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Lynette Dunning

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Research Output 2003 2019

2019
90 Downloads (Pure)

Accelerated post traumatic osteoarthritis in a dual injury murine model

McCulloch, K., Huesa, C., Dunning, L., Litherland, G. J., Van't Hof, R. J., Lockhart, J. C. & Goodyear, C. S., 31 Dec 2019, In : Osteoarthritis and Cartilage. 27, 12, p. 1800-1810 11 p.

Research output: Contribution to journalArticle

Open Access
File
Cartilage
Osteoarthritis
Wounds and Injuries
Ligaments
Osteophyte

Enhanced airway smooth muscle relaxation via proteinase activated receptor 2

Black, K., MacKenzie, A., Dunning, L., Crilly, A., Brzeszczynska, J., McGarvey, L., Thornbury, K., Goodyear, C. S., Lockhart, J. C. & Litherland, G. J., 22 Nov 2019, In : Irish Journal of Medical Science. 188, SUPPL 10, p. 286-286 1 p.

Research output: Contribution to journalMeeting Abstract

PAR2 accelerates osteoarthritis-like joint changes in a murine model of post-traumatic osteoarthritis

Goodyear, C., McCulloch, K., Huesa, C., Dunning, L., van 't Hof, R. & Lockhart, J., 27 Jun 2019, In : Annals of the Rheumatic Diseases. 78, Issue Suppl 2, p. 110-110 1 p.

Research output: Contribution to journalMeeting Abstract

Open Access
PAR-2 Receptor
Osteoarthritis
Joints
Cartilage
Tibial Meniscus

Proteinase activated receptor 2 (PAR2) modulation of murine airway function

Black, K., MacKenzie, A., Dunning, L., Crilly, A., Brzeszczyńska, J., McGarvey, L., Thornbury, K., Goodyear, C. S., Lockhart, J. & Litherland, G., 10 Sep 2019.

Research output: Contribution to conferencePoster

Open Access
File
PAR-2 Receptor
Smooth Muscle
Trypsin
Chronic Obstructive Pulmonary Disease
Oxidative Stress

Proteinase activated receptor 2 modulates expression of autophagy markers in murine lungs

McCallum, K., Dunning, L., McGarvey, L., Hollywood, M., Goodyear, C. S., Brzeszczynska, J., Crilly, A., Lockhart, J. C. & Litherland, G. J., 22 Nov 2019, In : Irish Journal of Medical Science. 188, SUPPL 10, p. S270-S270 1 p., 2.6.

Research output: Contribution to journalMeeting Abstract

2018

Accelerated osteoarthritic-like symptoms in a novel dual injury model combining destabilisation of the medial meniscus and cartilage damage

McCulloch, K., Huesa, C., Dunning, L., van't Hof, R., Lockhart, J. & Goodyear, C., 28 Sep 2018.

Research output: Contribution to conferenceAbstract

Tibial Meniscus
Cartilage
Wounds and Injuries
Osteoarthritis
Osteophyte

A combined model of destabilisation of the medial meniscus and cartilage damage accelerates osteophytogenesis in osteoarthritis

McCulloch, K., Huesa, C., Dunning, L., van 't Hof, R., Lockhart, J. & Goodyear, C., 26 Apr 2018, p. 32-32. 1 p.

Research output: Contribution to conferencePoster

Tibial Meniscus
Osteoarthritis
Cartilage
Osteophyte
Bone and Bones

A novel dual injury osteoarthritis (OA) model that combines destabilisation of the medial meniscus and cartilage damage leads to accelerated osteophytogenesis

McCulloch, K., Huesa, C., Dunning, L., van't Hof, R., Lockhart, J. & Goodyear, C. S., 23 Feb 2018. 1 p.

Research output: Contribution to conferencePoster

Tibial Meniscus
Osteoarthritis
Cartilage
Wounds and Injuries
Osteophyte

Assessment of the effects of exercise on a murine model of OA

Huesa, C., Dunning, L., Macdougall, K., Ortiz, A., Villaluz, M. M., Fegen, M., Crilly, A., Litherland, G., MacKenzie, A., van't Hof, R., Goodyear, C. & Lockhart, J., 8 Jan 2018, (Accepted/In press).

Research output: Contribution to conferencePoster

Tibial Meniscus
Osteoarthritis
Exercise
Joints
Osteosclerosis

Proteinase activated receptor 2 (PAR2) modulation of airway smooth muscle function

Black, K., MacKenzie, A., Dunning, L., Crilly, A., McGarvey, L., Thornbury, K., Goodyear, C., Lockhart, J. & Litherland, G., 8 Oct 2018, In : Irish Journal of Medical Science. 187, Supplement 8, p. S249-S249 1 p.

Research output: Contribution to journalMeeting Abstract

Open Access
File
PAR-2 Receptor
Smooth Muscle
Chronic Obstructive Pulmonary Disease
Lung
Muscle Tonus
1 Citation (Scopus)

Rheumatic disease: protease-activated receptor-2 in synovial joint pathobiology

McCulloch, K., McGrath, S., Huesa, C., Dunning, L., Litherland, G., Crilly, A., Hultin, L., Ferrell, W. R., Lockhart, J. & Goodyear, C., 23 May 2018, In : Frontiers in Endocrinology. 9, 257.

