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Article
2019

Accelerated post traumatic osteoarthritis in a dual injury murine model

McCulloch, K., Huesa, C., Dunning, L., Litherland, G. J., Van't Hof, R. J., Lockhart, J. C. & Goodyear, C. S., 31 Dec 2019, In : Osteoarthritis and Cartilage. 27, 12, p. 1800-1810 11 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
116 Downloads (Pure)
2017
Open Access
File
2 Citations (Scopus)
111 Downloads (Pure)

The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover

Wilkinson, D. J., Desilets, A., Lin, H., Charlton, S., del Carmen Arques, M., Falconer, A., Bullock, C., Hsu, Y-C., Birchall, K., Hawkins, A., Thompson, P., Ferrell, W. R., Lockhart, J., Plevin, R., Zhang, Y., Blain, E., Lin, S-W., Leduc, R., Milner, J. M. & Rowan, A. D., 1 Dec 2017, In : Scientific Reports. 7, p. 1-38 38 p., 16693.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
107 Downloads (Pure)
2016

Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology

Huesa, C., Ortiz, A. C., Dunning, L., McGavin, L., Bennett, L., McIntosh, K., Crilly, A., Kurowska-Stolarska, M., Plevin, R., van 't Hof, R. J., Rowan, A. D., McInnes, I. B., Goodyear, C. S., Lockhart, J. C. & Ferrell, W. R., 11 Oct 2016, In : Annals of the Rheumatic Diseases. 75, 11, p. 1989-1997

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)
2013
8 Citations (Scopus)

Proteinase-activated receptor-2 modulates human macrophage differentiation and effector function

Steven, R., Crilly, A., Lockhart, J. C., R. Ferrell, W. & McInnes, I. B., Dec 2013, In : Innate Immunity. 19, 6, p. 663-72 10 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)
2012

Correlation of protease-activated receptor-2 expression and synovitis in rheumatoid and osteoarthritis

Tindell, A. G., Kelso, E. B., Ferrell, W. R., Lockhart, J. C., Walsh, D. A., Dunning, L. & McInnes, I. B., Oct 2012, In : Rheumatology International. 32, 10, p. 3077-86 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Immunomodulatory role of proteinase-activated receptor-2

Crilly, A., Palmer, H., Nickdel, M. B., Dunning, L., Lockhart, J. C., Plevin, R., Mcinnes, I. B. & Ferrell, W. R., May 2012, In : Annals of the Rheumatic Diseases. 71, 9, p. 1559-1566 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

PAR(2) expression in peripheral blood monocytes of patients with rheumatoid arthritis

Crilly, A., Burns, E., Nickdel, M. B., Lockhart, J. C., Perry, M. E., Ferrell, P. W., Baxter, D., Dale, J., Dunning, L., Wilson, H., Nijjar, J. S., Gracie, J. A., Ferrell, W. R. & McInnes, I. B., Jun 2012, In : Annals of the Rheumatic Diseases. 71, 6, p. 1049-1054

Research output: Contribution to journalArticle

12 Citations (Scopus)
2010

Matriptase Is a Novel Initiator of Cartilage Matrix Degradation in Osteoarthritis

Milner, J. M., Patel, A., Davidson, R. K., Swingler, T. E., Desilets, A., Young, D. A., Kelso, E. B., Donell, S. T., Cawston, T. E., Clark, I. M., Ferrell, W. R., Plevin, R., Lockhart, J. C., Leduc, R. & Rowan, A. D., Jul 2010, In : Arthritis and Rheumatism. 62, 7, p. 1955-1966

Research output: Contribution to journalArticle

56 Citations (Scopus)

Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis

Ferrell, W. R., Kelso, E. B., Lockhart, J. C., Plevin, R. & McInnes, I. B., Nov 2010, In : Annals of the Rheumatic Diseases. 69, 11, p. 2051-2054

Research output: Contribution to journalArticle

29 Citations (Scopus)

Proteinase-activated receptor-2 mediated inhibition of TNF alpha-stimulated JNK activation: A novel paradigm for G(q/11) linked GPCRs

McIntosh, K., Cunningham, M. R., Cadalbert, L., Lockhart, J., Boyd, G., Ferrell, W. R. & Plevin, R., Feb 2010, In : Cellular Signalling. 22, 2, p. 265-273

