Lynette Dunning

Research output

Research output per year 2003 2018 2019 2020 2021

• 17 Meeting Abstract
• 11 Article
• 5 Poster
• 1 Conference contribution
• 2 More
  • 1 Abstract
  • 1 Review article

Research output per year

Research output per year

Search results

• 2020

  Murine airway bronchodilation via Proteinase Activated Receptor 2

  Black, K., MacKenzie, A., Dunning, L., Crilly, A., Brzeszczyńska, J., McGarvey, L., Thornbury, K., Goodyear, C. S., Lockhart, J. C. & Litherland, G. J., 28 Oct 2020, In: European Respiratory Journal. 56, Supplement 64, 1895.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  File

  • PAR-2 Receptor 100%
  • Smooth Muscle 30%
  • Muscle Relaxation 21%
  • Chronic Obstructive Pulmonary Disease 15%
  • Trypsin 11%
  1 Downloads (Pure)

• Protease activated receptor 2 (PAR2) antagonism reduces pro-inflammatory cytokine production in bronchial epithelial cells

  Bailo, M., Dunning, L., Brzeszczynska, J., McIntosh, K., Plevin, R., Martin, S. L., Sergeant, G. P., Goodyear, C. S., Litherland, G. S., Lockhart, J. C. & Crilly, A., 28 Oct 2020, In: European Respiratory Journal. 56, Supplement 64, 2292.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  File

  • PAR-2 Receptor 100%
  • AZ8838 59%
  • Epithelial Cells 49%
  • Cytokines 43%
  • Chronic Obstructive Pulmonary Disease 34%

• Regulation of lung autophagy by proteinase-activated receptor 2 activation

  Mccallum, K., Dunning, L., Mcgarvey, L., Hollywood, M., Brzeszczynska, J., Goodyear, C., Lockhart, J., Crilly, A. & Litherland, G., 15 Apr 2020, In: ERJ Open Research. 6, suppl 5, 75.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  File

  • PAR-2 Receptor 100%
  • Autophagy 66%
  • Lung 37%
  • Premature Aging 26%
  • Chronic Obstructive Pulmonary Disease 26%
  3 Downloads (Pure)

• Repeated exposure to hydrogen peroxide enhances TGF-ß and LPS dependent inflammatory responses in BEAS-2B cells

  Tarhini, F., Dunning, L., Crilly, A., Brzeszczyńska, J., McGarvey, L., Thornbury, K., Goodyear, C. S., Lockhart, J. C. & Litherland, G. J., 28 Oct 2020, In: European Respiratory Journal. 56, Supplement 64, 607.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  File

  • Hydrogen Peroxide 100%
  • Interleukin-8 95%
  • Chronic Obstructive Pulmonary Disease 88%
  • Interleukin-6 76%
  • Oxidants 52%
• 2019

  Enhanced airway smooth muscle relaxation via proteinase activated receptor 2

  Black, K., MacKenzie, A., Dunning, L., Crilly, A., Brzeszczynska, J., McGarvey, L., Thornbury, K., Goodyear, C. S., Lockhart, J. C. & Litherland, G. J., 22 Nov 2019, In: Irish Journal of Medical Science. 188, SUPPL 10, p. 286-286 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  File
  2 Downloads (Pure)

• PAR2 accelerates osteoarthritis-like joint changes in a murine model of post-traumatic osteoarthritis

  Goodyear, C., McCulloch, K., Huesa, C., Dunning, L., van 't Hof, R. & Lockhart, J., 27 Jun 2019, In: Annals of the Rheumatic Diseases. 78, Issue Suppl 2, p. 110-110 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  • mouse F2rl1 protein 100%
  • PAR-2 Receptor 76%
  • Meniscus 72%
  • Tibial Meniscus 56%
  • Osteophyte 55%

• Proteinase activated receptor-2 induced autophagy dysregulation

  McCallum, K., Dunning, L., McGarvey, L., Hollywood, M., Brzeszczynska, J., Crilly, A., Lockhart, JC. & Litherland, GJ., 12 Nov 2019, In: THORAX. 74, Supplement 1, 1 p., A49.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  File

  • PAR-2 Receptor 100%
  • Autophagy 66%
  • Chronic Obstructive Pulmonary Disease 27%
  • Lung 24%
  • Epithelial Cells 22%
  1 Downloads (Pure)

• Proteinase activated receptor 2 modulates expression of autophagy markers in murine lungs

  McCallum, K., Dunning, L., McGarvey, L., Hollywood, M., Goodyear, C. S., Brzeszczynska, J., Crilly, A., Lockhart, J. C. & Litherland, G. J., 22 Nov 2019, In: Irish Journal of Medical Science. 188, SUPPL 10, p. S270-S270 1 p., 2.6.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  • PAR-2 Receptor 100%
  • Autophagy 66%
  • Lung 37%
  • Premature Aging 26%
  • Proteinase-Activated Receptors 14%

