Personal profile
Overview
In 2017, I earned my PhD in Infection and Immunity from the University of Glasgow, where I worked under the mentorship of Prof. Markus Meissner. My doctoral research focused on unravelling the complexities of parasitic invasion mechanisms of Toxoplasma gondii. Following this, I spent six years as a postdoctoral researcher at the CRUK Beatson Institute, collaborating with Prof. Laura Machesky to investigate the intricacies of cancer cell migration.
Throughout my research career, I’ve leveraged cutting-edge gene-editing techniques to generate genetic knockout models in both mammalian cells and parasites. One of my key contributions was deciphering the invasion machinery of Toxoplasma gondii using knockout strategies to pinpoint essential proteins for the parasite’s survival. During my time at CRUK, I played a crucial role in the characterisation of the previously unknown gene Fam49B, now recognised as CYRI-B (Cyfip-related Rac Interactor-B). This work revealed CYRI-B as the first known negative regulator of the Scar/WAVE complex, which controls cell migration by regulating actin dynamics at the leading edge.
My expertise spans molecular and cellular biology, biochemistry, large-scale omics, and some in vivo studies. However, my primary focus has been on microscopy, utilising various advanced imaging techniques to explore the actin cytoskeleton. My imaging work has earned multiple awards, including features on the cover of Focal Plane.
Now, as a lecturer at the University of the West of Scotland (UWS), I teach mainly on biomedical sciences and the MSc One Health, while continuing my research on host-pathogen interactions, with a particular emphasis on Toxoplasma gondii. My current work focuses on the host factors that facilitate parasite entry and understanding how Toxoplasma selects its host cells.
External positions
Post doctoral Researcher, CRUK Beatson Institute
Oct 2016 → Jul 2022
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Emergence of PHMB resistance in Acanthamoeba castellanii and observations on cross-resistance to other frontline therapeutics
Mooney, R., Whitelaw, J., Woods, S. & Henriquez, F., 4 Jan 2026, (E-pub ahead of print) In: Current Eye Research. 5 p., 2607477.Research output: Contribution to journal › Article › peer-review
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CYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge
Whitelaw, J. A., Ghosh, S., Lilla, S., Nikolaou, S., Tweedy, L., Fort, L., Paul, N. R., Zanivan, S., Gadegaard, N., Insall, R. H. & Machesky, L. M., 24 Nov 2025, In: Journal of Cell Science. 138, 22, 17 p., 263646.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
First person – Jamie Whitelaw
Whitelaw, J., 25 Nov 2025, 2 p. Journal of Cell Science.Research output: Other contribution
Open AccessFile1 Downloads (Pure) -
CYRI-B mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake
Nikolaou, S., Juin, A., Whitelaw, J. A., Paul, N., Fort, L., Nixon, C., Spence, H. J., Bryson, S. & Machesky, L. M., 7 May 2024, (E-pub ahead of print) In: eLife. 83712.Research output: Contribution to journal › Article › peer-review
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Scar/WAVE drives actin protrusions independently of its VCA domain using proline-rich domains
Buracco, S., Döring, H., Engelbart, S., Singh, S. P., Paschke, P., Whitelaw, J., Thomason, P. A., Paul, N. R., Tweedy, L., Lilla, S., McGarry, L., Corbyn, R., Claydon, S., Mietkowska, M., Machesky, L. M., Rottner, K. & Insall, R. H., 26 Sept 2024, (E-pub ahead of print) In: Current Biology. 26 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile100 Downloads (Pure)
Activities
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STEM West 2025
Whitelaw, J. (Examiner)
18 Nov 2025Activity: Other › Types of Public engagement and outreach - Schools engagement
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McLaren High School- STEM Careers Fair
Whitelaw, J. (Examiner)
8 Oct 2024Activity: Other › Types of Public engagement and outreach - Schools engagement
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SULSA Strategic Groups - Infectious diseases
Whitelaw, J. (Invited speaker)
2023Activity: Participating in or organising an event › Participation in workshop, seminar, course
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UWS Crucible 2023
Whitelaw, J. (Participant)
2023Activity: Participating in or organising an event › Participation in workshop, seminar, course