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Research Output 1996 2020

2020

2-furyl(phenyl)methanol isolated from Atractilis gummifera rhizome exhibits anti-leishmanial activity

Deiva, S., Ferguson, L., Rateb, M. E., Williams, R. & Brucoli, F., 31 Jan 2020, In : Fitoterapia. 140, 6 p., 104420.

Research output: Contribution to journalArticle

Atractyloside
Methanol
Kaurane Diterpenes
Diterpenes
Macrophages
2019
94 Downloads (Pure)

European propolis is highly active against trypanosomatids including Crithidia fasciculata

Alotaibi, A., Ebiloma, G. U., Williams, R., Alenezi, S., Donachie, A-M., Guillaume, S., Igoli, J. O., Fearnley, J., de Koning, H. P. & Watson, D., 6 Aug 2019, In : Scientific Reports. 9, 11 p., 11364 .

Research output: Contribution to journalArticle

Open Access
File
Crithidia fasciculata
Trypanosomatidae
propolis
Leishmania mexicana
Crithidia
estuarine sediment
Microbiota
Ecosystems
Ecosystem
Sediments
2018

Can legacy pollution influence antimicrobial resistance in estuarine sediments? the geochemical role!

Rodgers, K., McLellan, I., Peshkur, T., Williams, R., Tonner, R., Hursthouse, A. S., Knapp, C. W. & Henriquez, F. L., 2 Jul 2018, p. 96-96. 1 p.

Research output: Contribution to conferencePresentation

estuarine sediment
pollution
antibiotic resistance
antibiotics
public health
6 Citations (Scopus)
65 Downloads (Pure)

Can the legacy of industrial pollution influence antimicrobial resistance in estuarine sediments?

Rodgers, K., McLellan, I., Peshkur, T., Williams, R., Tonner, R., Hursthouse, A., Knapp, C. & Henriquez, F., 13 Oct 2018, In : Environmental Chemistry Letters. 17, 2, p. 595-607 13 p.

Research output: Contribution to journalLiterature review

Open Access
File
estuarine sediment
antibiotics
Sediments
Pollution
Security Measures
6 Citations (Scopus)
antibiotic resistance
estuary
pollution
gene
estuarine sediment
2017
31 Citations (Scopus)
2015
20 Citations (Scopus)

Metabolomic Analyses of Leishmania Reveal Multiple Species Differences and Large Differences in Amino Acid Metabolism

Westrop, G. D., Williams, R. A. M., Wang, L., Zhang, T., Watson, D. G., Silva, A. M. & Coombs, G. H., 2015, In : PLoS ONE. 10, 9, p. e0136891

Research output: Contribution to journalArticle

Open Access
Metabolomics
Leishmania
amino acid metabolism
metabolomics
Metabolites
50 Citations (Scopus)

Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion

Hurrell, B. P., Schuster, S., Grün, E., Coutaz, M., Williams, R. A., Held, W., Malissen, B., Malissen, M., Yousefi, S., Simon, H-U., Müller, A. J. & Tacchini-Cottier, F., May 2015, In : PLOS Pathogens. 11, 5, e1004929.

Research output: Contribution to journalArticle

Open Access
Leishmania mexicana
Parasites
Neutrophils
Neutrophil Infiltration
Communicable Disease Control
2014
19 Citations (Scopus)

Glycosome turnover in Leishmania major is mediated by autophagy

Cull, B., Prado Godinho, J. L., Fernandes Rodrigues, J. C., Frank, B., Schurigt, U., Williams, R. A. M., Coombs, G. H. & Mottram, J. C., Dec 2014, In : Autophagy. 10, 12, p. 2143-2157

Research output: Contribution to journalArticle

2013
21 Citations (Scopus)

Biochemical and Immunological Characterization of Toxoplasma gondii Macrophage Migration Inhibitory Factor

Sommerville, C., Richardson, J. M., Williams, R. A. M., Mottram, J. C., Roberts, C. W., Alexander, J. & Henriquez-Mui, F., 3 May 2013, In : Journal of Biological Chemistry. 288, 18, p. 12733-12741

Research output: Contribution to journalArticle

18 Citations (Scopus)

Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of Leishmania major

Williams, R. A. M., Mottram, J. C. & Coombs, G. H., 1 Feb 2013, In : Journal of Biological Chemistry. 288, 5, p. 3678-3690 13 p.

Research output: Contribution to journalArticle

Open Access
Leishmania major
Autophagy
Cysteine
Reactive Oxygen Species
Peptide Hydrolases

Peptidases in autophagy are therapeutic targets for Leishmaniasis

Williams, R. A. M., 17 Apr 2013, Trypanosomatid Diseases: Molecular Routes to Drug Discovery. Jäger, T., Koch, O. & Flohé, L. (eds.). Weinheim: Wiley-VCH Verlag, p. 351-364 14 p. (Drug Discovery in Infectious Diseases).

