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Personal profile

Area of academic expertise - outline

  • Drug Discovery from different natural sources incluiding marine and terrestrial organisms. Special emphasis is given to deep Sea and hyper-arid desert microbes in addition to microbial endophytes.
  • Structure elucidation of natural products using advanced one- and two-dimentional NMR and different High resolution MS techniques.
  • Applying different microbiological approaches such as OSMAC, microbial co-culture, and epigenetic modifiers for induction and isolation of novel microbial secondary metabolites from “cryptic gene clusters”.
  • Purification of complex mixtures of natural products using diverse chromatographic approaches mainly preparative HPLC and other chromatographic techniques such as VLC, SEC, SPE, and flash system.
  • GCMS analysis of volatile organic compounds from micro-organisms.

Current research activities

  • Isolation and characterization of bioactive natural products from hyper-arid Desert novel Actinomycetes
  • Isolation and characterization of bioactive natural products from marine endophytic fungi.
  • Microbial co-culture for induction of new secondary metabolites.
  • Optimization of fungal fermentation for Biofuel production.
  • Isolation of targeted bioactive plant natural products

 

Desired research direction

  • The Discovery of microbial natural products with potential for treatment of Neglected Tropical diseases, HIV and HCV, solid tumours, and senolytic agents.
  • The discovery of biofuel-producing fungi with potential industrial scale.

 

 

Target collaborative companies

  • Big and small Pharmaceutical companies
  • Big Research Institutes
  • Academic institutes in the UK, EU and Middle East

 

 

External positions

Honorary Research Fellow, University of Aberdeen

1 Oct 201530 Sep 2020

Keywords

  • QD Chemistry
  • Microbial Natural Product Chemistry
  • Structure elucidation of natural products

Fingerprint Dive into the research topics where Mostafa Rateb is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Streptomyces Medicine & Life Sciences
Endophytes Medicine & Life Sciences
Metabolites Chemical Compounds
Biological Products Medicine & Life Sciences
Indian Ocean Medicine & Life Sciences
Fungi Medicine & Life Sciences
Diketopiperazines Medicine & Life Sciences
Inhibitory Concentration 50 Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2007 2019

An online resource for marine fungi

Jones, E. B. G., Pang, K-L., Abdel-Wahab, M. A., Scholz, B., Hyde, K. D., Boekhout, T., Ebel, R., Rateb, M. E., Henderson, L., Sakayaroj, J., Suetrong, S., Dayarathne, M. C., Kumar, V., Raghukumar, S., Sridhar, K. R., Bahkali, A. H. A., Gleason, F. H. & Norphanphoun, C., 31 May 2019, In : Fungal Diversity. 96, 1, p. 347-433 87 p.

Research output: Contribution to journalArticle

fungus
resource
nomenclature
ecology
new taxon

Candelariella vitellina extract triggers in vitro and in vivo cell death through induction of apoptosis: a novel anticancer agent

El-Garawani, I. M., Elkhateeb, W. A., Zaghlol, G. M., Almeer, R. S., Ahmed, E. F., Rateb, M. E. & Abdel Moneim, A. E., 31 May 2019, In : Food and Chemical Toxicology. 127, p. 110-119 10 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Cell Death
Apoptosis
Lichens
Inhibitory Concentration 50
2 Downloads (Pure)

Chemical profiling and biological screening of some River Nile derived-microorganisms

Lotfy, M. M., Hassan, H. M., Mohammed, R., Hetta, M., El-Gendy, A. O., Rateb, M. E., Zaki, M. A. & Gamaleldin, N. M., 12 Apr 2019, In : Frontiers in Microbiology. 10, 10 p., 787.

Research output: Contribution to journalArticle

Open Access
File
Plasmodium falciparum
Rivers
Leishmania donovani
Chloroquine
Antimalarials

Discovery of kirromycins with anti- wolbachia activity from streptomyces sp. CB00686

Xu, Z., Fang, S-M., Bakowski, M. A., Rateb, M. E., Yang, D., Zhu, X., Huang, Y., Zhao, L-X., Jiang, Y., Duan, Y., Hull, M. V., McNamara, C. W. & Shen, B., 10 May 2019, In : ACS Chemical Biology. 14, 6, p. 1174-1182 9 p.

Research output: Contribution to journalArticle

Wolbachia
Streptomyces
Doxycycline
Inhibitory Concentration 50
Brugia pahangi

New antiproliferative cembrane diterpenes from the Red Sea sarcophyton species

Hassan, H. M., Rateb, M. E., Hassan, M. H., Sayed, A. M., Shabana, S., Raslan, M., Amin, E., Behery, F. A., Ahmed, O. M., Bin Muhsinah, A., Gulder, T. A. M. & Ramadan Abdelmohsen, U., 11 Jul 2019, In : Marine Drugs. 17, 7, 411.

Research output: Contribution to journalArticle

Open Access
File
Indian Ocean
Anthozoa
Diterpenes
Liquid Chromatography
Inhibitory Concentration 50

Activities 2000 2018

Elsevier Academic Press Inc (Publisher)

Mostafa Rateb (Peer reviewer)
Nov 2018 → …

Activity: Publication peer-review and editorial workPublication peer-review

Journal of Applied Microbiology (Journal)

Mostafa Rateb (Peer reviewer)
2018 → …

Activity: Publication peer-review and editorial workPublication peer-review

30th International Symposium on the Chemistry of Natural Products

Mostafa Rateb (Speaker), Gaia Burgio (Participant)
25 Nov 201829 Nov 2018

Activity: Participating in or organising an eventParticipation in conference

microbiological research (Journal)

Mostafa Rateb (Peer reviewer)
2018 → …

Activity: Publication peer-review and editorial workPublication peer-review

Biomedicine & Pharmacotherapy (Journal)

Mostafa Rateb (Peer reviewer)
2018 → …

Activity: Publication peer-review and editorial workPublication peer-review

Profiles

Disinfectants
Disinfection
Clostridium
Steel
Copper
Endophytes
metabolites
Metabolites
activity (biology)
industrial plants