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Personal profile

Area of academic expertise - outline

I direct the Institute of Biomedical and Environmental Health Research (IBEHR) co-lead the Centre for Musculoskeletal Science (CMS) with Dr Carl Goodyear (University of Glasgow) investigating the pathogenesis of arthritis; this involves identifying novel therapeutic targets, and assessing novel therapeutic approaches.

The CMS is an established multi-institutional collaboration venture between the University of the West of Scotland, the University of Glasgow (Professor Iain McInnes) and the University of Strathclyde (Professor Robin Plevin), with a primary focus on regulatory mechanisms, and their disturbance during disease processes such as rheumatoid arthritis. Research spans fundamental to clinical levels.

Centre expertise includes clinical physiology, pharmacology, immunology, bioengineering and biotechnology. The group adopts an integrated system's approach combined with a molecular base of research to enable comprehensive investigations at cellular, genetic and functional levels.

As a physiologist and bioengineer, my biomedical research career to date has covered a range of diseases and conditions including diabetes, sickle cell anaemia, neonatology, hypertension and now arthritis.  This research has focused on inflammation, haemorheology and microvascular haemodynamics with regard to function and regulation, and involved in situ investigations of blood flow in synovial, renal and other microcirculations using laser Doppler, radiolabelled microspheres and videomicroscopy techniques.

Current research activities

Leadership Roles

I currently co-direct the Insitute of Biomedical & Environmental Health Research, and head the Centre for Musculoskeletal Science (www.uws.ac.uk/IBEHR). The latter is an inter-institutional and multidisciplinary research team with primary focus on arthritis.  Having published landmark ‘proof of concept’ papers identifying two novel therapeutic targets (PAR-2 and AT1 receptors) in rheumatoid/osteoarthritis, followed by translational studies to confirm the relevance of these findings to humans, our research programme now seek to elucidate their pathophysiological roles, develop and evaluate new drugs to target these receptors and establish down-stream signalling pathways. 

 

Arthritis Research UK £1.2m Programme

I am currently part of a consortium of universities that has been awarded a £1.2 million grant from Arthritis Research UK to bring together for the first time experts in bone, matrix, molecular and systems biology in a concerted effort to better understand osteoarthritis.  We have discovered a novel pathway involved in the development of osteoarthritis which could present a new approach to treatment of this disease.

The consortium integrates researchers at the Universities of Glasgow (Professor William Ferrell), Edinburgh ( Dr Robert van’t Hof), Newcastle (Professor Andrew Rowan) and Strathclyde (Professor Robin Plevin) and West of Scotland (Professor John Lockhart) in the study of a new pathway they previously discovered that may drive disease in osteoarthritis.  This could present an entirely new avenue for drug development. 

Desired research direction

COPD is an incurable and progressive lung condition characterised by progressive airflow reduction, breathing difficulties and irreversible lung damage and ranks as the 3rd leading cause of death world-wide. Despite the high prevalence of COPD and the associated mortality and morbidity within the Southwest of Scotland, there has been almost no research or training provision in this field. This lack within the both Southwest Scotland and Ireland has led to our planned partnered initiative to advance COPD research and training within these regions by establishing a new research training hub - BREATH.

Target collaborative companies

Companies interested in inflammatory diseases

Moor Instruments
AstraZeneca
Avanticell Science

External positions

Fellow, The Physiological Society (London)

1 Jan 2018 → …

Visiting Professor, University of Glasgow

1 Jan 2005 → …

Supporter, International da Vinci Decathalon

Member, Mayo Foundation Sigma Xi Community

Member, The Mayo Clinic & Foundation Alumni

Member, The Microcirculatory Society

Member, The Physiological Society (London)

Keywords

  • QP Physiology
  • Inflammation
  • Arthritis
  • Synovial microcirculation

Fingerprint Dive into the research topics where John Lockhart is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 10 Similar Profiles
PAR-2 Receptor Medicine & Life Sciences
Osteoarthritis Medicine & Life Sciences
Joints Medicine & Life Sciences
Cartilage Medicine & Life Sciences
Arthritis Medicine & Life Sciences
Tibial Meniscus Medicine & Life Sciences
Rheumatoid Arthritis Medicine & Life Sciences
Exosomes Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2001 2019

34 Downloads (Pure)

Accelerated post traumatic osteoarthritis in a dual injury murine model

McCulloch, K., Huesa, C., Dunning, L., Litherland, G. J., Van't Hof, R. J., Lockhart, J. C. & Goodyear, C. S., 5 Jul 2019, In : Osteoarthritis and Cartilage.

