20012020

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Area of academic expertise - outline

I direct the Institute of Biomedical and Environmental Health Research (IBEHR) co-lead the Centre for Musculoskeletal Science (CMS) with Dr Carl Goodyear (University of Glasgow) investigating the pathogenesis of arthritis; this involves identifying novel therapeutic targets, and assessing novel therapeutic approaches.

The CMS is an established multi-institutional collaboration venture between the University of the West of Scotland, the University of Glasgow (Professor Iain McInnes) and the University of Strathclyde (Professor Robin Plevin), with a primary focus on regulatory mechanisms, and their disturbance during disease processes such as rheumatoid arthritis. Research spans fundamental to clinical levels.

Centre expertise includes clinical physiology, pharmacology, immunology, bioengineering and biotechnology. The group adopts an integrated system's approach combined with a molecular base of research to enable comprehensive investigations at cellular, genetic and functional levels.

As a physiologist and bioengineer, my biomedical research career to date has covered a range of diseases and conditions including diabetes, sickle cell anaemia, neonatology, hypertension and now arthritis.  This research has focused on inflammation, haemorheology and microvascular haemodynamics with regard to function and regulation, and involved in situ investigations of blood flow in synovial, renal and other microcirculations using laser Doppler, radiolabelled microspheres and videomicroscopy techniques.

Current research activities

Leadership Roles

I currently co-direct the Insitute of Biomedical & Environmental Health Research, and head the Centre for Musculoskeletal Science (www.uws.ac.uk/IBEHR). The latter is an inter-institutional and multidisciplinary research team with primary focus on arthritis.  Having published landmark ‘proof of concept’ papers identifying two novel therapeutic targets (PAR-2 and AT1 receptors) in rheumatoid/osteoarthritis, followed by translational studies to confirm the relevance of these findings to humans, our research programme now seek to elucidate their pathophysiological roles, develop and evaluate new drugs to target these receptors and establish down-stream signalling pathways. 

 

Arthritis Research UK £1.2m Programme

I am currently part of a consortium of universities that has been awarded a £1.2 million grant from Arthritis Research UK to bring together for the first time experts in bone, matrix, molecular and systems biology in a concerted effort to better understand osteoarthritis.  We have discovered a novel pathway involved in the development of osteoarthritis which could present a new approach to treatment of this disease.

The consortium integrates researchers at the Universities of Glasgow (Professor William Ferrell), Edinburgh ( Dr Robert van’t Hof), Newcastle (Professor Andrew Rowan) and Strathclyde (Professor Robin Plevin) and West of Scotland (Professor John Lockhart) in the study of a new pathway they previously discovered that may drive disease in osteoarthritis.  This could present an entirely new avenue for drug development. 

Desired research direction

COPD is an incurable and progressive lung condition characterised by progressive airflow reduction, breathing difficulties and irreversible lung damage and ranks as the 3rd leading cause of death world-wide. Despite the high prevalence of COPD and the associated mortality and morbidity within the Southwest of Scotland, there has been almost no research or training provision in this field. This lack within the both Southwest Scotland and Ireland has led to our planned partnered initiative to advance COPD research and training within these regions by establishing a new research training hub - BREATH.

Target collaborative companies

Companies interested in inflammatory diseases

Moor Instruments
AstraZeneca
Avanticell Science

External positions

Fellow, The Physiological Society (London)

1 Jan 2018 → …

Visiting Professor, University of Glasgow

1 Jan 2005 → …

Supporter, International da Vinci Decathalon

Member, Mayo Foundation Sigma Xi Community

Member, The Mayo Clinic & Foundation Alumni

Member, The Microcirculatory Society

Member, The Physiological Society (London)

Keywords

  • QP Physiology
  • Inflammation
  • Arthritis
  • Synovial microcirculation

Fingerprint Dive into the research topics where John Lockhart is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 8 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output

Exosomes in intercellular communication and implications for osteoarthritis

Asghar, S., Litherland, G. J., Lockhart, J. C., Goodyear, C. S. & Crilly, A., 1 Jan 2020, In : Rheumatology. 59, 1, p. 57-68 12 p.

Research output: Contribution to journalReview article

  • 3 Citations (Scopus)

    Accelerated post traumatic osteoarthritis in a dual injury murine model

    McCulloch, K., Huesa, C., Dunning, L., Litherland, G. J., Van't Hof, R. J., Lockhart, J. C. & Goodyear, C. S., 31 Dec 2019, In : Osteoarthritis and Cartilage. 27, 12, p. 1800-1810 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 2 Citations (Scopus)
    118 Downloads (Pure)

    Differential effects of exosomes derived from separate osteoarthritis synovial compartments: implications for erosive cartilage disease

    Asghar, S., Litherland, G., Meek, D., Cole, J., Lockhart, J., Goodyear, C. S. & Crilly, A., 30 Apr 2019, In : Osteoarthritis and Cartilage. 27, S1, p. S192 1 p., 260.

    Research output: Contribution to journalMeeting Abstract

  • 1 Citation (Scopus)

    Enhanced airway smooth muscle relaxation via proteinase activated receptor 2

    Black, K., MacKenzie, A., Dunning, L., Crilly, A., Brzeszczynska, J., McGarvey, L., Thornbury, K., Goodyear, C. S., Lockhart, J. C. & Litherland, G. J., 22 Nov 2019, In : Irish Journal of Medical Science. 188, SUPPL 10, p. 286-286 1 p.

    Research output: Contribution to journalMeeting Abstract

    Prizes

    Asthma/COPD Project of the Year, 19th Northern Ireland Healthcare Awards 2018

    Lorraine Martin (Recipient), Lorcan McGarvey (Recipient), Fionnuala Lundy (Recipient), Litherland, Gary (Recipient), Lockhart, John (Recipient), Crilly, Anne (Recipient), Carl Goodyear (Recipient), Keith Thornbury (Recipient), Mark Hollywood (Recipient), Gerard Sergeant (Recipient) & Noel McHale (Recipient), 22 Feb 2018

    Prize: National/international honour

    Northern Ireland Healthcare Awards

    Lockhart, John (Recipient), 22 Feb 2018

    Prize: Prize (including medals and awards)

  • Activities

    BREATH Dumfries & Galloway Schools Engagement Drive: Belmont Primary award

    John Lockhart (Presenter)

    10 Feb 2020

    Activity: OtherTypes of Public engagement and outreach - Festival/Exhibition

    BREATH Presentation at Stranraer Campus, Dumfries & Galloway College

    John Lockhart (Speaker)

    10 Feb 2020

    Activity: OtherTypes of Public engagement and outreach - Festival/Exhibition

    BREATH Dumfries & Galloway Schools Engagement Drive: Stranraer Academy

    John Lockhart (Speaker)

    10 Feb 2020

    Activity: OtherTypes of Public engagement and outreach - Festival/Exhibition

    Internal Examiner for MPhil

    John Lockhart (Examiner)

    17 Jan 2019

    Activity: Examination

    BREATH team meeting with Clinical team at Ayr Hospital

    John Lockhart (Participant), , Gary Litherland (Organiser), , Joanna Brzeszczynska (Participant), , Karen Bell (Participant), & Anur Guhan (Participant)

    28 Feb 2019

    Activity: Other

    Press / Media

    School Showcase - Kirkcudbright

    John Lockhart

    6/05/19

    1 item of Media coverage

    Press/Media: Public Engagement Activities

    Health Matters (Galloway News)

    John Lockhart

    6/12/18

    1 Media contribution

    Press/Media: Public Engagement Activities

    Profiles