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Personal profile

Area of academic expertise - outline

  • Drug Discovery from different natural sources incluiding marine and terrestrial organisms. Special emphasis is given to deep Sea and hyper-arid desert microbes in addition to microbial endophytes.
  • Structure elucidation of natural products using advanced one- and two-dimentional NMR and different High resolution MS techniques.
  • Applying different microbiological approaches such as OSMAC, microbial co-culture, and epigenetic modifiers for induction and isolation of novel microbial secondary metabolites from “cryptic gene clusters”.
  • Purification of complex mixtures of natural products using diverse chromatographic approaches mainly preparative HPLC and other chromatographic techniques such as VLC, SEC, SPE, and flash system.
  • GCMS analysis of volatile organic compounds from micro-organisms.

Current research activities

  • Isolation and characterization of bioactive natural products from hyper-arid Desert novel Actinomycetes
  • Isolation and characterization of bioactive natural products from marine endophytic fungi.
  • Microbial co-culture for induction of new secondary metabolites.
  • Optimization of fungal fermentation for Biofuel production.
  • Isolation of targeted bioactive plant natural products

 

Desired research direction

  • The Discovery of microbial natural products with potential for treatment of Neglected Tropical diseases, HIV and HCV, solid tumours, and senolytic agents.
  • The discovery of biofuel-producing fungi with potential industrial scale.

 

 

Target collaborative companies

  • Big and small Pharmaceutical companies
  • Big Research Institutes
  • Academic institutes in the UK, EU and Middle East

 

 

External positions

Honorary Research Fellow, University of Aberdeen

1 Oct 201530 Sep 2020

Keywords

  • QD Chemistry
  • Microbial Natural Product Chemistry
  • Structure elucidation of natural products

Fingerprint Dive into the research topics where Mostafa Rateb is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Streptomyces Medicine & Life Sciences
Endophytes Medicine & Life Sciences
Metabolites Chemical Compounds
Biological Products Medicine & Life Sciences
Indian Ocean Medicine & Life Sciences
Fungi Medicine & Life Sciences
Diketopiperazines Medicine & Life Sciences
Inhibitory Concentration 50 Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2007 2020

2-furyl(phenyl)methanol isolated from Atractilis gummifera rhizome exhibits anti-leishmanial activity

Deiva, S., Ferguson, L., Rateb, M. E., Williams, R. & Brucoli, F., 14 Nov 2019, In : Fitoterapia. 140, 6 p., 104420.

Research output: Contribution to journalArticle

Atractyloside
Methanol
Kaurane Diterpenes
Diterpenes
Macrophages

An online resource for marine fungi

Jones, E. B. G., Pang, K-L., Abdel-Wahab, M. A., Scholz, B., Hyde, K. D., Boekhout, T., Ebel, R., Rateb, M. E., Henderson, L., Sakayaroj, J., Suetrong, S., Dayarathne, M. C., Kumar, V., Raghukumar, S., Sridhar, K. R., Bahkali, A. H. A., Gleason, F. H. & Norphanphoun, C., 31 May 2019, In : Fungal Diversity. 96, 1, p. 347-433 87 p.

Research output: Contribution to journalReview article

fungus
resource
nomenclature
ecology
new taxon
78 Downloads (Pure)

Bioactive brominated oxindole alkaloids from the Red Sea sponge Callyspongia siphonella

El-Hawary, S. S., Sayed, A. M., Mohammed, R., Hassan, H. M., Rateb, M. E., Amin, E., Mohammed, T. A., El-Mesery, M., Bin Muhsinah, A., Alsayari, A., Wajant, H., Anany, M. A. & Abdelmohsen, U. R., 9 Aug 2019, In : Marine Drugs. 17, 8, 13 p., 465.

Research output: Contribution to journalArticle

Open Access
File
Callyspongia
Indian Ocean
Porifera
Microbial Sensitivity Tests
Alkaloids

Candelariella vitellina extract triggers in vitro and in vivo cell death through induction of apoptosis: a novel anticancer agent

El-Garawani, I. M., Elkhateeb, W. A., Zaghlol, G. M., Almeer, R. S., Ahmed, E. F., Rateb, M. E. & Abdel Moneim, A. E., 31 May 2019, In : Food and Chemical Toxicology. 127, p. 110-119 10 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Cell Death
Apoptosis
Lichens
Inhibitory Concentration 50
10 Downloads (Pure)

Characterization of natural bioactive compounds produced by isolated bacteria from compost of aromatic plants

El-Helw, N. O., El-Gendy, A. O., El-Gebaly, E., Hassan, H. M., Rateb, M. E. & El-Nesr, K. A., 28 Feb 2019, In : Journal of Applied Microbiology. 126, 2, p. 443-451 9 p.

Research output: Contribution to journalArticle

Open Access
File
Soil
Liquid Chromatography
Bacteria
Mass Spectrometry
Gram-Positive Bacteria

Prizes

Activities 2000 2019

referee/consultant for Academic Promotion Committees

Mostafa Rateb (Reviewer)
Mar 2019 → …

Activity: OtherTypes of External academic engagement - Contribution to the work of national or international committees and working groups

Marine Drugs (Journal)

Mostafa Rateb (Guest editor)
Dec 2019Sep 2020

Activity: Publication peer-review and editorial workEditorial activity

XVI International Symposium on Marine Natural Products | XI European Conference on Marine Natural Products

Mostafa Rateb (Participant)
Sep 2019

Activity: Participating in or organising an eventParticipation in conference

BIOPROSP-19

Mostafa Rateb (Participant)
Feb 2019

Activity: Participating in or organising an eventParticipation in conference

biomolecules (Journal)

Mostafa Rateb (Referee)
May 2019 → …

Activity: Publication peer-review and editorial workEditorial activity

Press / Media

Red Sea fungus yields leads for new epilepsy drugs

Mostafa Rateb

1/05/18

1 Media contribution

Press/Media: Research