Research output: Contribution to journalReview article

Open Access
PAR-2 Receptor
Rheumatic Diseases
Joints
Osteoarthritis
Cartilage
2017
2 Citations (Scopus)
87 Downloads (Pure)
Open Access
File
Angiotensin Type 1 Receptor
Freund's Adjuvant
Endothelium
Rheumatoid Arthritis
Losartan
2016

Proteinase-activated Receptor 2: Potential Role in Osteoarthritic Entheseal Pathology

Ortiz, A., Dunning, L., Huesa, C., Ferrell, W. R., McInnes, I. B., Lockhart, J., Millar, N. L., Goodyear, C. S. & Crilly, A., 27 Oct 2016, In : Orthopaedic Proceedings. 98-B, Suppl. 16

Research output: Contribution to journalMeeting Abstract

Open Access
20 Citations (Scopus)

Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology

Huesa, C., Ortiz, A. C., Dunning, L., McGavin, L., Bennett, L., McIntosh, K., Crilly, A., Kurowska-Stolarska, M., Plevin, R., van 't Hof, R. J., Rowan, A. D., McInnes, I. B., Goodyear, C. S., Lockhart, J. C. & Ferrell, W. R., 2016, In : Annals of the Rheumatic Diseases. 75, 11, p. 1989-1997

Research output: Contribution to journalArticle

Open Access
PAR-2 Receptor
Cartilage
Pathology
Osteoarthritis
Bone
2015

Differential Inflammatory Profile in Experimental Models of Arthritis

Ortiz, A. C., Crilly, A., Dunning, L., Huesa, C., Goodyear, C. S., Lockhart, J. C., Ferrell, W. R. & McInnes, I. B., Oct 2015, In : Arthritis & Rheumatology. 67, 1139.

Research output: Contribution to journalMeeting Abstract

Open Access

Microrna Biomarker Signature in Osteoarthritis

Bennett, L. A., Coleman, T., Ferrell, W., Lockhart, J., Huesa, C., Dunning, L., Jones, B., Blyth, M., McInnes, I. B., Kurowska-Stolarska, M. & Goodyear, C. S., Oct 2015, In : Arthritis & Rheumatology. 67, 2398.

Research output: Contribution to journalMeeting Abstract

Open Access
2013
8 Citations (Scopus)
2012
8 Citations (Scopus)

Correlation of protease-activated receptor-2 expression and synovitis in rheumatoid and osteoarthritis

Tindell, A. G., Kelso, E. B., Ferrell, W. R., Lockhart, J. C., Walsh, D. A., Dunning, L. & McInnes, I. B., Oct 2012, In : Rheumatology International. 32, 10, p. 3077-86 10 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
Synovitis
Osteoarthritis
Synovial Fluid
Monocytes
12 Citations (Scopus)

Immunomodulatory role of proteinase-activated receptor-2

Crilly, A., Palmer, H., Nickdel, M. B., Dunning, L., Lockhart, J. C., Plevin, R., Mcinnes, I. B. & Ferrell, W. R., May 2012, In : Annals of the Rheumatic Diseases. 71, 9, p. 1559-1566 8 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
Experimental Arthritis
Collagen
Arthritis
Joints
12 Citations (Scopus)

PAR(2) expression in peripheral blood monocytes of patients with rheumatoid arthritis

Crilly, A., Burns, E., Nickdel, M. B., Lockhart, J. C., Perry, M. E., Ferrell, P. W., Baxter, D., Dale, J., Dunning, L., Wilson, H., Nijjar, J. S., Gracie, J. A., Ferrell, W. R. & McInnes, I. B., Jun 2012, In : Annals of the Rheumatic Diseases. 71, 6, p. 1049-1054

Research output: Contribution to journalArticle

2009

A model of chronic monoarthritis impairs EDHF but not NO activity in the saphenous artery of the rat

MacKenzie, A., Dunning, L., Ferrell, W. R. & Lockhart, J., Dec 2009, Proceedings of the British Pharmacological Society at http://www.pA2online.org/abstracts/Vol7Issue4abst004P.pdf . British Pharmacological Society, (pA2 Online; vol. 7, no. 4).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
Experimental Arthritis
Freund's Adjuvant
Arthritis
Knee
Endothelial Cells
2007
52 Citations (Scopus)

Expression and pro-inflammatory role of proteinase-activated receptor 2 in rheumatoid synovium: ex vivo studies suing a novel proteinase-activated receptor-2 antagonist.

Kelso, E. B., Ferrell, W. R., Lockhart, J., Elias-Jones, I., Hembrough, T., Dunning, L., Gracie, J. A. & McInness, I. B., 2007, In : Arthritis & Rheumatology. 56, 3, p. 765-771 7 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
Synovial Membrane
Rheumatoid Arthritis
Arthritis
Cytokines
2006
150 Citations (Scopus)

Therapeutic promise of proteinase-activated receptor-2 antagonism in joint inflammation

Kelso, E. B., Lockhart, J. C., Hembrough, T., Dunning, L., Plevin, R., Hollenberg, M. D., Sommerhoff, C. P., McLean, J. S. & Ferrell, W. R., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316, 3, p. 1017-1024 8 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
Joints
Inflammation
Kaolin
Carrageenan
2003
270 Citations (Scopus)

Essential role for proteinase activated receptor-2 in arthritis

Ferrell, W. R., Lockhart, J. C., Kelso, E. B., Dunning, L., Plevin, R., Meek, S. E., Smith, A. J. H., Hunter, G. D., McLean, J. S., McGarry, F., Ramage, R., Jiang, L., Kanke, T. & Kawagoe, J., 2003, In : The Journal of Clinical Investigation. 111, p. 35-41 7 p.

Research output: Contribution to journalArticle

Open Access
PAR-2 Receptor
Arthritis
Inflammation
Joints
Intra-Articular Injections