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Personal profile

Area of academic expertise - outline

Roderick Williams works on the molecular, cell biology and biochemistry of neglected and orphan parasitic protozoans such as Leishmania spp and Acanthamoeba spp. His primary research goal is to understand the molecular mechanisms by which the protozoa parasites, Leishmania and Acanthamoeba parasites undergo cellular remodelling during their complex life cycles to aid survival and virulence. He primarily focuses on essential proteins such as peptidases,  conjugating and deconjugating proteins and their respective adaptor molecules involved in cellular pathways that regulate the activities of post-translational modifications to, and the turnover of proteins e.g. sumoylation, autophagy.  He is also interested sterol and phospholipids biosynthesis, with a particular focus on natural and synthetic inhibitors, natural variation in the Leishmania metabolome in disease tropism and new methods for investigating the essentiality and druggability of essential targets important for disease progression, in Leishmania spp. More recently, he is investigating the enzymology of cellulose degradation for therapeutic and bioenergy solutions and the use of soil microbiome for metal bioremediation

Desired research direction

My ultimate goals are to (a) identify novel molecular mechanisms that can be exploited for the development of anti-parasite therapies and (b) utilise microbial cellulose degradation pathways and microbials to provide a sustainable bioenergy solution.

Current research activities

Current projects include: (a) Protein sumoylation and cell cycle progression of Leishmania, (b) The druggabbilty of enzymes involved in sterol and phospholipids biosynthesis in Leishmania spp and Acanthamoeba spp (c) Enzymology of cellulose degradation for therapeutic and bioenergy solutions (d) Metal bioremediation.

Target collaborative companies

Biotechnology Industry - Interested in working with companies seeking help with identifying targets and developing better therapy for tropical parasitic conditions and bioenergy solutions from cellulose degradation and microbial fuel cell

Target collaborative organisations

Collaborations with Universities of Glasgow, Strathclyde and York are ongoing, but I am also keen to develop new collaborations with other institutions within and outside the UK

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1996 2020

2-furyl(phenyl)methanol isolated from Atractilis gummifera rhizome exhibits anti-leishmanial activity

Deiva, S., Ferguson, L., Rateb, M. E., Williams, R. & Brucoli, F., 14 Nov 2019, In : Fitoterapia. 140, 6 p., 104420.

Research output: Contribution to journalArticle

Atractyloside
Methanol
Kaurane Diterpenes
Diterpenes
Macrophages
73 Downloads (Pure)

European propolis is highly active against trypanosomatids including Crithidia fasciculata

Alotaibi, A., Ebiloma, G. U., Williams, R., Alenezi, S., Donachie, A-M., Guillaume, S., Igoli, J. O., Fearnley, J., de Koning, H. P. & Watson, D., 6 Aug 2019, In : Scientific Reports. 9, 11 p., 11364 .

Research output: Contribution to journalArticle

Open Access
File
Crithidia fasciculata
Trypanosomatidae
propolis
Leishmania mexicana
Crithidia
estuarine sediment
Microbiota
Ecosystems
Ecosystem
Sediments

Can legacy pollution influence antimicrobial resistance in estuarine sediments? the geochemical role!

Rodgers, K., McLellan, I., Peshkur, T., Williams, R., Tonner, R., Hursthouse, A. S., Knapp, C. W. & Henriquez, F. L., 2 Jul 2018, p. 96-96. 1 p.

Research output: Contribution to conferencePresentation

estuarine sediment
pollution
antibiotic resistance
antibiotics
public health
34 Downloads (Pure)

Can the legacy of industrial pollution influence antimicrobial resistance in estuarine sediments?

Rodgers, K., McLellan, I., Peshkur, T., Williams, R., Tonner, R., Hursthouse, A., Knapp, C. & Henriquez, F., 13 Oct 2018, In : Environmental Chemistry Letters. 17, 2, p. 595-607 13 p.

Research output: Contribution to journalLiterature review

Open Access
File
estuarine sediment
antibiotics
Sediments
Pollution
Security Measures

Prizes

Carnegie vacation Studentship for Isla McCrone

Roderick Williams (Recipient), 10 May 2018

Prize: Fellowship awarded competitively

Genes of past, present and future: does legacy pollution contribute to antibiotic resistance in industrialised estuaries?

Kiri Rodgers (Recipient), Andrew Hursthouse (Recipient), Iain McLellan (Recipient), Fiona Henriquez (Recipient), Roderick Williams (Recipient), Rebecca Tonner (Recipient), Tatyana Peshkur (Recipient) & Charles Knapp (Recipient), 27 Apr 2018

Prize: Prize (including medals and awards)

Estuaries
Posters
Microbial Drug Resistance
Genes

Activities 2000 2019

British Society of Parasitology

Roderick Williams (Participant), Meshal Daalah (Invited speaker), Fiona Henriquez (Participant)
15 Apr 201917 Apr 2019

Activity: Participating in or organising an eventParticipation in conference

The Clyde’s Industrial History and its Impact on Antimicrobial Resistance

Kiri Rodgers (Speaker), Iain McLellan (Speaker), Tatyana Peshkur (Speaker), Roderick Williams (Speaker), Rebecca Tonner (Speaker), Charles Knapp (Speaker), Andrew Hursthouse (Speaker), Fiona Henriquez (Speaker)
4 Sep 2019

Activity: Talk or presentationOral presentation

Carnegie Scholars' Gathering 2019

Roderick Williams (Participant), Ronnie Mooney (Invited speaker), Fiona Henriquez (Participant)
28 Feb 2019

Activity: Participating in or organising an eventParticipation in conference

The Journal of Antibiotics (Journal)

Roderick Williams (Peer reviewer)
19 Apr 2018

Activity: Publication peer-review and editorial workEditorial activity

Press / Media

Profiles

Exosomes
Osteoarthritis
Cartilage
Cartilage Diseases
Chondrocytes