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Lynette Dunning

Mrs

20032019

Research output per year

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Research Output

2003

Essential role for proteinase activated receptor-2 in arthritis

Ferrell, W. R., Lockhart, J. C., Kelso, E. B., Dunning, L., Plevin, R., Meek, S. E., Smith, A. J. H., Hunter, G. D., McLean, J. S., McGarry, F., Ramage, R., Jiang, L., Kanke, T. & Kawagoe, J., 2003, In : The Journal of Clinical Investigation. 111, p. 35-41 7 p.

Research output: Contribution to journalArticle

Open Access
273 Citations (Scopus)
2006

Therapeutic promise of proteinase-activated receptor-2 antagonism in joint inflammation

Kelso, E. B., Lockhart, J. C., Hembrough, T., Dunning, L., Plevin, R., Hollenberg, M. D., Sommerhoff, C. P., McLean, J. S. & Ferrell, W. R., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316, 3, p. 1017-1024 8 p.

Research output: Contribution to journalArticle

152 Citations (Scopus)
2007

Expression and pro-inflammatory role of proteinase-activated receptor 2 in rheumatoid synovium: ex vivo studies suing a novel proteinase-activated receptor-2 antagonist.

Kelso, E. B., Ferrell, W. R., Lockhart, J., Elias-Jones, I., Hembrough, T., Dunning, L., Gracie, J. A. & McInness, I. B., 2007, In : Arthritis & Rheumatology. 56, 3, p. 765-771 7 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)
2009

A model of chronic monoarthritis impairs EDHF but not NO activity in the saphenous artery of the rat

MacKenzie, A., Dunning, L., Ferrell, W. R. & Lockhart, J., Dec 2009, Proceedings of the British Pharmacological Society at http://www.pA2online.org/abstracts/Vol7Issue4abst004P.pdf . British Pharmacological Society, (pA2 Online; vol. 7, no. 4).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
2012

Correlation of protease-activated receptor-2 expression and synovitis in rheumatoid and osteoarthritis

Tindell, A. G., Kelso, E. B., Ferrell, W. R., Lockhart, J. C., Walsh, D. A., Dunning, L. & McInnes, I. B., Oct 2012, In : Rheumatology International. 32, 10, p. 3077-86 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Immunomodulatory role of proteinase-activated receptor-2

Crilly, A., Palmer, H., Nickdel, M. B., Dunning, L., Lockhart, J. C., Plevin, R., Mcinnes, I. B. & Ferrell, W. R., May 2012, In : Annals of the Rheumatic Diseases. 71, 9, p. 1559-1566 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

PAR(2) expression in peripheral blood monocytes of patients with rheumatoid arthritis

Crilly, A., Burns, E., Nickdel, M. B., Lockhart, J. C., Perry, M. E., Ferrell, P. W., Baxter, D., Dale, J., Dunning, L., Wilson, H., Nijjar, J. S., Gracie, J. A., Ferrell, W. R. & McInnes, I. B., Jun 2012, In : Annals of the Rheumatic Diseases. 71, 6, p. 1049-1054

Research output: Contribution to journalArticle

12 Citations (Scopus)
2013
8 Citations (Scopus)
2015

Differential Inflammatory Profile in Experimental Models of Arthritis

Ortiz, A. C., Crilly, A., Dunning, L., Huesa, C., Goodyear, C. S., Lockhart, J. C., Ferrell, W. R. & McInnes, I. B., Oct 2015, In : Arthritis & Rheumatology. 67, 1139.

Research output: Contribution to journalMeeting Abstract

Open Access

Microrna Biomarker Signature in Osteoarthritis

Bennett, L. A., Coleman, T., Ferrell, W., Lockhart, J., Huesa, C., Dunning, L., Jones, B., Blyth, M., McInnes, I. B., Kurowska-Stolarska, M. & Goodyear, C. S., Oct 2015, In : Arthritis & Rheumatology. 67, 2398.

Research output: Contribution to journalMeeting Abstract

Open Access
2016

Proteinase-activated Receptor 2: Potential Role in Osteoarthritic Entheseal Pathology

Ortiz, A., Dunning, L., Huesa, C., Ferrell, W. R., McInnes, I. B., Lockhart, J., Millar, N. L., Goodyear, C. S. & Crilly, A., 27 Oct 2016, In : Orthopaedic Proceedings. 98-B, Suppl. 16

Research output: Contribution to journalMeeting Abstract

Open Access

Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology

Huesa, C., Ortiz, A. C., Dunning, L., McGavin, L., Bennett, L., McIntosh, K., Crilly, A., Kurowska-Stolarska, M., Plevin, R., van 't Hof, R. J., Rowan, A. D., McInnes, I. B., Goodyear, C. S., Lockhart, J. C. & Ferrell, W. R., 11 Oct 2016, In : Annals of the Rheumatic Diseases. 75, 11, p. 1989-1997

Research output: Contribution to journalArticle

Open Access
25 Citations (Scopus)
2017
Open Access
File
2 Citations (Scopus)
117 Downloads (Pure)
2018

Accelerated osteoarthritic-like symptoms in a novel dual injury model combining destabilisation of the medial meniscus and cartilage damage

McCulloch, K., Huesa, C., Dunning, L., van't Hof, R., Lockhart, J. & Goodyear, C., 28 Sep 2018.

