19992020

Research output per year

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Personal profile

Area of academic expertise - outline

I am a cell biologist with interests in pro-inflammatory signalling networks and regulation of gene expression, especially with regard to the activity of proteases and extracellular matrix turnover in disease, particularly osteoarthritis and co-morbidities such as obesity.

Consequently I have applied expertise in joint/cartilage and adipose tissue biology and a range of techniques encompassing in vivo disease and exercise models, tissue explant and 2D/3D cell culture, immunohisto/cytochemistry, microscopy, protein chemistry and proteolysis (particularly matrix metalloproteinases), gene expression modification and transcriptomic analyses, in order to study disease mechanisms.

Current research activities

My primary research focus is on elucidating the molecular mechanisms underpinning the importance of proteinase-activated receptor 2 (PAR2) in osteoarthritis, the most prevalent musculoskeletal disease. PAR2 exhibits profound roles in joint destruction/remodelling, inflammation and pain, making this protease sensor an attractive potential target for new therapeutics. This work has been a key stimulus leading me to develop new and collaborative interests in complementary areas such as bone biology, exercise physiology, mechanotransduction, wound healing and mesenchymal stem cells.

I have recently become very active in respiratory science as part of BREATH (Border and REgions Airways Training Hub): a major cross-border partnership (academic/clinical/enterprise) focused on better understanding, treatment, diagnosis, management and awareness of chronic obstructive pulmonary disease (COPD). I lead studies elucidating novel roles for PARs and other therapeutic targets in premature lung aging, airway epithelial and smooth muscle function, and regulation of key ion channels.

 

Desired research direction

The goal of my research on PAR2 and other therapeutic targets is to inform and facilitate the development of new therapeutic agents that will positively impact the lives of patients blighted by chronic diseases such as osteoarthritis and COPD. As my work continues to yield new insights into disease mechanisms and illuminate novel potential drug targets, I will seek to exploit this knowledge and expertise in partnership with commercial organisations, to expedite translation of scientific findings toward solutions realising patient benefit.  

Target collaborative organisations

NHS

Universities (Glasgow, Strathclyde, Newcastle, Liverpool)

Charities (e.g. Arthritis Research UK)

Target collaborative companies

Life Science (SME)

Pharma

External positions

Honorary Lecturer, University of Glasgow

1 Apr 201431 Mar 2019

Keywords

  • QP Physiology
  • Arthritis
  • Osteoarthritis
  • Chronic Obstructive Pulmonary Disease
  • Cartilage
  • Adipose
  • Inflammation
  • Protease
  • Extracellular Matrix
  • Matrix Metalloproteinase
  • Obesity
  • Proteinase-activated receptor 2
  • Cell Signalling
  • Gene expression
  • Cytokine
  • Tissue Remodelling
  • Leptin
  • Chondrocyte

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Research Output

Exosomes in intercellular communication and implications for osteoarthritis

Asghar, S., Litherland, G. J., Lockhart, J. C., Goodyear, C. S. & Crilly, A., 1 Jan 2020, In : Rheumatology. 59, 1, p. 57-68 12 p.

Research output: Contribution to journalReview article

  • 3 Citations (Scopus)

    Accelerated post traumatic osteoarthritis in a dual injury murine model

    McCulloch, K., Huesa, C., Dunning, L., Litherland, G. J., Van't Hof, R. J., Lockhart, J. C. & Goodyear, C. S., 31 Dec 2019, In : Osteoarthritis and Cartilage. 27, 12, p. 1800-1810 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 2 Citations (Scopus)
    118 Downloads (Pure)

    beta-Adrenoreceptor agonists inhibit M-2 muscarinic receptor-mediated contractions of murine bronchial rings

    Alkawadri, T., Thornbury, K. D., Hollywood, M. A., McGarvey, L., Lundy, F., Litherland, G. & Sergeant, G. P., Nov 2019, In : Irish Journal of Medical Science. 188, SUPPL 10, p. 268-268 1 p.

    Research output: Contribution to journalMeeting Abstract

    Differential effects of exosomes derived from separate osteoarthritis synovial compartments: implications for erosive cartilage disease

    Asghar, S., Litherland, G., Meek, D., Cole, J., Lockhart, J., Goodyear, C. S. & Crilly, A., 30 Apr 2019, In : Osteoarthritis and Cartilage. 27, S1, p. S192 1 p., 260.

    Research output: Contribution to journalMeeting Abstract

  • 1 Citation (Scopus)

    Prizes

    Asthma/COPD Project of the Year, 19th Northern Ireland Healthcare Awards 2018

    Lorraine Martin (Recipient), Lorcan McGarvey (Recipient), Fionnuala Lundy (Recipient), Litherland, Gary (Recipient), Lockhart, John (Recipient), Crilly, Anne (Recipient), Carl Goodyear (Recipient), Keith Thornbury (Recipient), Mark Hollywood (Recipient), Gerard Sergeant (Recipient) & Noel McHale (Recipient), 22 Feb 2018

    Prize: National/international honour

    Fellow

    Litherland, Gary (Recipient), 2014

    Prize: Election to learned society

    Activities

    BREATH team meeting with Clinical team at Ayr Hospital

    John Lockhart (Participant), , Gary Litherland (Organiser), , Joanna Brzeszczynska (Participant), , Karen Bell (Participant), & Anur Guhan (Participant)

    28 Feb 2019

    Activity: Other

    GSK Site Visit

    John Lockhart (Organiser), , Mark Thomas (Participant), , Kimberly Black (Participant), , Kirsty McCallum (Participant), , Sabha Asghar (Participant), , Fawziye Tarhini (Participant), , Mari Bailo (Participant), , Gary Litherland (Organiser), , Anne Crilly (Organiser), , Carly Woods (Participant), & Bryn Short (Participant)

    14 Mar 201915 Mar 2019

    Activity: Participating in or organising an eventParticipation in workshop, seminar, course

    Gourab Choudhury

    John Lockhart (Host), , Anne Crilly (Host), & Gary Litherland (Host)

    27 Nov 2019

    Activity: Hosting a visitorHosting an academic visitor

    BREATH team meeting with Clinical & Biomedical Team at Dumfries & Galloway Royal Infirmary

    John Lockhart (Organiser), , Gary Litherland (Organiser), , Joanna Brzeszczynska (Participant), , Carly Woods (Participant), , Phyllis Murphie (Participant), & Adele Foster (Participant)

    13 Mar 2019

    Activity: Other

    World COPD Day 2019

    John Lockhart (Examiner), , Kimberly Black (Examiner), , Kirsty McCallum (Examiner), , Mark Thomas (Examiner), , Fawziye Tarhini (Examiner), , Mari Bailo (Examiner), , Gary Litherland (Examiner), , Anne Crilly (Examiner), , William MacKay (Examiner), , Carly Woods (Examiner), & Bryn Short (Examiner)

    20 Nov 2019

    Activity: OtherTypes of Public engagement and outreach - Festival/Exhibition

    Press / Media

    Profiles