20012020

Research output per year

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Research Output

2020

Exosomes in intercellular communication and implications for osteoarthritis

Asghar, S., Litherland, G. J., Lockhart, J. C., Goodyear, C. S. & Crilly, A., 1 Jan 2020, In : Rheumatology. 59, 1, p. 57-68 12 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)
2019

Accelerated post traumatic osteoarthritis in a dual injury murine model

McCulloch, K., Huesa, C., Dunning, L., Litherland, G. J., Van't Hof, R. J., Lockhart, J. C. & Goodyear, C. S., 31 Dec 2019, In : Osteoarthritis and Cartilage. 27, 12, p. 1800-1810 11 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
116 Downloads (Pure)

Differential effects of exosomes derived from separate osteoarthritis synovial compartments: implications for erosive cartilage disease

Asghar, S., Litherland, G., Meek, D., Cole, J., Lockhart, J., Goodyear, C. S. & Crilly, A., 30 Apr 2019, In : Osteoarthritis and Cartilage. 27, S1, p. S192 1 p., 260.

Research output: Contribution to journalMeeting Abstract

1 Citation (Scopus)

Enhanced airway smooth muscle relaxation via proteinase activated receptor 2

Black, K., MacKenzie, A., Dunning, L., Crilly, A., Brzeszczynska, J., McGarvey, L., Thornbury, K., Goodyear, C. S., Lockhart, J. C. & Litherland, G. J., 22 Nov 2019, In : Irish Journal of Medical Science. 188, SUPPL 10, p. 286-286 1 p.

Research output: Contribution to journalMeeting Abstract

Evaluation of novel serine protease inhibitors to ameliorate cockroach-induced airway inflammation and cell damage

Reihill, J., Yang, Z., Carroll, E., McGarvey, L., Lundy, F., Lockhart, J., Sergeant, G. & Martin, L., 6 Apr 2019.

Research output: Contribution to conferenceAbstract

Inhibition of ENaC activity by novel peptide trypsin-like inhibitors derived from amphibian skin secretions

Carroll, E., Chen, T., Douglas, L., Hollywood, M., Lockhart, J., Martin, S. L., Lundy, F., McGarvey, L., Reihill, J. & Zhou, M., 6 Apr 2019.

Research output: Contribution to conferenceAbstract

PAR2 accelerates osteoarthritis-like joint changes in a murine model of post-traumatic osteoarthritis

Goodyear, C., McCulloch, K., Huesa, C., Dunning, L., van 't Hof, R. & Lockhart, J., 27 Jun 2019, In : Annals of the Rheumatic Diseases. 78, Issue Suppl 2, p. 110-110 1 p.

Research output: Contribution to journalMeeting Abstract

Open Access

Proteinase activated receptor 2 (PAR2) modulation of murine airway function

Black, K., MacKenzie, A., Dunning, L., Crilly, A., Brzeszczyńska, J., McGarvey, L., Thornbury, K., Goodyear, C. S., Lockhart, J. & Litherland, G., 10 Sep 2019.

Research output: Contribution to conferencePoster

Open Access
File
2 Downloads (Pure)

Proteinase activated receptor 2 modulates expression of autophagy markers in murine lungs

McCallum, K., Dunning, L., McGarvey, L., Hollywood, M., Goodyear, C. S., Brzeszczynska, J., Crilly, A., Lockhart, J. C. & Litherland, G. J., 22 Nov 2019, In : Irish Journal of Medical Science. 188, SUPPL 10, p. S270-S270 1 p., 2.6.

Research output: Contribution to journalMeeting Abstract

Understanding PAR2 matriptase ENaC crosstalk in the lung: implications for COPD

Bailo, M., Dunning, L., Brzeszczynska, J., Martin, S. L., Sergeant, G. P., Goodyear, C. S., Litherland, G. J., Lockhart, J. C. & Crilly, A., 30 Nov 2019, In : Irish Journal of Medical Science. 188, SUPPL 10, p. 268-269 2 p.

Research output: Contribution to journalMeeting Abstract

2018

Accelerated osteoarthritic-like symptoms in a novel dual injury model combining destabilisation of the medial meniscus and cartilage damage

McCulloch, K., Huesa, C., Dunning, L., van't Hof, R., Lockhart, J. & Goodyear, C., 28 Sep 2018.

Research output: Contribution to conferenceAbstract

A combined model of destabilisation of the medial meniscus and cartilage damage accelerates osteophytogenesis in osteoarthritis

McCulloch, K., Huesa, C., Dunning, L., van 't Hof, R., Lockhart, J. & Goodyear, C., 26 Apr 2018, p. 32-32. 1 p.

