Research output per year
Research output per year
Dr
Accepting PhD Students
Willing to speak to media
Research activity per year
I am a cell biologist with interests in pro-inflammatory signalling networks and regulation of gene expression, especially with regard to the activity of proteases and extracellular matrix turnover in disease, particularly osteoarthritis and co-morbidities such as obesity.
Consequently I have applied expertise in joint/cartilage and adipose tissue biology and a range of techniques encompassing in vivo disease and exercise models, tissue explant and 2D/3D cell culture, immunohisto/cytochemistry, microscopy, protein chemistry and proteolysis (particularly matrix metalloproteinases), gene expression modification and transcriptomic analyses, in order to study disease mechanisms.
My primary research focus is on elucidating the molecular mechanisms underpinning the importance of proteinase-activated receptor 2 (PAR2) in osteoarthritis, the most prevalent musculoskeletal disease. PAR2 exhibits profound roles in joint destruction/remodelling, inflammation and pain, making this protease sensor an attractive potential target for new therapeutics. This work has been a key stimulus leading me to develop new and collaborative interests in complementary areas such as bone biology, exercise physiology, mechanotransduction, wound healing and mesenchymal stem cells.
I have recently become very active in respiratory science as part of BREATH (Border and REgions Airways Training Hub): a major cross-border partnership (academic/clinical/enterprise) focused on better understanding, treatment, diagnosis, management and awareness of chronic obstructive pulmonary disease (COPD). I lead studies elucidating novel roles for PARs and other therapeutic targets in premature lung aging, airway epithelial and smooth muscle function, and regulation of key ion channels.
The goal of my research on PAR2 and other therapeutic targets is to inform and facilitate the development of new therapeutic agents that will positively impact the lives of patients blighted by chronic diseases such as osteoarthritis and COPD. As my work continues to yield new insights into disease mechanisms and illuminate novel potential drug targets, I will seek to exploit this knowledge and expertise in partnership with commercial organisations, to expedite translation of scientific findings toward solutions realising patient benefit.
NHS
Universities (Glasgow, Strathclyde, Newcastle, Liverpool)
Charities (e.g. Arthritis Research UK)
Life Science (SME)
Pharma
Honorary Lecturer, University of Glasgow
1 Apr 2014 → 31 Mar 2019Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Meeting Abstract › peer-review
Research output: Contribution to journal › Meeting Abstract › peer-review
Research output: Contribution to conference › Poster
Research output: Contribution to journal › Meeting Abstract › peer-review
Lorraine Martin (Recipient), Lorcan McGarvey (Recipient), Fionnuala Lundy (Recipient), Litherland, Gary (Recipient), Lockhart, John (Recipient), Crilly, Anne (Recipient), Carl Goodyear (Recipient), Keith Thornbury (Recipient), Mark Hollywood (Recipient), Gerard Sergeant (Recipient) & Noel McHale (Recipient), 22 Feb 2018
Prize: National/international honour
Anne Crilly (Organiser), John Lockhart (Organiser), Gary Litherland (Organiser), Joanna Brzeszczynska (Participant), Lynette Dunning (Participant), Kirsty McCallum (Speaker), Carly Woods (Speaker), Kimberly Black (Speaker), Bryn Short (Speaker), Mark Thomas (Speaker), Fawziye Tarhini (Speaker) & Mari Bailo (Speaker)
Activity: Participating in or organising an event › Participation in conference
Anne Crilly (Organiser), Gary Litherland (Participant) & John Lockhart (Participant)
Activity: Other
John Lockhart (Speaker), Anne Crilly (Speaker) & Gary Litherland (Speaker)
Activity: Participating in or organising an event › Participation in workshop, seminar, course
John Lockhart (Member), Gary Litherland (Member) & Anne Crilly (Member)
Activity: Other › Types of Public engagement and outreach - Festival/Exhibition
John Lockhart (Participant), Andrew MacKenzie (Organiser), Gary Litherland (Participant), Anne Crilly (Participant), William MacKay (Participant), Craig Williams (Participant), Joanna Brzeszczynska (Participant), Mariarca Bailo (Presenter), Kirsty McCallum (Presenter), Kimberly Black (Presenter), Fawziye Tarhini (Presenter), David Anderson (Participant), Hannah Bayes (Participant), Pallavai Bedi (Participant), Carly Woods (Presenter) & Bryn Short (Presenter)
Activity: Other
John Lockhart, Anne Crilly, Gary Litherland, Kimberly Black, Kirsty McCallum & Mariarca Bailo
6/12/18
1 item of Media coverage
Press/Media: Public Engagement Activities
John Lockhart, Gary Litherland, Anne Crilly, Carl Goodyear, Andrew MacKenzie, Iain McLellan, Andisheh Bakhshi, Lynette Dunning, Robin Freeburn, William MacKay, Craig Williams, Kirsty McCallum, Mariarca Bailo, Kimberly Black, Bryn Short, Mark Thomas & Fawziye Tarhini
7/11/18
1 Media contribution
Press/Media: Other
John Lockhart, Anne Crilly, Gary Litherland, Iain McLellan, Kimberly Black, Kirsty McCallum, Mark Thomas, Mariarca Bailo & Fawziye Tarhini
12/10/18
1 item of Media coverage
Press/Media: Public Engagement Activities
John Lockhart, Anne Crilly, Gary Litherland, Iain McLellan, Carl Goodyear, Kirsty McCallum, Kimberly Black, Mariarca Bailo, Mark Thomas & Bryn Short
11/10/18
1 item of Media coverage
Press/Media: Public Engagement Activities
John Lockhart, Gary Litherland, Anne Crilly, Carl Goodyear, Lorraine Martin, Keith Thornbury, Mark Hollywood, Gerard Sergeant, Fionnuala Lundy & Lorcan McGarvey
9/03/18
1 item of Media coverage
Press/Media: Research