Research output: Contribution to conferenceAbstract

A combined model of destabilisation of the medial meniscus and cartilage damage accelerates osteophytogenesis in osteoarthritis

McCulloch, K., Huesa, C., Dunning, L., van 't Hof, R., Lockhart, J. & Goodyear, C., 26 Apr 2018, p. 32-32. 1 p.

Research output: Contribution to conferencePoster

A novel dual injury osteoarthritis (OA) model that combines destabilisation of the medial meniscus and cartilage damage leads to accelerated osteophytogenesis

McCulloch, K., Huesa, C., Dunning, L., van't Hof, R., Lockhart, J. & Goodyear, C. S., 23 Feb 2018. 1 p.

Research output: Contribution to conferencePoster

Assessment of the effects of exercise on a murine model of OA

Huesa, C., Dunning, L., Macdougall, K., Ortiz, A., Villaluz, M. M., Fegen, M., Crilly, A., Litherland, G., MacKenzie, A., van't Hof, R., Goodyear, C. & Lockhart, J., 30 Apr 2018, In : Osteoarthritis and Cartilage. 26, Supplement 1, p. s68 1 p.

Research output: Contribution to journalMeeting Abstract

Proteinase activated receptor 2 (PAR2) modulation of airway smooth muscle function

Black, K., MacKenzie, A., Dunning, L., Crilly, A., McGarvey, L., Thornbury, K., Goodyear, C., Lockhart, J. & Litherland, G., 8 Oct 2018, In : Irish Journal of Medical Science. 187, Supplement 8, p. S249-S249 1 p.

Research output: Contribution to journalMeeting Abstract

Open Access
File
21 Downloads (Pure)

Rheumatic disease: protease-activated receptor-2 in synovial joint pathobiology

McCulloch, K., McGrath, S., Huesa, C., Dunning, L., Litherland, G., Crilly, A., Hultin, L., Ferrell, W. R., Lockhart, J. & Goodyear, C., 23 May 2018, In : Frontiers in Endocrinology. 9, 257.

Research output: Contribution to journalReview article

Open Access
1 Citation (Scopus)
2019

Accelerated post traumatic osteoarthritis in a dual injury murine model

McCulloch, K., Huesa, C., Dunning, L., Litherland, G. J., Van't Hof, R. J., Lockhart, J. C. & Goodyear, C. S., 31 Dec 2019, In : Osteoarthritis and Cartilage. 27, 12, p. 1800-1810 11 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
124 Downloads (Pure)

Enhanced airway smooth muscle relaxation via proteinase activated receptor 2

Black, K., MacKenzie, A., Dunning, L., Crilly, A., Brzeszczynska, J., McGarvey, L., Thornbury, K., Goodyear, C. S., Lockhart, J. C. & Litherland, G. J., 22 Nov 2019, In : Irish Journal of Medical Science. 188, SUPPL 10, p. 286-286 1 p.

Research output: Contribution to journalMeeting Abstract

PAR2 accelerates osteoarthritis-like joint changes in a murine model of post-traumatic osteoarthritis

Goodyear, C., McCulloch, K., Huesa, C., Dunning, L., van 't Hof, R. & Lockhart, J., 27 Jun 2019, In : Annals of the Rheumatic Diseases. 78, Issue Suppl 2, p. 110-110 1 p.

Research output: Contribution to journalMeeting Abstract

Open Access

Proteinase activated receptor 2 (PAR2) modulation of murine airway function

Black, K., MacKenzie, A., Dunning, L., Crilly, A., Brzeszczyńska, J., McGarvey, L., Thornbury, K., Goodyear, C. S., Lockhart, J. & Litherland, G., 10 Sep 2019.

Research output: Contribution to conferencePoster

Open Access
File
7 Downloads (Pure)

Proteinase activated receptor 2 modulates expression of autophagy markers in murine lungs

McCallum, K., Dunning, L., McGarvey, L., Hollywood, M., Goodyear, C. S., Brzeszczynska, J., Crilly, A., Lockhart, J. C. & Litherland, G. J., 22 Nov 2019, In : Irish Journal of Medical Science. 188, SUPPL 10, p. S270-S270 1 p., 2.6.

Research output: Contribution to journalMeeting Abstract

Understanding PAR2 matriptase ENaC crosstalk in the lung: implications for COPD

Bailo, M., Dunning, L., Brzeszczynska, J., Martin, S. L., Sergeant, G. P., Goodyear, C. S., Litherland, G. J., Lockhart, J. C. & Crilly, A., 30 Nov 2019, In : Irish Journal of Medical Science. 188, SUPPL 10, p. 268-269 2 p.

Research output: Contribution to journalMeeting Abstract