3D patterning/manipulating microparticles and yeast cells using ZnO/Si thin film surface acoustic waves

Xiang Tao, Tan Dai Nguyen, Hao Jin, Ran Tao, Jingting Luo, Xin Yang, Hamdi Torun, Jian Zhou, Shuyi Huang, Lin Shi, Desmond Gibson, Michael Cooke, Hejun Du, Shurong Dong, Jikui Luo, YongQing Fu

Research output: Contribution to journalArticle

Abstract

Manipulating biological cells or microparticles in three dimensions (3D) is invaluable for many biomedical applications, and recently effective and rapid manipulations of microparticles in 2D and 3D within microchannels or chambers using surface acoustic waves (SAWs) with bulk piezoelectric materials have been reported. However, these are generally expensive, or brittle and cannot be easily integrated into a single lab-on-chip. In this paper, we realized microparticle/cell patterning and 3D manipulation of yeast cells inside a chamber with a height of 1 mm using thin film ZnO/Si SAW devices. Effects of SAW frequency, channel width and thickness on alignment of microparticles were firstly investigated, and positions of the microparticles in the direction of SAW propagation can be controlled precisely by changing the phase angle of the acoustic waves from the ZnO/Si SAW device. A numerical model has been developed to investigate the SAW acoustic field and the resulted 3D motions of microparticles under the acoustic radiation forces within the microchamber. Finally, we realized and observed the 3D patterning of yeast cells within the microchannel. Our work shows a great potential for acoustofluidic, neural network research and biomedical applications using the ZnO/Si SAW devices.
Original languageEnglish
Article number126991
Number of pages9
JournalSensors and Actuators B: Chemical
Volume299
Early online date17 Aug 2019
DOIs
Publication statusE-pub ahead of print - 17 Aug 2019

Fingerprint

yeast
microparticles
Acoustic surface wave devices
Yeast
Surface waves
Cells
Acoustic waves
Thin films
surface acoustic wave devices
acoustics
thin films
Microchannels
Acoustic wave propagation
microchannels
Piezoelectric materials
manipulators
Acoustic fields
chambers
Numerical models
Acoustics

Keywords

  • Acoustofluidic
  • ZnO
  • 3D manipulation
  • Yeast cell
  • Lab on a chip

Cite this

Tao, Xiang ; Nguyen, Tan Dai ; Jin, Hao ; Tao, Ran ; Luo, Jingting ; Yang, Xin ; Torun, Hamdi ; Zhou, Jian ; Huang, Shuyi ; Shi, Lin ; Gibson, Desmond ; Cooke, Michael ; Du, Hejun ; Dong, Shurong ; Luo, Jikui ; Fu, YongQing. / 3D patterning/manipulating microparticles and yeast cells using ZnO/Si thin film surface acoustic waves. In: Sensors and Actuators B: Chemical. 2019 ; Vol. 299.
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author = "Xiang Tao and Nguyen, {Tan Dai} and Hao Jin and Ran Tao and Jingting Luo and Xin Yang and Hamdi Torun and Jian Zhou and Shuyi Huang and Lin Shi and Desmond Gibson and Michael Cooke and Hejun Du and Shurong Dong and Jikui Luo and YongQing Fu",
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Tao, X, Nguyen, TD, Jin, H, Tao, R, Luo, J, Yang, X, Torun, H, Zhou, J, Huang, S, Shi, L, Gibson, D, Cooke, M, Du, H, Dong, S, Luo, J & Fu, Y 2019, '3D patterning/manipulating microparticles and yeast cells using ZnO/Si thin film surface acoustic waves', Sensors and Actuators B: Chemical, vol. 299, 126991. https://doi.org/10.1016/j.snb.2019.126991

3D patterning/manipulating microparticles and yeast cells using ZnO/Si thin film surface acoustic waves. / Tao, Xiang; Nguyen, Tan Dai; Jin, Hao; Tao, Ran; Luo, Jingting; Yang, Xin; Torun, Hamdi; Zhou, Jian; Huang, Shuyi; Shi, Lin; Gibson, Desmond; Cooke, Michael; Du, Hejun; Dong, Shurong; Luo, Jikui; Fu, YongQing.

In: Sensors and Actuators B: Chemical, Vol. 299, 126991, 15.11.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - 3D patterning/manipulating microparticles and yeast cells using ZnO/Si thin film surface acoustic waves

AU - Tao, Xiang

AU - Nguyen, Tan Dai

AU - Jin, Hao

AU - Tao, Ran

AU - Luo, Jingting

AU - Yang, Xin

AU - Torun, Hamdi

AU - Zhou, Jian

AU - Huang, Shuyi

AU - Shi, Lin

AU - Gibson, Desmond

AU - Cooke, Michael

AU - Du, Hejun

AU - Dong, Shurong

AU - Luo, Jikui

AU - Fu, YongQing

PY - 2019/8/17

Y1 - 2019/8/17

N2 - Manipulating biological cells or microparticles in three dimensions (3D) is invaluable for many biomedical applications, and recently effective and rapid manipulations of microparticles in 2D and 3D within microchannels or chambers using surface acoustic waves (SAWs) with bulk piezoelectric materials have been reported. However, these are generally expensive, or brittle and cannot be easily integrated into a single lab-on-chip. In this paper, we realized microparticle/cell patterning and 3D manipulation of yeast cells inside a chamber with a height of 1 mm using thin film ZnO/Si SAW devices. Effects of SAW frequency, channel width and thickness on alignment of microparticles were firstly investigated, and positions of the microparticles in the direction of SAW propagation can be controlled precisely by changing the phase angle of the acoustic waves from the ZnO/Si SAW device. A numerical model has been developed to investigate the SAW acoustic field and the resulted 3D motions of microparticles under the acoustic radiation forces within the microchamber. Finally, we realized and observed the 3D patterning of yeast cells within the microchannel. Our work shows a great potential for acoustofluidic, neural network research and biomedical applications using the ZnO/Si SAW devices.

AB - Manipulating biological cells or microparticles in three dimensions (3D) is invaluable for many biomedical applications, and recently effective and rapid manipulations of microparticles in 2D and 3D within microchannels or chambers using surface acoustic waves (SAWs) with bulk piezoelectric materials have been reported. However, these are generally expensive, or brittle and cannot be easily integrated into a single lab-on-chip. In this paper, we realized microparticle/cell patterning and 3D manipulation of yeast cells inside a chamber with a height of 1 mm using thin film ZnO/Si SAW devices. Effects of SAW frequency, channel width and thickness on alignment of microparticles were firstly investigated, and positions of the microparticles in the direction of SAW propagation can be controlled precisely by changing the phase angle of the acoustic waves from the ZnO/Si SAW device. A numerical model has been developed to investigate the SAW acoustic field and the resulted 3D motions of microparticles under the acoustic radiation forces within the microchamber. Finally, we realized and observed the 3D patterning of yeast cells within the microchannel. Our work shows a great potential for acoustofluidic, neural network research and biomedical applications using the ZnO/Si SAW devices.

KW - Acoustofluidic

KW - ZnO

KW - 3D manipulation

KW - Yeast cell

KW - Lab on a chip

U2 - 10.1016/j.snb.2019.126991

DO - 10.1016/j.snb.2019.126991

M3 - Article

VL - 299

JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

SN - 0925-4005

M1 - 126991

ER -