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Research Output

2020

2-furyl(phenyl)methanol isolated from Atractilis gummifera rhizome exhibits anti-leishmanial activity

Deiva, S., Ferguson, L., Rateb, M. E., Williams, R. & Brucoli, F., 31 Jan 2020, In : Fitoterapia. 140, 6 p., 104420.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
55 Downloads (Pure)

Alkylphosphocholines and quaternary ammonium compounds against Acanthamoeba keratitis

Mooney, R. & Williams, R., 31 Jul 2020, In : Journal of Ophthalmological Science. 2, 2, p. 5-14 10 p.

Research output: Contribution to journalReview article

Open Access
File
8 Downloads (Pure)

Drug combinations are effective anti-leishmanials against drug resistant Leishmania mexicana

Ahmed, H., Curtis, C. R., Tur-Gracia, S., Olatunji, T. O., Carter, K. C. & Williams, R. A. M., 2 Jul 2020, In : RSC Medicinal Chemistry. 11, 8, p. 905-912 8 p.

Research output: Contribution to journalArticle

Structure and antiparasitic activity relationship of alkylphosphocholine analogues against Leishmania donovani

Ahmed, H., Carter, K. C. & Williams, R. A. M., 24 Jul 2020, In : Microorganisms. 8, 8, 16 p., 1117.

Research output: Contribution to journalArticle

Open Access
File
8 Downloads (Pure)
2019

European propolis is highly active against trypanosomatids including Crithidia fasciculata

Alotaibi, A., Ebiloma, G. U., Williams, R., Alenezi, S., Donachie, A-M., Guillaume, S., Igoli, J. O., Fearnley, J., de Koning, H. P. & Watson, D., 6 Aug 2019, In : Scientific Reports. 9, 11 p., 11364 .

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
137 Downloads (Pure)
Open Access
File
2 Citations (Scopus)
30 Downloads (Pure)
2018

Can legacy pollution influence antimicrobial resistance in estuarine sediments? the geochemical role!

Rodgers, K., McLellan, I., Peshkur, T., Williams, R., Tonner, R., Hursthouse, A. S., Knapp, C. W. & Henriquez, F. L., 2 Jul 2018, p. 96-96. 1 p.

Research output: Contribution to conferencePresentation

Can the legacy of industrial pollution influence antimicrobial resistance in estuarine sediments?

Rodgers, K., McLellan, I., Peshkur, T., Williams, R., Tonner, R., Hursthouse, A., Knapp, C. & Henriquez, F., 13 Oct 2018, In : Environmental Chemistry Letters. 17, 2, p. 595-607 13 p.

Research output: Contribution to journalLiterature review

Open Access
File
8 Citations (Scopus)
108 Downloads (Pure)

Genes of past, present and future: does legacy pollution contribute to antibiotic resistance in industrialised estuaries?

Rodgers, K., McLellan, I., Hursthouse, A., Henriquez, F., Tonner, R., Peshkur, T., Knapp, C. & Williams, R., 26 Apr 2018.

Research output: Contribution to conferencePoster

11 Citations (Scopus)

Genes of past, present and future: does legacy pollution contribute to antibiotic resistance in industrialised estuaries?

Rodgers, K., Henriquez, F., McLellan, I., Hursthouse, A., Williams, R., Tonner, R., Peshkur, T. & Knapp, C., 12 Apr 2018.

Research output: Contribution to conferencePoster

2017

Genes of past, present and future: does legacy pollution contribute to antibiotic resistance in industrialised estuaries?

Rodgers, K., Hursthouse, A., McLellan, I., Henriquez, F., Williams, R., Tonner, R., Peshkur, T. & Knapp, C., 24 Nov 2017.

Research output: Contribution to conferencePoster

44 Citations (Scopus)
2015

Metabolomic Analyses of Leishmania Reveal Multiple Species Differences and Large Differences in Amino Acid Metabolism

Westrop, G. D., Williams, R. A. M., Wang, L., Zhang, T., Watson, D. G., Silva, A. M. & Coombs, G. H., 14 Sep 2015, In : PLoS ONE. 10, 9, p. e0136891

Research output: Contribution to journalArticle

Open Access
21 Citations (Scopus)

Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion

Hurrell, B. P., Schuster, S., Grün, E., Coutaz, M., Williams, R. A., Held, W., Malissen, B., Malissen, M., Yousefi, S., Simon, H-U., Müller, A. J. & Tacchini-Cottier, F., May 2015, In : PLOS Pathogens. 11, 5, e1004929.

Research output: Contribution to journalArticle

Open Access
55 Citations (Scopus)
2014

Glycosome turnover in Leishmania major is mediated by autophagy

Cull, B., Prado Godinho, J. L., Fernandes Rodrigues, J. C., Frank, B., Schurigt, U., Williams, R. A. M., Coombs, G. H. & Mottram, J. C., Dec 2014, In : Autophagy. 10, 12, p. 2143-2157

Research output: Contribution to journalArticle

23 Citations (Scopus)
2013

Biochemical and Immunological Characterization of Toxoplasma gondii Macrophage Migration Inhibitory Factor

Sommerville, C., Richardson, J. M., Williams, R. A. M., Mottram, J. C., Roberts, C. W., Alexander, J. & Henriquez-Mui, F., 3 May 2013, In : Journal of Biological Chemistry. 288, 18, p. 12733-12741

Research output: Contribution to journalArticle

26 Citations (Scopus)

Distinct roles in autophagy and importance in infectivity of the two ATG4 cysteine peptidases of Leishmania major

Williams, R. A. M., Mottram, J. C. & Coombs, G. H., 1 Feb 2013, In : Journal of Biological Chemistry. 288, 5, p. 3678-3690 13 p.