Research output: Chapter in Book/Report/Conference proceedingChapter

38 Citations (Scopus)

Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation

Tomlins, A. M., Ben-Rached, F., Williams, R. A. M., Proto, W. R., Coppens, I., Ruch, U., Gilberger, T. W., Coombs, G. H., Mottram, J. C., Mueller, S. & Langsley, G., 29 Aug 2013, In : Autophagy. 9, 10, p. 1540-1552 13 p.

Research output: Contribution to journalArticle

Open Access
2012
48 Citations (Scopus)

ATG5 Is Essential for ATG8-Dependent Autophagy and Mitochondrial Homeostasis in Leishmania major

Williams, R. A. M., Smith, T. K., Cull, B., Mottram, J. C. & Coombs, G. H., May 2012, In : PLOS Pathogens. 8, 5, e1002695.

Research output: Contribution to journalArticle

Open Access
27 Citations (Scopus)

The efficacy of aerosol treatment with non-ionic surfactant vesicles containing amphotericin B in rodent models of leishmaniasis and pulmonary aspergillosis infection

Alsaadi, M., Italia, J. L., Mullen, A. B., Kumar, M. N. V. R., Candlish, A. A., Williams, R. A. M., Shaw, C. D., Al Gawhari, F., Coombs, G. H., Wiese, M., Thomson, A. H., Puig-Sellart, M., Wallace, J., Sharp, A., Wheeler, L., Warn, P. & Carter, K. C., 28 Jun 2012, In : Journal of Controlled Release. 160, 3, p. 685-691

Research output: Contribution to journalArticle

2009
60 Citations (Scopus)

Characterization of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite Leishmania major

Williams, R. A. M., Woods, K. L., Juliano, L., Mottram, J. C. & Coombs, G. H., 16 Feb 2009, In : Autophagy. 5, 2, p. 159-172

Research output: Contribution to journalArticle

44 Citations (Scopus)

Two pathways for cysteine biosynthesis in Leishmania major

Williams, R. A. M., Westrop, G. D. & Coombs, G. H., 15 Jun 2009, In : Biochemical Journal. 420, p. 451-462

Research output: Contribution to journalArticle

2007
84 Citations (Scopus)

Protein turnover and differentiation in Leishmania

Besteiro, S., Williams, R. A. M., Coombs, G. H. & Mottram, J. C., Aug 2007, In : International Journal for Parasitology. 37, 10, p. 1063-75 13 p.

Research output: Contribution to journalArticle

Open Access
Leishmania
Parasites
Peptide Hydrolases
Proteins
Autophagy
2006
111 Citations (Scopus)

Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana

Williams, R. A., Tetley, L., Mottram, J. C. & Coombs, G. H., Aug 2006, In : Journal of Medical Microbiology. 61, 3, p. 655-74 20 p.

Research output: Contribution to journalArticle

Leishmania mexicana
Autophagy
Cysteine
Peptide Hydrolases
Serine
148 Citations (Scopus)

Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major

Besteiro, S., Williams, R. A. M., Morrison, L. S., Coombs, G. H. & Mottram, J. C., 21 Apr 2006, In : Journal of Biological Chemistry. 281, 16, p. 11384-96 13 p.

Research output: Contribution to journalArticle

Leishmania major
Endosomes
Autophagy
Sorting
Virulence
2003
60 Citations (Scopus)

3-mercaptopyruvate sulfurtransferase of leishmania contains an unusual C-terminal extension and is involved in thioredoxin and antioxidant metabolism

Williams, R. A. M., Kelly, S. M., Mottram, J. C. & Coombs, G. H., 17 Jan 2003, In : Journal of Biological Chemistry. 278, 3, p. 1480-1486 7 p.

Research output: Contribution to journalArticle

Thioredoxins
Leishmania
Metabolism
Antioxidants
Enzymes
32 Citations (Scopus)

The crystal structure of Leishmania major 3-mercaptopyruvate sulfurtransferase: a three-domain architecture with a serine protease-like triad at the active site

Alphey, M. S., Williams, R. A. M., Mottram, J. C., Coombs, G. H. & Hunter, W. N., 28 Nov 2003, In : Journal of Biological Chemistry. 278, 48, p. 48219-48227 9 p.

Research output: Contribution to journalArticle

Leishmania major
Thiosulfate Sulfurtransferase
Serine Proteases
Catalytic Domain
Crystal structure
1998
4 Citations (Scopus)
Sierra Leone
Tetanus
Malaria
Death Certificates
Perinatal Mortality
1997
10 Citations (Scopus)
Sierra Leone
Albendazole
Levamisole
Helminths
Necator
1996
23 Citations (Scopus)

Effects of albendazole on growth of primary school children and the prevalence and intensity of soil-transmitted helminths in Sierra Leone

Koroma, M. M., Williams, R. A., de la Have, R. & Hodges, M., Dec 1996, In : Journal of Tropical Pediatrics. 42, 6, p. 371-2 2 p.

Research output: Contribution to journalLetter