20072019
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Personal profile

Area of academic expertise - outline

  • Drug Discovery from different natural sources incluiding marine and terrestrial organisms. Special emphasis is given to deep Sea and hyper-arid desert microbes in addition to microbial endophytes.
  • Structure elucidation of natural products using advanced one- and two-dimentional NMR and different High resolution MS techniques.
  • Applying different microbiological approaches such as OSMAC, microbial co-culture, and epigenetic modifiers for induction and isolation of novel microbial secondary metabolites from “cryptic gene clusters”.
  • Purification of complex mixtures of natural products using diverse chromatographic approaches mainly preparative HPLC and other chromatographic techniques such as VLC, SEC, SPE, and flash system.
  • GCMS analysis of volatile organic compounds from micro-organisms.

Current research activities

  • Isolation and characterization of bioactive natural products from hyper-arid Desert novel Actinomycetes
  • Isolation and characterization of bioactive natural products from marine endophytic fungi.
  • Microbial co-culture for induction of new secondary metabolites.
  • Optimization of fungal fermentation for Biofuel production.
  • Isolation of targeted bioactive plant natural products

 

Desired research direction

  • The Discovery of microbial natural products with potential for treatment of Neglected Tropical diseases, HIV and HCV, solid tumours, and senolytic agents.
  • The discovery of biofuel-producing fungi with potential industrial scale.

 

 

Target collaborative companies

  • Big and small Pharmaceutical companies
  • Big Research Institutes
  • Academic institutes in the UK, EU and Middle East

 

 

External positions

Honorary Research Fellow, University of Aberdeen

1 Oct 201530 Sep 2020

Keywords

  • QD Chemistry
  • Microbial Natural Product Chemistry
  • Structure elucidation of natural products

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Streptomyces Medicine & Life Sciences
Endophytes Medicine & Life Sciences
Biological Products Medicine & Life Sciences
Metabolites Chemical Compounds
Diketopiperazines Medicine & Life Sciences
Fungi Medicine & Life Sciences
Indian Ocean Medicine & Life Sciences
Actinobacteria Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2007 2019

Screening for fusarium antagonistic bacteria from contrasting niches designated the endophyte bacillus halotolerans as plant warden against fusarium

Slama, H. B., Cherif-Silini, H., Chenari Bouket, A., Qader, M., Silini, A., Yahiaoui, B., Alenezi, F. N., Luptakova, L., Triki, M. A., Vallat, A., Oszako, T., Rateb, M. E. & Belbahri, L. 11 Jan 2019 In : Frontiers in Microbiology. 9, 24 p., 3236

Research output: Contribution to journalArticle

Open Access
Endophytes
Fusarium
Bacillus
Bacteria
Olea

Asenjonamides A-C, antibacterial metabolites isolated from Streptomyces asenjonii strain KNN 42.f from an extreme-hyper arid Atacama Desert soil

Abdelkader, M. S. A., Philippon, T., Asenjo, J. A., Bull, A. T., Goodfellow, M., Ebel, R., Jaspars, M. & Rateb, M. E. 23 Jan 2018 In : The Journal of Antibiotics.

Research output: Contribution to journalArticle

Open Access
File
Diketopiperazines
Chile
Streptomyces
Glycosides
Soil

Balanites aegyptiaca ameliorates insulin secretion and decreases pancreatic apoptosis in diabetic rats: rle of SAPK/JNK pathway

Hassanin, K. M. A., Mahmoud, M. O., Hassan, H. M., Abdel-Razik, A-R. H., Aziz, L. N. & Rateb, M. E. 1 Jun 2018 In : Biomedicine & Pharmacotherapy. 102, p. 1084 - 1091

Research output: Contribution to journalArticle

Balanites
MAP Kinase Signaling System
Insulin
Apoptosis
JNK Mitogen-Activated Protein Kinases

Characterization of natural bioactive compounds produced by isolated bacteria from compost of aromatic plants

El-Helw, N. O., El-Gendy, A. O., El-Gebaly, E., Hassan, H. M., Rateb, M. E. & El-Nesr, K. A. 24 Aug 2018 In : Journal of Applied Microbiology.

Research output: Contribution to journalArticle

Soil
Liquid Chromatography
Bacteria
Mass Spectrometry
Gram-Positive Bacteria

Current status and future opportunities of omics tools in mycotoxin research

Eshelli, M., Qader, M. M., Jambi, E. J., Hursthouse, A. S. & Rateb, M. E. 26 Oct 2018 In : Toxins. 10, 11, 26 p., 433

Research output: Contribution to journalArticle

Open Access
File
Mycotoxins
Research
Contamination
Metabolites
Patulin

Activities 2000 2018

Biomedicine & Pharmacotherapy (Journal)

Rateb, M. (Peer reviewer)
2018 → …

Activity: Publication peer-review

30th International Symposium on the Chemistry of Natural Products

Rateb, M. (Speaker), Burgio, G. (Participant)
25 Nov 201829 Nov 2018

Activity: Participation in conference

microbiological research (Journal)

Rateb, M. (Peer reviewer)
2018 → …

Activity: Publication peer-review

Ist Euroindoamerican Natural Products Meeting

Rateb, M. (Speaker), Thissera, B. (Participant)
29 May 20181 Jun 2018

Activity: Participation in conference

Elsevier Academic Press Inc (Publisher)

Rateb, M. (Peer reviewer)
Nov 2018 → …

Activity: Publication peer-review

Profiles

Majed Bawazeer

Disinfectants
Disinfection
Clostridium
Steel
Copper

Gaia Burgio

Endophytes
Trichoderma
Fusarium
Liquid Chromatography
Gas Chromatography-Mass Spectrometry