Research output: Contribution to conferencePoster

A novel dual injury osteoarthritis (OA) model that combines destabilisation of the medial meniscus and cartilage damage leads to accelerated osteophytogenesis

McCulloch, K., Huesa, C., Dunning, L., van't Hof, R., Lockhart, J. & Goodyear, C. S., 23 Feb 2018. 1 p.

Research output: Contribution to conferencePoster

Assessment of the effects of exercise on a murine model of OA

Huesa, C., Dunning, L., Macdougall, K., Ortiz, A., Villaluz, M. M., Fegen, M., Crilly, A., Litherland, G., MacKenzie, A., van't Hof, R., Goodyear, C. & Lockhart, J., 30 Apr 2018, In : Osteoarthritis and Cartilage. 26, Supplement 1, p. s68 1 p.

Research output: Contribution to journalMeeting Abstract

Inhibition of ENaC activity by novel peptide trypsin-like inhibitors derived from amphibian skin secretions

Carroll, E. L., Douglas, L. E. J., Reihill, J. A., Zhou, M., Chen, T., McGarvey, L. P., Lundy, F. T., Hollywood, M. A., Crilly, A., Lockhart, J. C. & Martin, S. L., Aug 2018, In : Irish Journal of Medical Science. 187, Supplement 8, p. S250-S251 2 p.

Research output: Contribution to journalMeeting Abstract

Isolation and characterisation of exosomes from human primary bronchial epithelial cells

Lockhart, J., Downey, N., McGarvey, L., Martin, L., Crilly, A., Reihill, J. & Lundy, F., 2018, In : Irish Journal of Medical Science. 187, Supplement 8, p. S252-S252 1 p.

Research output: Contribution to journalMeeting Abstract

Protease activated receptor 2 (PAR2) expression in the myeloid compartment impacts osteoclastogenesis

Lockhart, J., McGrath, S., Hultin, L. & Goodyear, C., 21 Feb 2018, In : Annals of the Rheumatic Diseases. 77, Supplement 1, p. A21 1 p., P018.

Research output: Contribution to journalMeeting Abstract

35 Citations (Scopus)

Proteinase activated receptor 2 (PAR2) modulation of airway smooth muscle function

Black, K., MacKenzie, A., Dunning, L., Crilly, A., McGarvey, L., Thornbury, K., Goodyear, C., Lockhart, J. & Litherland, G., 8 Oct 2018, In : Irish Journal of Medical Science. 187, Supplement 8, p. S249-S249 1 p.

Research output: Contribution to journalMeeting Abstract

Open Access
File
14 Downloads (Pure)

Rheumatic disease: protease-activated receptor-2 in synovial joint pathobiology

McCulloch, K., McGrath, S., Huesa, C., Dunning, L., Litherland, G., Crilly, A., Hultin, L., Ferrell, W. R., Lockhart, J. & Goodyear, C., 23 May 2018, In : Frontiers in Endocrinology. 9, 257.

Research output: Contribution to journalReview article

Open Access
1 Citation (Scopus)

The synovial secretome contributes to cartilage pathology in osteoarthritis: a role for exosomes

Asghar, S., Litherland, G., Meek, D., Goodyear, C., Lockhart, J. & Crilly, A., 30 Apr 2018, In : Osteoarthritis and Cartilage. 26, Supplement 1, p. s131-s132 2 p., 248.

Research output: Contribution to journalMeeting Abstract

2017
Open Access
File
2 Citations (Scopus)
111 Downloads (Pure)

The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover

Wilkinson, D. J., Desilets, A., Lin, H., Charlton, S., del Carmen Arques, M., Falconer, A., Bullock, C., Hsu, Y-C., Birchall, K., Hawkins, A., Thompson, P., Ferrell, W. R., Lockhart, J., Plevin, R., Zhang, Y., Blain, E., Lin, S-W., Leduc, R., Milner, J. M. & Rowan, A. D., 1 Dec 2017, In : Scientific Reports. 7, p. 1-38 38 p., 16693.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
107 Downloads (Pure)

The synovial secretome contributes to cartilage pathology in osteoarthritis (OA): an Exosome Study

Asghar, S., Litherland, G., Meek, D., Goodyear, C., Lockhart, J. & Crilly, A., 5 Dec 2017, (Accepted/In press).