• Reduction of inflammatory cytokine production in chronic obstructive pulmonary disease (COPD) epithelial cells by protease activated receptor 2 (PAR2) antagonism

  Bailo, M., Dunning, L., Brzeszczynska, J., McIntosh, K., Plevin, R., Martin, SL., Sergeant, GP., Goodyear, CS., Litherland, GJ., Lockhart, JC. & Crilly, A., 12 Nov 2019, In: THORAX. 74, p. A62-A63 2 p., S100.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  • PAR-2 Receptor 100%
  • Chronic Obstructive Pulmonary Disease 61%
  • matriptase 52%
  • Epithelial Cells 49%
  • Cytokines 43%

• Understanding PAR2 matriptase ENaC crosstalk in the lung: implications for COPD

  Bailo, M., Dunning, L., Brzeszczynska, J., Martin, S. L., Sergeant, G. P., Goodyear, C. S., Litherland, G. J., Lockhart, J. C. & Crilly, A., 30 Nov 2019, In: Irish Journal of Medical Science. 188, SUPPL 10, p. 268-269 2 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review
• 2018

  Assessment of the effects of exercise on a murine model of OA

  Huesa, C., Dunning, L., Macdougall, K., Ortiz, A., Villaluz, M. M., Fegen, M., Crilly, A., Litherland, G., MacKenzie, A., van't Hof, R., Goodyear, C. & Lockhart, J., 30 Apr 2018, In: Osteoarthritis and Cartilage. 26, Supplement 1, p. s68 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  • Pathology 100%
  • Tibial Meniscus 93%
  • Surgery 89%
  • Osteoarthritis 78%
  • Bone 63%

• Investigating the matriptase-PAR2-ENaC axis in lung epithelial cells: potential role in COPD pathogenesis

  Lockhart, J., Bailo, M., McCallum, K., Dunning, L., Stankovic, M., Reihill, J., Sergeant, G., Goodyear, C. & Litherland, G., 8 Oct 2018, In: Irish Journal of Medical Science. 187, Supplement 8, p. S249 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  File

  • matriptase 100%
  • PAR-2 Receptor 85%
  • Chronic Obstructive Pulmonary Disease 52%
  • Epithelial Cells 42%
  • Lung 31%
  3 Downloads (Pure)

• Proteinase activated receptor 2 (PAR2) modulation of airway smooth muscle function

  Black, K., MacKenzie, A., Dunning, L., Crilly, A., McGarvey, L., Thornbury, K., Goodyear, C., Lockhart, J. & Litherland, G., 8 Oct 2018, In: Irish Journal of Medical Science. 187, Supplement 8, p. S249-S249 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  File

  • PAR-2 Receptor 100%
  • Smooth Muscle 61%
  • Chronic Obstructive Pulmonary Disease 35%
  • Lung 15%
  • Muscle Tonus 12%
  67 Downloads (Pure)

• Proteinase activated receptor-2 and autophagy regulation in airway epithelia cells

  McCallum, K., Bailo, M., Dunning, L., Stankovic, M., McGarvey, L., Hollywood, M., Goodyear, C. S., Crilly, A., Lockhart, J. C. & Litherland, G. J., 8 Oct 2018, In: Irish Journal of Medical Science. 187, Supplement 8, p. S272-S273 2 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

  File

  • PAR-2 Receptor 100%
  • Autophagy 66%
  • Epithelium 53%
  • Lung 37%
  • Premature Aging 30%
• 2016

  Proteinase-activated Receptor 2: Potential Role in Osteoarthritic Entheseal Pathology

  Ortiz, A., Dunning, L., Huesa, C., Ferrell, W. R., McInnes, I. B., Lockhart, J., Millar, N. L., Goodyear, C. S. & Crilly, A., 27 Oct 2016, (E-pub ahead of print) In: Orthopaedic Proceedings. 98-B, Suppl. 16

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access
• 2015

  Differential Inflammatory Profile in Experimental Models of Arthritis

  Ortiz, A. C., Crilly, A., Dunning, L., Huesa, C., Goodyear, C. S., Lockhart, J. C., Ferrell, W. R. & McInnes, I. B., Oct 2015, In: Arthritis & Rheumatology. 67, 1139.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access

• Microrna Biomarker Signature in Osteoarthritis

  Bennett, L. A., Coleman, T., Ferrell, W., Lockhart, J., Huesa, C., Dunning, L., Jones, B., Blyth, M., McInnes, I. B., Kurowska-Stolarska, M. & Goodyear, C. S., Oct 2015, In: Arthritis & Rheumatology. 67, 2398.

  Research output: Contribution to journal › Meeting Abstract › peer-review

  Open Access