2-furyl(phenyl)methanol isolated from Atractilis gummifera rhizome exhibits anti-leishmanial activity

Solene Deiva, Lindsay Ferguson, Mostafa E. Rateb, Roderick Williams, Federico Brucoli*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
22 Downloads (Pure)


We report for the first time the isolation of 2-furyl(phenyl)methanol (5) from the chloroform extracts of the Atractylis gummifera roots. A. gummifera is a thistle belonging to the Asteraceae family that produces the ent-kaurane diterpenoid glycoside atractyloside (ATR). ATR (1) was isolated and chemically modified to obtain its aglycone atractyligenin (2) and the methylated derivatives ATR-OMe (3) and genine-OMe (4). The compounds 1–5 were structurally characterised and evaluated against the intracellular amastigote, cultured within macrophages, and the extracellular promastigote of Leishmania donovani, the protozoan parasite responsible for the highly infective disease visceral leishmaniasis, which is fatal if untreated. The 2-furyl(phenyl)methanol 5 exhibited notable activity against the promastigote.
Original languageEnglish
Article number104420
Number of pages6
Early online date14 Nov 2019
Publication statusPublished - 31 Jan 2020


  • Antileishmanial agents
  • Ent-kaurane diterpenoids
  • Structural characterisation
  • Leishmania donovani
  • Luciferase assay
  • Phenyl-furan chemical scaffold


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