20072020

Research output per year

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Personal profile

Area of academic expertise - outline

  • Drug Discovery from different natural sources incluiding marine and terrestrial organisms. Special emphasis is given to deep Sea and hyper-arid desert microbes in addition to microbial endophytes.
  • Structure elucidation of natural products using advanced one- and two-dimentional NMR and different High resolution MS techniques.
  • Applying different microbiological approaches such as OSMAC, microbial co-culture, and epigenetic modifiers for induction and isolation of novel microbial secondary metabolites from “cryptic gene clusters”.
  • Purification of complex mixtures of natural products using diverse chromatographic approaches mainly preparative HPLC and other chromatographic techniques such as VLC, SEC, SPE, and flash system.
  • GCMS analysis of volatile organic compounds from micro-organisms.

Current research activities

  • Isolation and characterization of bioactive natural products from hyper-arid Desert novel Actinomycetes
  • Isolation and characterization of bioactive natural products from marine endophytic fungi.
  • Microbial co-culture for induction of new secondary metabolites.
  • Optimization of fungal fermentation for Biofuel production.
  • Isolation of targeted bioactive plant natural products

 

Desired research direction

  • The Discovery of microbial natural products with potential for treatment of Neglected Tropical diseases, HIV and HCV, solid tumours, and senolytic agents.
  • The discovery of biofuel-producing fungi with potential industrial scale.

 

 

Target collaborative companies

  • Big and small Pharmaceutical companies
  • Big Research Institutes
  • Academic institutes in the UK, EU and Middle East

 

 

External positions

Honorary Research Fellow, University of Aberdeen

1 Oct 201530 Sep 2020

Keywords

  • QD Chemistry
  • Microbial Natural Product Chemistry
  • Structure elucidation of natural products

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Research Output

2-furyl(phenyl)methanol isolated from Atractilis gummifera rhizome exhibits anti-leishmanial activity

Deiva, S., Ferguson, L., Rateb, M. E., Williams, R. & Brucoli, F., 31 Jan 2020, In : Fitoterapia. 140, 6 p., 104420.

Research output: Contribution to journalArticle

  • Anti-inflammatory activity and chemical characterisation of Opuntia ficus-indica seed oil cultivated in Saudi Arabia

    Koshak, A. E., Abdallah, H. M., Esmat, A. & Rateb, M. E., 30 Apr 2020, In : Arabian Journal for Science and Engineering. 45, p. 4571-4578 8 p.

    Research output: Contribution to journalArticle

  • Bioassay-guided isolation, metabolic profiling, and docking studies of hyaluronidase inhibitors from Ravenala madagascariensis

    Mohamed, E. M., Hetta, M. H., Rateb, M. E., Selim, M. A., AboulMagd, A. M., Badria, F. A., Abdelmohsen, U. R., Alhadrami, H. A. & Hassan, H. M., 8 Apr 2020, In : Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry. 25, 7, 12 p., 1714.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 8 Downloads (Pure)

    Chemical composition and therapeutic potential of three Cycas species in brain damage and pancreatitis provoked by gamma-radiation exposure in rats

    Ismail, A., Hassan, H. M., Moawad, A. S., Abdel Fattah, S. M., Sherif, N. H., Abdelmohsen, U. R., Radwan, M. M., Rateb, M. E. & Hetta, M. H., 19 Feb 2020, In : Journal of Radiation Research and Applied Sciences. 13, 1, p. 200-214 15 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    9 Downloads (Pure)

    Discovery of two brominated oxindole alkaloids as staphylococcal DNA gyrase and pyruvate kinase inhibitors via inverse virtual screening

    Sayed, A. M., Alhadrami, H. A., El-Hawary, S. S., Mohammed, R., Hassan, H. M., Rateb, M. E., Ramadan Abdelmohsen, U. & Bakeer, W., 20 Feb 2020, In : Microorganisms. 8, 2, 14 p., 293.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 2 Citations (Scopus)
    15 Downloads (Pure)

    Prizes

    Activities

    referee/consultant for Academic Promotion Committees

    Mostafa Rateb (Reviewer)

    Mar 2019 → …

    Activity: OtherTypes of External academic engagement - Contribution to the work of national or international committees and working groups

    XVI International Symposium on Marine Natural Products | XI European Conference on Marine Natural Products

    Mostafa Rateb (Participant)

    Sep 2019

    Activity: Participating in or organising an eventParticipation in conference

    Marine Drugs (Journal)

    Mostafa Rateb (Guest editor)

    Dec 2019Sep 2020

    Activity: Publication peer-review and editorial workEditorial activity

    BIOPROSP-19

    Mostafa Rateb (Participant)

    Feb 2019

    Activity: Participating in or organising an eventParticipation in conference

    biomolecules (Journal)

    Mostafa Rateb (Referee)

    May 2019 → …

    Activity: Publication peer-review and editorial workEditorial activity

    Press / Media

    Red Sea fungus yields leads for new epilepsy drugs

    Mostafa Rateb

    1/05/18

    1 Media contribution

    Press/Media: Research