Research output: Contribution to journalArticle

Open Access
18 Citations (Scopus)

Peptidases in autophagy are therapeutic targets for Leishmaniasis

Williams, R. A. M., 17 Apr 2013, Trypanosomatid Diseases: Molecular Routes to Drug Discovery. Jäger, T., Koch, O. & Flohé, L. (eds.). Weinheim: Wiley-VCH Verlag, p. 351-364 14 p. (Drug Discovery in Infectious Diseases).

Research output: Chapter in Book/Report/Conference proceedingChapter

Plasmodium falciparum ATG8 implicated in both autophagy and apicoplast formation

Tomlins, A. M., Ben-Rached, F., Williams, R. A. M., Proto, W. R., Coppens, I., Ruch, U., Gilberger, T. W., Coombs, G. H., Mottram, J. C., Mueller, S. & Langsley, G., 29 Aug 2013, In : Autophagy. 9, 10, p. 1540-1552 13 p.

Research output: Contribution to journalArticle

Open Access
45 Citations (Scopus)
2012

ATG5 Is Essential for ATG8-Dependent Autophagy and Mitochondrial Homeostasis in Leishmania major

Williams, R. A. M., Smith, T. K., Cull, B., Mottram, J. C. & Coombs, G. H., May 2012, In : PLOS Pathogens. 8, 5, e1002695.

Research output: Contribution to journalArticle

Open Access
52 Citations (Scopus)

The efficacy of aerosol treatment with non-ionic surfactant vesicles containing amphotericin B in rodent models of leishmaniasis and pulmonary aspergillosis infection

Alsaadi, M., Italia, J. L., Mullen, A. B., Kumar, M. N. V. R., Candlish, A. A., Williams, R. A. M., Shaw, C. D., Al Gawhari, F., Coombs, G. H., Wiese, M., Thomson, A. H., Puig-Sellart, M., Wallace, J., Sharp, A., Wheeler, L., Warn, P. & Carter, K. C., 28 Jun 2012, In : Journal of Controlled Release. 160, 3, p. 685-691

Research output: Contribution to journalArticle

29 Citations (Scopus)
2009

Characterization of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite Leishmania major

Williams, R. A. M., Woods, K. L., Juliano, L., Mottram, J. C. & Coombs, G. H., 16 Feb 2009, In : Autophagy. 5, 2, p. 159-172

Research output: Contribution to journalArticle

61 Citations (Scopus)

Two pathways for cysteine biosynthesis in Leishmania major

Williams, R. A. M., Westrop, G. D. & Coombs, G. H., 15 Jun 2009, In : Biochemical Journal. 420, p. 451-462

Research output: Contribution to journalArticle

48 Citations (Scopus)
2007

Protein turnover and differentiation in Leishmania

Besteiro, S., Williams, R. A. M., Coombs, G. H. & Mottram, J. C., Aug 2007, In : International Journal for Parasitology. 37, 10, p. 1063-75 13 p.

Research output: Contribution to journalArticle

Open Access
89 Citations (Scopus)
2006

Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana

Williams, R. A., Tetley, L., Mottram, J. C. & Coombs, G. H., Aug 2006, In : Journal of Medical Microbiology. 61, 3, p. 655-74 20 p.

Research output: Contribution to journalArticle

116 Citations (Scopus)

Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major

Besteiro, S., Williams, R. A. M., Morrison, L. S., Coombs, G. H. & Mottram, J. C., 21 Apr 2006, In : Journal of Biological Chemistry. 281, 16, p. 11384-96 13 p.

Research output: Contribution to journalArticle

154 Citations (Scopus)
2003

3-mercaptopyruvate sulfurtransferase of leishmania contains an unusual C-terminal extension and is involved in thioredoxin and antioxidant metabolism

Williams, R. A. M., Kelly, S. M., Mottram, J. C. & Coombs, G. H., 17 Jan 2003, In : Journal of Biological Chemistry. 278, 3, p. 1480-1486 7 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

The crystal structure of Leishmania major 3-mercaptopyruvate sulfurtransferase: a three-domain architecture with a serine protease-like triad at the active site

Alphey, M. S., Williams, R. A. M., Mottram, J. C., Coombs, G. H. & Hunter, W. N., 28 Nov 2003, In : Journal of Biological Chemistry. 278, 48, p. 48219-48227 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
1998
4 Citations (Scopus)
1997
11 Citations (Scopus)
1996

Effects of albendazole on growth of primary school children and the prevalence and intensity of soil-transmitted helminths in Sierra Leone

Koroma, M. M., Williams, R. A., de la Have, R. & Hodges, M., Dec 1996, In : Journal of Tropical Pediatrics. 42, 6, p. 371-2 2 p.

Research output: Contribution to journalLetter

24 Citations (Scopus)