Research output per year
Research output per year
Accepting PhD Students
Research activity per year
The majority of my research experience and training has been in the area of cellular and molecular biology, specifically looking at haemopoietic diseases such as leukaemia and the effect of ageing on the cells of the immune system. I have many years experience in using cell models of disease to analyse the effects on growth factors, signalling pathways and gene expression profiles using techniques such as stem cell differentiation, proteomic analysis and molecular genetics techniques including transcriptome analysis and real-time PCR.
I am currently focused on projects examining how changes in gene expression profiles are involved in the pathogeneiss and progression of myeloproliferative neoplasms and myeloid leukamia. This is part of a collaborative body of work with researchers at the Paul O'Gorman Leukaemia Research Centre at Gartnavel Hospital in Glasgow. Examples of current projects include investigating the role of the Wnt pathway in leukaemia and specifically how changes to this signalling network manifest themselves in altered expression of downstream transcription factors such as LEF1, TCF3,4 & 7. Current projects are also investigating how isoform specific expression of transcription factors regulates progression of myeloid leukaemia.
My experience in using cell systems as disease models combined with advances in technology has given much greater capacity to quantify the changes that occur within the cell in processes such as gene expression and protein phosphorylation. The amount of data able to be generated within a short timeframe has increased exponentially in the past few years and has presented challenges associated with the ability to analyse and interpret the results obtained. I am currently working to increase my skills and training to allow a more bioinformatic approach to my research which should enable a more in-depth understanding of disease processes.
University of Glasgow
Paul O'Gorman Leukaemia Research Centre, Glasgow
MERCK KGaA
Stem Cell Technologies
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Meeting Abstract › peer-review
Research output: Contribution to journal › Article › peer-review
Freeburn, R. (Chair)
Activity: Participating in or organising an event › Participation in workshop, seminar, course
Lockhart, J., Litherland, G., Crilly, A., Goodyear, C., MacKenzie, A., McLellan, I., Bakhshi, A., Dunning, L., Freeburn, R., MacKay, W., Williams, C., McCallum, K., Bailo, M., Black, K., Short, B., Thomas, M. & Tarhini, F.
7/11/18
1 Media contribution
Press/Media: Other