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Lynette Dunning

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Research Output 2003 2019

2019
70 Downloads (Pure)

Accelerated post traumatic osteoarthritis in a dual injury murine model

McCulloch, K., Huesa, C., Dunning, L., Litherland, G. J., Van't Hof, R. J., Lockhart, J. C. & Goodyear, C. S., 5 Jul 2019, In : Osteoarthritis and Cartilage.

Research output: Contribution to journalArticle

Open Access
File
Cartilage
Osteoarthritis
Wounds and Injuries
Ligaments
Osteophyte

PAR2 accelerates osteoarthritis-like joint changes in a murine model of post-traumatic osteoarthritis

Goodyear, C., McCulloch, K., Huesa, C., Dunning, L., van 't Hof, R. & Lockhart, J., 27 Jun 2019, In : Annals of the Rheumatic Diseases. 78, Issue Suppl 2, p. 110-110 1 p.

Research output: Contribution to journalMeeting Abstract

Open Access
PAR-2 Receptor
Osteoarthritis
Joints
Cartilage
Tibial Meniscus
2018
Tibial Meniscus
Cartilage
Wounds and Injuries
Osteoarthritis
Osteophyte

A combined model of destabilisation of the medial meniscus and cartilage damage accelerates osteophytogenesis in osteoarthritis

McCulloch, K., Huesa, C., Dunning, L., van 't Hof, R., Lockhart, J. & Goodyear, C., 26 Apr 2018, p. 32-32. 1 p.

Research output: Contribution to conferencePoster

Tibial Meniscus
Osteoarthritis
Cartilage
Osteophyte
Bone and Bones
Tibial Meniscus
Osteoarthritis
Cartilage
Wounds and Injuries
Osteophyte

Assessment of the effects of exercise on a murine model of OA

Huesa, C., Dunning, L., Macdougall, K., Ortiz, A., Villaluz, M. M., Fegen, M., Crilly, A., Litherland, G., MacKenzie, A., van't Hof, R., Goodyear, C. & Lockhart, J., 8 Jan 2018, (Accepted/In press).

Research output: Contribution to conferencePoster

Tibial Meniscus
Osteoarthritis
Exercise
Joints
Osteosclerosis

Rheumatic disease: protease-activated receptor-2 in synovial joint pathobiology

McCulloch, K., McGrath, S., Huesa, C., Dunning, L., Litherland, G., Crilly, A., Hultin, L., Ferrell, W. R., Lockhart, J. & Goodyear, C., 23 May 2018, In : Frontiers in Endocrinology. 9, 257.

Research output: Contribution to journalReview article

Open Access
PAR-2 Receptor
Rheumatic Diseases
Joints
Osteoarthritis
Cartilage
2017
68 Downloads (Pure)
Open Access
File
Angiotensin Type 1 Receptor
Freund's Adjuvant
Endothelium
Rheumatoid Arthritis
Losartan
2016

Proteinase-activated Receptor 2: Potential Role in Osteoarthritic Entheseal Pathology

Ortiz, A., Dunning, L., Huesa, C., Ferrell, W. R., McInnes, I. B., Lockhart, J., Millar, N. L., Goodyear, C. S. & Crilly, A., 27 Oct 2016, In : Orthopaedic Proceedings. 98-B, Suppl. 16

Research output: Contribution to journalMeeting Abstract

Open Access

Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology

Huesa, C., Ortiz, A. C., Dunning, L., McGavin, L., Bennett, L., McIntosh, K., Crilly, A., Kurowska-Stolarska, M., Plevin, R., van 't Hof, R. J., Rowan, A. D., McInnes, I. B., Goodyear, C. S., Lockhart, J. C. & Ferrell, W. R., 2016, In : Annals of the Rheumatic Diseases. 75, 11, p. 1989-1997

Research output: Contribution to journalArticle

Open Access
PAR-2 Receptor
Cartilage
Pathology
Osteoarthritis
Bone
2015

Differential Inflammatory Profile in Experimental Models of Arthritis

Ortiz, A. C., Crilly, A., Dunning, L., Huesa, C., Goodyear, C. S., Lockhart, J. C., Ferrell, W. R. & McInnes, I. B., Oct 2015, In : Arthritis & Rheumatology. 67, 1139.