Research output: Contribution to journalArticle

7 Citations (Scopus)
2008

Protease-activated receptor-2 (PAR-2): A potential new target in arthritis

R. Ferrell, W., Lockhart, J. & Plevin, R., 2008, In : Drugs of the Future. 33, 3, p. 241-248

Research output: Contribution to journalArticle

2 Citations (Scopus)
2007

Angiotensin II type 1 receptor as a novel therapeutic target in rheumatoid arthritis: In vivo analyses in rodent models of arthritis and ex vivo analyses in human inflammatory synovitis

Price, A., Lockhart, J., Ferrell, W. R., Gsell, W., McLean, S. & Sturrock, R. D., 2007, In : Arthritis & Rheumatology. 56, 2, p. 441-447 7 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Expression and pro-inflammatory role of proteinase-activated receptor 2 in rheumatoid synovium: ex vivo studies suing a novel proteinase-activated receptor-2 antagonist.

Kelso, E. B., Ferrell, W. R., Lockhart, J., Elias-Jones, I., Hembrough, T., Dunning, L., Gracie, J. A. & McInness, I. B., 2007, In : Arthritis & Rheumatology. 56, 3, p. 765-771 7 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Proteinase-activated receptor-2 (PAR2) mediates the pro-inflammatory effects of synovial mast cells.

Palmer, H. S., Kelso, E. B., Lockhart, J. C., Sommerhoff, C. P., Plevin, R., Goh, F. G. & Ferrell, W. R., 2007, In : Arthritis & Rheumatology. 56, 11, p. 3532-3540 9 p.

Research output: Contribution to journalArticle

2006

Therapeutic promise of proteinase-activated receptor-2 antagonism in joint inflammation

Kelso, E. B., Lockhart, J. C., Hembrough, T., Dunning, L., Plevin, R., Hollenberg, M. D., Sommerhoff, C. P., McLean, J. S. & Ferrell, W. R., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316, 3, p. 1017-1024 8 p.

Research output: Contribution to journalArticle

151 Citations (Scopus)
2005

Protective effect of sensory denervation in inflammatory arthritis (evidence of regulatory neuroimmune pathways in the arthritic joint)

Kane, D., Lockhart, J. C., Balint, P. V., Mann, C., Ferrell, W. R. & McInnes, I. B., 2005, In : Annals of the Rheumatic Diseases. 64, 2, p. 325-327 3 p.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)
2004

Divergent roles of nitrergic and prostanoid pathways in chronic joint inflammation.

Day, S. M., Lockhart, J. C., Ferrell, W. R. & McLean, J. S., 2004, In : Annals of the Rheumatic Diseases. 63, 12, p. 1564-1570 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Pathophysiology of vascular dysfunction in a rat model of chronic joint inflammation.

Egan, C. G., Lockhart, J. C. & Ferrell, W. R., 2004, In : The Journal of Physiology. 557, 2, p. 635-643 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2003

Combined inhibition of nitrergic and prostanoid pathways in J774 macrophages

Day, S. M., McLean, J. S., Lockhart, J. C. & Ferrell, W. R., 2003, In : Clinical Experimental Rheumatology. 21, p. 625-631 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Essential role for proteinase activated receptor-2 in arthritis

Ferrell, W. R., Lockhart, J. C., Kelso, E. B., Dunning, L., Plevin, R., Meek, S. E., Smith, A. J. H., Hunter, G. D., McLean, J. S., McGarry, F., Ramage, R., Jiang, L., Kanke, T. & Kawagoe, J., 2003, In : The Journal of Clinical Investigation. 111, p. 35-41 7 p.

Research output: Contribution to journalArticle

Open Access
272 Citations (Scopus)
2002

Pathophysiological basis of acute inflammatory hyperaemia in the rat knee joint: role of cyclooxygenase-1 and -2.

Egan, C. G., Lockhart, J., Ferrell, W. R., Day, S. M. & McLean, J. S., 2002, In : Journal of Physiology. 539, 2, p. 579-587 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2001

Expression of constitutive but not inducible cyclooxygenase maintains synovial perfusion in the rat knee.

Egan, CG., Lockhart, JC., McLean, JS. & Ferrell, WR., Mar 2001, In : Experimental Physiology. 86, 2, p. 191-197 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Metacarpophalangeal joints in rheumatoid arthritis: laser doppler imaging—initial experience

Ferrell, W. R., Balint, P. V., Egan, CG., Lockhart, J. & Sturrock, R. D., 1 Jul 2001, In : Radiology. 220, 1, p. 257-262

Research output: Contribution to journalArticle

23 Citations (Scopus)