Research output: Contribution to journalArticle

Open Access
File
Cartilage
Osteoarthritis
Wounds and Injuries
Ligaments
Osteophyte

Differential effects of exosomes derived from separate osteoarthritis synovial compartments: implications for erosive cartilage disease

Asghar, S., Litherland, G., Meek, D., Cole, J., Lockhart, J., Goodyear, C. S. & Crilly, A., 30 Apr 2019, In : Osteoarthritis and Cartilage. 27, S1, p. S192 1 p., 260.

Research output: Contribution to journalMeeting Abstract

Cartilage Diseases
Exosomes
Cartilage
Osteoarthritis
RNA

Evaluation of novel serine protease inhibitors to ameliorate cockroach-induced airway inflammation and cell damage

Reihill, J., Yang, Z., Carroll, E., McGarvey, L., Lundy, F., Lockhart, J., Sergeant, G. & Martin, L., 6 Apr 2019.

Research output: Contribution to conferenceAbstract

Cockroaches
Serine Proteinase Inhibitors
Inflammation

Inhibition of ENaC activity by novel peptide trypsin-like inhibitors derived from amphibian skin secretions

Carroll, E., Chen, T., Douglas, L., Hollywood, M., Lockhart, J., Martin, S. L., Lundy, F., McGarvey, L., Reihill, J. & Zhou, M., 6 Apr 2019.

Research output: Contribution to conferenceAbstract

Trypsin Inhibitors
Amphibians
Skin
Peptides

PAR2 accelerates osteoarthritis-like joint changes in a murine model of post-traumatic osteoarthritis

Goodyear, C., McCulloch, K., Huesa, C., Dunning, L., van 't Hof, R. & Lockhart, J., 27 Jun 2019, In : Annals of the Rheumatic Diseases. 78, Issue Suppl 2, p. 110-110 1 p.

Research output: Contribution to journalMeeting Abstract

Open Access
PAR-2 Receptor
Osteoarthritis
Joints
Cartilage
Tibial Meniscus

Prizes

Asthma/COPD Project of the Year, 19th Northern Ireland Healthcare Awards 2018

Lorraine Martin (Recipient), Lorcan McGarvey (Recipient), Fionnuala Lundy (Recipient), Gary Litherland (Recipient), John Lockhart (Recipient), Anne Crilly (Recipient), Carl Goodyear (Recipient), Keith Thornbury (Recipient), Mark Hollywood (Recipient), Gerard Sergeant (Recipient) & Noel McHale (Recipient), 22 Feb 2018

Prize: National/international honour

Northern Ireland Healthcare Awards

John Lockhart (Recipient), 22 Feb 2018

Prize: Prize (including medals and awards)

Northern Ireland
Chronic Obstructive Pulmonary Disease
Asthma
Delivery of Health Care

Activities 2015 2019

GSK Site Visit

John Lockhart (Organiser), Mark Thomas (Participant), Kimberly Black (Participant), Kirsty McCallum (Participant), Carly Woods (Participant), Bryn Short (Participant), Sabha Asghar (Participant), Fawziye Tarhini (Participant), Mari Bailo (Participant), Gary Litherland (Organiser), Anne Crilly (Organiser)
14 Mar 201915 Mar 2019

Activity: Participating in or organising an eventParticipation in workshop, seminar, course

BREATH PI Meeting, Belfast (QUB)

John Lockhart (Speaker), Anne Crilly (Speaker), Gary Litherland (Speaker)
15 Jan 2019

Activity: Participating in or organising an eventParticipation in workshop, seminar, course

European Respiratory Society International Congress

John Lockhart (Participant), Gary Litherland (Participant), Anne Crilly (Participant), Joanna Brzeszczynska (Participant), Lynette Dunning (Participant)
28 Sep 20192 Oct 2019

Activity: Participating in or organising an eventParticipation in conference

BREATH Schools Public Engagement: Dumfries & Galloway (St Joseph's College)

John Lockhart (Presenter), Carly Woods (Presenter)
13 Mar 2019

Activity: OtherTypes of Public engagement and outreach - Festival/Exhibition

Glasgow Science Fair (Paisley)

John Lockhart (Participant), Anne Crilly (Participant), Andrew MacKenzie (Participant), Bryn Short (Participant), Mari Bailo (Participant), Mark Thomas (Participant), Kimberly Black (Participant), Kirsty McCallum (Participant), Fawziye Tarhini (Participant), Carly Woods (Participant)
6 Jun 2019

Activity: OtherTypes of Public engagement and outreach - Festival/Exhibition

Profiles

Exosomes
Osteoarthritis
Cartilage
Cartilage Diseases
Pathology
Osteoarthritis
Tibial Meniscus
Joint Diseases
Pathology
Joints
Osteoarthritis
Tibial Meniscus
Cartilage
Joints
Osteophyte
Interferons
Antiviral Agents
Viruses
Cytomegalovirus
Human respiratory syncytial virus