Research output: Contribution to journalMeeting Abstract

Open Access

Microrna Biomarker Signature in Osteoarthritis

Bennett, L. A., Coleman, T., Ferrell, W., Lockhart, J., Huesa, C., Dunning, L., Jones, B., Blyth, M., McInnes, I. B., Kurowska-Stolarska, M. & Goodyear, C. S., Oct 2015, In : Arthritis & Rheumatology. 67, 2398.

Research output: Contribution to journalMeeting Abstract

Open Access
2012

Correlation of protease-activated receptor-2 expression and synovitis in rheumatoid and osteoarthritis

Tindell, A. G., Kelso, E. B., Ferrell, W. R., Lockhart, J. C., Walsh, D. A., Dunning, L. & McInnes, I. B., Oct 2012, In : Rheumatology International. 32, 10, p. 3077-86 10 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
Synovitis
Osteoarthritis
Synovial Fluid
Monocytes

Immunomodulatory role of proteinase-activated receptor-2

Crilly, A., Palmer, H., Nickdel, M. B., Dunning, L., Lockhart, J. C., Plevin, R., Mcinnes, I. B. & Ferrell, W. R., May 2012, In : Annals of the Rheumatic Diseases. 71, 9, p. 1559-1566 8 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
Experimental Arthritis
Collagen
Arthritis
Joints

PAR(2) expression in peripheral blood monocytes of patients with rheumatoid arthritis

Crilly, A., Burns, E., Nickdel, M. B., Lockhart, J. C., Perry, M. E., Ferrell, P. W., Baxter, D., Dale, J., Dunning, L., Wilson, H., Nijjar, J. S., Gracie, J. A., Ferrell, W. R. & McInnes, I. B., Jun 2012, In : Annals of the Rheumatic Diseases. 71, 6, p. 1049-1054

Research output: Contribution to journalArticle

2009

A model of chronic monoarthritis impairs EDHF but not NO activity in the saphenous artery of the rat

MacKenzie, A., Dunning, L., Ferrell, W. R. & Lockhart, J., Dec 2009, Proceedings of the British Pharmacological Society at http://www.pA2online.org/abstracts/Vol7Issue4abst004P.pdf . British Pharmacological Society, (pA2 Online; vol. 7, no. 4).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
Experimental Arthritis
Freund's Adjuvant
Arthritis
Knee
Endothelial Cells
2007

Expression and pro-inflammatory role of proteinase-activated receptor 2 in rheumatoid synovium: ex vivo studies suing a novel proteinase-activated receptor-2 antagonist.

Kelso, E. B., Ferrell, W. R., Lockhart, J., Elias-Jones, I., Hembrough, T., Dunning, L., Gracie, J. A. & McInness, I. B., 2007, In : Arthritis & Rheumatology. 56, 3, p. 765-771 7 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
Synovial Membrane
Rheumatoid Arthritis
Arthritis
Cytokines
2006

Therapeutic promise of proteinase-activated receptor-2 antagonism in joint inflammation

Kelso, E. B., Lockhart, J. C., Hembrough, T., Dunning, L., Plevin, R., Hollenberg, M. D., Sommerhoff, C. P., McLean, J. S. & Ferrell, W. R., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316, 3, p. 1017-1024 8 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
Joints
Inflammation
Kaolin
Carrageenan
2003

Essential role for proteinase activated receptor-2 in arthritis

Ferrell, W. R., Lockhart, J. C., Kelso, E. B., Dunning, L., Plevin, R., Meek, S. E., Smith, A. J. H., Hunter, G. D., McLean, J. S., McGarry, F., Ramage, R., Jiang, L., Kanke, T. & Kawagoe, J., 2003, In : The Journal of Clinical Investigation. 111, p. 35-41 7 p.

Research output: Contribution to journalArticle

Open Access
PAR-2 Receptor
Arthritis
Inflammation
Joints
Intra-Articular Injections