, A., Litherland, G., MacKenzie, A., van't Hof, R., Goodyear, C. & Lockhart, J., 30 Apr 2018, In : Osteoarthritis and Cartilage. 26, Supplement 1, p. s68 1 p.

Research output: Contribution to journalMeeting Abstract

Inhibition of ENaC activity by novel peptide trypsin-like inhibitors derived from amphibian skin secretions

Carroll, E. L., Douglas, L. E. J., Reihill, J. A., Zhou, M., Chen, T., McGarvey, L. P., Lundy, F. T., Hollywood, M. A., Crilly, A., Lockhart, J. C. & Martin, S. L., Aug 2018, In : Irish Journal of Medical Science. 187, Supplement 8, p. S250-S251 2 p.

Research output: Contribution to journalMeeting Abstract

Isolation and characterisation of exosomes from human primary bronchial epithelial cells

Lockhart, J., Downey, N., McGarvey, L., Martin, L., Crilly, A., Reihill, J. & Lundy, F., 2018, In : Irish Journal of Medical Science. 187, Supplement 8, p. S252-S252 1 p.

Research output: Contribution to journalMeeting Abstract

Protease activated receptor 2 (PAR2) expression in the myeloid compartment impacts osteoclastogenesis

Lockhart, J., McGrath, S., Hultin, L. & Goodyear, C., 21 Feb 2018, In : Annals of the Rheumatic Diseases. 77, Supplement 1, p. A21 1 p., P018.

Research output: Contribution to journalMeeting Abstract

35 Citations (Scopus)

Proteinase activated receptor 2 (PAR2) modulation of airway smooth muscle function

Black, K., MacKenzie, A., Dunning, L., Crilly, A., McGarvey, L., Thornbury, K., Goodyear, C., Lockhart, J. & Litherland, G., 8 Oct 2018, In : Irish Journal of Medical Science. 187, Supplement 8, p. S249-S249 1 p.

Research output: Contribution to journalMeeting Abstract

Open Access
File
14 Downloads (Pure)

Rheumatic disease: protease-activated receptor-2 in synovial joint pathobiology

McCulloch, K., McGrath, S., Huesa, C., Dunning, L., Litherland, G., Crilly, A., Hultin, L., Ferrell, W. R., Lockhart, J. & Goodyear, C., 23 May 2018, In : Frontiers in Endocrinology. 9, 257.

Research output: Contribution to journalReview article

Open Access
1 Citation (Scopus)

The synovial secretome contributes to cartilage pathology in osteoarthritis: a role for exosomes

Asghar, S., Litherland, G., Meek, D., Goodyear, C., Lockhart, J. & Crilly, A., 30 Apr 2018, In : Osteoarthritis and Cartilage. 26, Supplement 1, p. s131-s132 2 p., 248.

Research output: Contribution to journalMeeting Abstract

2017
Open Access
File
2 Citations (Scopus)
111 Downloads (Pure)

The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover

Wilkinson, D. J., Desilets, A., Lin, H., Charlton, S., del Carmen Arques, M., Falconer, A., Bullock, C., Hsu, Y-C., Birchall, K., Hawkins, A., Thompson, P., Ferrell, W. R., Lockhart, J., Plevin, R., Zhang, Y., Blain, E., Lin, S-W., Leduc, R., Milner, J. M. & Rowan, A. D., 1 Dec 2017, In : Scientific Reports. 7, p. 1-38 38 p., 16693.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
107 Downloads (Pure)

The synovial secretome contributes to cartilage pathology in osteoarthritis (OA): an Exosome Study

Asghar, S., Litherland, G., Meek, D., Goodyear, C., Lockhart, J. & Crilly, A., 5 Dec 2017, (Accepted/In press).

Research output: Contribution to conferencePoster

2016

Evaluating the impact of protease activated receptor 2 (PAR2) gene disruption on T regulatory cell biology

Crilly, A., Cochrane, D., Plevin, R., Ferrell, W. R., McInness, I. B., Goodyear, C. & Lockhart, J., 8 Dec 2016.

Research output: Contribution to conferencePoster

Open Access

Proteinase-activated Receptor 2: Potential Role in Osteoarthritic Entheseal Pathology

Ortiz, A., Dunning, L., Huesa, C., Ferrell, W. R., McInnes, I. B., Lockhart, J., Millar, N. L., Goodyear, C. S. & Crilly, A., 27 Oct 2016, In : Orthopaedic Proceedings. 98-B, Suppl. 16

Research output: Contribution to journalMeeting Abstract

Open Access

Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology

Huesa, C., Ortiz, A. C., Dunning, L., McGavin, L., Bennett, L., McIntosh, K., Crilly, A., Kurowska-Stolarska, M., Plevin, R., van 't Hof, R. J., Rowan, A. D., McInnes, I. B., Goodyear, C. S., Lockhart, J. C. & Ferrell, W. R., 11 Oct 2016, In : Annals of the Rheumatic Diseases. 75, 11, p. 1989-1997

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)