Research output: Contribution to conferencePoster

2016

Evaluating the impact of protease activated receptor 2 (PAR2) gene disruption on T regulatory cell biology

Crilly, A., Cochrane, D., Plevin, R., Ferrell, W. R., McInness, I. B., Goodyear, C. & Lockhart, J., 8 Dec 2016.

Research output: Contribution to conferencePoster

Open Access

Proteinase-activated Receptor 2: Potential Role in Osteoarthritic Entheseal Pathology

Ortiz, A., Dunning, L., Huesa, C., Ferrell, W. R., McInnes, I. B., Lockhart, J., Millar, N. L., Goodyear, C. S. & Crilly, A., 27 Oct 2016, In : Orthopaedic Proceedings. 98-B, Suppl. 16

Research output: Contribution to journalMeeting Abstract

Open Access

Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology

Huesa, C., Ortiz, A. C., Dunning, L., McGavin, L., Bennett, L., McIntosh, K., Crilly, A., Kurowska-Stolarska, M., Plevin, R., van 't Hof, R. J., Rowan, A. D., McInnes, I. B., Goodyear, C. S., Lockhart, J. C. & Ferrell, W. R., 11 Oct 2016, In : Annals of the Rheumatic Diseases. 75, 11, p. 1989-1997

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)
2015

Differential Inflammatory Profile in Experimental Models of Arthritis

Ortiz, A. C., Crilly, A., Dunning, L., Huesa, C., Goodyear, C. S., Lockhart, J. C., Ferrell, W. R. & McInnes, I. B., Oct 2015, In : Arthritis & Rheumatology. 67, 1139.

Research output: Contribution to journalMeeting Abstract

Open Access

Microrna Biomarker Signature in Osteoarthritis

Bennett, L. A., Coleman, T., Ferrell, W., Lockhart, J., Huesa, C., Dunning, L., Jones, B., Blyth, M., McInnes, I. B., Kurowska-Stolarska, M. & Goodyear, C. S., Oct 2015, In : Arthritis & Rheumatology. 67, 2398.

Research output: Contribution to journalMeeting Abstract

Open Access

PAR2 response in fluid flow-stimulated chondrocytes

Huesa, C., Williamson, E., Kreuser, U., Litherland, G., Lockhart, J. & Ferrell, W. R., 1 Sep 2015, p. 36. 1 p.

Research output: Contribution to conferenceAbstract

Open Access
File
49 Downloads (Pure)
2014

Bone changes preceed cartilage degradation in experimental osteoarthritis

Huesa, C., McGavin, L., Habgood, A., Lockhart, J. C., van 't Hof, R., Rowan, A. D., Goodyear, C., MacInnes, I. & Ferrell, W. R., Apr 2014, In : Osteoarthritis and Cartilage. 22, p. S369-S370

Research output: Contribution to journalMeeting Abstract

Open Access

Proteinase-activated receptor-2 critically influences osteophyte formation in experimental osteoarthritis

Huesa, C., McGavin, L., Lockhart, J. C., van't Hof, R., Plevin, R., Rowan, A., Goodyear, C., McInnes, I. B. & Ferrell, W. R., Apr 2014, In : Rheumatology. 53, Supplement 1, p. 49-49

Research output: Contribution to journalMeeting Abstract

2013
8 Citations (Scopus)

Proteinase-activated receptor-2 modulates human macrophage differentiation and effector function

Steven, R., Crilly, A., Lockhart, J. C., R. Ferrell, W. & McInnes, I. B., Dec 2013, In : Innate Immunity. 19, 6, p. 663-72 10 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)
2012

Correlation of protease-activated receptor-2 expression and synovitis in rheumatoid and osteoarthritis

Tindell, A. G., Kelso, E. B., Ferrell, W. R., Lockhart, J. C., Walsh, D. A., Dunning, L. & McInnes, I. B., Oct 2012, In : Rheumatology International. 32, 10, p. 3077-86 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Immunomodulatory role of proteinase-activated receptor-2

Crilly, A., Palmer, H., Nickdel, M. B., Dunning, L., Lockhart, J. C., Plevin, R., Mcinnes, I. B. & Ferrell, W. R., May 2012, In : Annals of the Rheumatic Diseases. 71, 9, p. 1559-1566 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

PAR(2) expression in peripheral blood monocytes of patients with rheumatoid arthritis

Crilly, A., Burns, E., Nickdel, M. B., Lockhart, J. C., Perry, M. E., Ferrell, P. W., Baxter, D., Dale, J., Dunning, L., Wilson, H., Nijjar, J. S., Gracie, J. A., Ferrell, W. R. & McInnes, I. B., Jun 2012, In : Annals of the Rheumatic Diseases. 71, 6, p. 1049-1054

