20072020

Research output per year

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Personal profile

Area of academic expertise - outline

  • Drug Discovery from different natural sources incluiding marine and terrestrial organisms. Special emphasis is given to deep Sea and hyper-arid desert microbes in addition to microbial endophytes.
  • Structure elucidation of natural products using advanced one- and two-dimentional NMR and different High resolution MS techniques.
  • Applying different microbiological approaches such as OSMAC, microbial co-culture, and epigenetic modifiers for induction and isolation of novel microbial secondary metabolites from “cryptic gene clusters”.
  • Purification of complex mixtures of natural products using diverse chromatographic approaches mainly preparative HPLC and other chromatographic techniques such as VLC, SEC, SPE, and flash system.
  • GCMS analysis of volatile organic compounds from micro-organisms.

Current research activities

  • Isolation and characterization of bioactive natural products from hyper-arid Desert novel Actinomycetes
  • Isolation and characterization of bioactive natural products from marine endophytic fungi.
  • Microbial co-culture for induction of new secondary metabolites.
  • Optimization of fungal fermentation for Biofuel production.
  • Isolation of targeted bioactive plant natural products

 

Desired research direction

  • The Discovery of microbial natural products with potential for treatment of Neglected Tropical diseases, HIV and HCV, solid tumours, and senolytic agents.
  • The discovery of biofuel-producing fungi with potential industrial scale.

 

 

Target collaborative companies

  • Big and small Pharmaceutical companies
  • Big Research Institutes
  • Academic institutes in the UK, EU and Middle East

 

 

External positions

Honorary Research Fellow, University of Aberdeen

1 Oct 201530 Sep 2020

Keywords

  • QD Chemistry
  • Microbial Natural Product Chemistry
  • Structure elucidation of natural products

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Research Output

2-furyl(phenyl)methanol isolated from Atractilis gummifera rhizome exhibits anti-leishmanial activity

Deiva, S., Ferguson, L., Rateb, M. E., Williams, R. & Brucoli, F., 31 Jan 2020, In : Fitoterapia. 140, 6 p., 104420.

Research output: Contribution to journalArticle

  • Chemical composition and therapeutic potential of three Cycas species in brain damage and pancreatitis provoked by gamma-radiation exposure in rats

    Ismail, A., Hassan, H. M., Moawad, A. S., Abdel Fattah, S. M., Sherif, N. H., Abdelmohsen, U. R., Radwan, M. M., Rateb, M. E. & Hetta, M. H., 19 Feb 2020, In : Journal of Radiation Research and Applied Sciences. 13, 1, p. 200-214 15 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    1 Downloads (Pure)

    Discovery of two brominated oxindole alkaloids as staphylococcal DNA gyrase and pyruvate kinase inhibitors via inverse virtual screening

    Sayed, A. M., Alhadrami, H. A., El-Hawary, S. S., Mohammed, R., Hassan, H. M., Rateb, M. E., Ramadan Abdelmohsen, U. & Bakeer, W., 20 Feb 2020, In : Microorganisms. 8, 2, 14 p., 293.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 10 Downloads (Pure)

    Egyptian fungal antibiotic metabolites-from pharaohs to modern textiles

    Soldatou, S., Qader, M. M., Pavesi, C., Miranda, K. J., Diyaolou, O. A., Hamed, A. A., Rateb, M. E. & Ebel, R., 6 Jan 2020, In : Marine Drugs. 18, 1, p. 59-59 1 p.

    Research output: Contribution to journalMeeting Abstract

    Open Access
    File
    6 Downloads (Pure)

    Induction of cryptic antifungal pulicatin derivatives from Pantoea agglomerans by microbial co-culture

    Thissera, B., Alhadrami, H. A., Hassan, M. H. A., Hassan, H. M., Behery, F. A., Bawazeer, M., Yaseen, M., Belbahri, L. & Rateb, M. E., 10 Feb 2020, In : Biomolecules. 10, 2, 16 p., 268.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 8 Downloads (Pure)

    Prizes

    Activities

    referee/consultant for Academic Promotion Committees

    Mostafa Rateb (Reviewer)
    Mar 2019 → …

    Activity: OtherTypes of External academic engagement - Contribution to the work of national or international committees and working groups

    Marine Drugs (Journal)

    Mostafa Rateb (Guest editor)
    Dec 2019Sep 2020

    Activity: Publication peer-review and editorial workEditorial activity

    XVI International Symposium on Marine Natural Products | XI European Conference on Marine Natural Products

    Mostafa Rateb (Participant)
    Sep 2019

    Activity: Participating in or organising an eventParticipation in conference

    biomolecules (Journal)

    Mostafa Rateb (Referee)
    May 2019 → …

    Activity: Publication peer-review and editorial workEditorial activity

    BIOPROSP-19

    Mostafa Rateb (Participant)
    Feb 2019

    Activity: Participating in or organising an eventParticipation in conference

    Press / Media

    Red Sea fungus yields leads for new epilepsy drugs

    Mostafa Rateb

    1/05/18

    1 Media contribution

    Press/Media: Research