Research output: Contribution to journalArticle

12 Citations (Scopus)

PAR-2 activation inhibits human osteoclast differentiation

McGavin, L., Freeburn, R., Crilly, A., Ferrell, W. R., Goodyear, C. S. & Lockhart, J. C., Sep 2012, In : Immunology. 137, S1, p. 231-231

Research output: Contribution to journalMeeting Abstract

2010

Matriptase Is a Novel Initiator of Cartilage Matrix Degradation in Osteoarthritis

Milner, J. M., Patel, A., Davidson, R. K., Swingler, T. E., Desilets, A., Young, D. A., Kelso, E. B., Donell, S. T., Cawston, T. E., Clark, I. M., Ferrell, W. R., Plevin, R., Lockhart, J. C., Leduc, R. & Rowan, A. D., Jul 2010, In : Arthritis and Rheumatism. 62, 7, p. 1955-1966

Research output: Contribution to journalArticle

56 Citations (Scopus)

Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis

Ferrell, W. R., Kelso, E. B., Lockhart, J. C., Plevin, R. & McInnes, I. B., Nov 2010, In : Annals of the Rheumatic Diseases. 69, 11, p. 2051-2054

Research output: Contribution to journalArticle

29 Citations (Scopus)

Proteinase-activated receptor-2 mediated inhibition of TNF alpha-stimulated JNK activation: A novel paradigm for G(q/11) linked GPCRs

McIntosh, K., Cunningham, M. R., Cadalbert, L., Lockhart, J., Boyd, G., Ferrell, W. R. & Plevin, R., Feb 2010, In : Cellular Signalling. 22, 2, p. 265-273

Research output: Contribution to journalArticle

7 Citations (Scopus)
2009

A model of chronic monoarthritis impairs EDHF but not NO activity in the saphenous artery of the rat

MacKenzie, A., Dunning, L., Ferrell, W. R. & Lockhart, J., Dec 2009, Proceedings of the British Pharmacological Society at http://www.pA2online.org/abstracts/Vol7Issue4abst004P.pdf . British Pharmacological Society, (pA2 Online; vol. 7, no. 4).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
2008

Angiotensin receptor blockers reduce erythrocyte sedimentation rate levels in patients with rheumatoid arthritis

Perry, M. E., Chee, M. M., Ferrell, W. R., Lockhart, J. C. & Sturrock, R. D., Nov 2008, In : Annals of the Rheumatic Diseases. 67, 11, p. 1646-1647

Research output: Contribution to journalLetter

15 Citations (Scopus)

Protease-activated receptor-2 (PAR-2): A potential new target in arthritis

R. Ferrell, W., Lockhart, J. & Plevin, R., 2008, In : Drugs of the Future. 33, 3, p. 241-248

Research output: Contribution to journalArticle

2 Citations (Scopus)
2007

Angiotensin II type 1 receptor as a novel therapeutic target in rheumatoid arthritis: In vivo analyses in rodent models of arthritis and ex vivo analyses in human inflammatory synovitis

Price, A., Lockhart, J., Ferrell, W. R., Gsell, W., McLean, S. & Sturrock, R. D., 2007, In : Arthritis & Rheumatology. 56, 2, p. 441-447 7 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Expression and pro-inflammatory role of proteinase-activated receptor 2 in rheumatoid synovium: ex vivo studies suing a novel proteinase-activated receptor-2 antagonist.

Kelso, E. B., Ferrell, W. R., Lockhart, J., Elias-Jones, I., Hembrough, T., Dunning, L., Gracie, J. A. & McInness, I. B., 2007, In : Arthritis & Rheumatology. 56, 3, p. 765-771 7 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Proteinase-activated receptor-2 (PAR2) mediates the pro-inflammatory effects of synovial mast cells.

Palmer, H. S., Kelso, E. B., Lockhart, J. C., Sommerhoff, C. P., Plevin, R., Goh, F. G. & Ferrell, W. R., 2007, In : Arthritis & Rheumatology. 56, 11, p. 3532-3540 9 p.

Research output: Contribution to journalArticle

2006

Therapeutic promise of proteinase-activated receptor-2 antagonism in joint inflammation

Kelso, E. B., Lockhart, J. C., Hembrough, T., Dunning, L., Plevin, R., Hollenberg, M. D., Sommerhoff, C. P., McLean, J. S. & Ferrell, W. R., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316, 3, p. 1017-1024 8 p.

Research output: Contribution to journalArticle

151 Citations (Scopus)