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Research Output

2020

Characterisation of exosomes isolated by ultracentrifugation from human primary bronchial epithelial cells

Downey, N., McGarvey, L., Martin, S. L., Crilly, A. & Lundy, F. T., 3 Feb 2020, In : Lung. 198, 1, p. 36-36 1 p.

Research output: Contribution to journalMeeting Abstract

Exosomes in intercellular communication and implications for osteoarthritis

Asghar, S., Litherland, G. J., Lockhart, J. C., Goodyear, C. S. & Crilly, A., 1 Jan 2020, In : Rheumatology. 59, 1, p. 57-68 12 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)
2019

Differential effects of exosomes derived from separate osteoarthritis synovial compartments: implications for erosive cartilage disease

Asghar, S., Litherland, G., Meek, D., Cole, J., Lockhart, J., Goodyear, C. S. & Crilly, A., 30 Apr 2019, In : Osteoarthritis and Cartilage. 27, S1, p. S192 1 p., 260.

Research output: Contribution to journalMeeting Abstract

1 Citation (Scopus)

Enhanced airway smooth muscle relaxation via proteinase activated receptor 2

Black, K., MacKenzie, A., Dunning, L., Crilly, A., Brzeszczynska, J., McGarvey, L., Thornbury, K., Goodyear, C. S., Lockhart, J. C. & Litherland, G. J., 22 Nov 2019, In : Irish Journal of Medical Science. 188, SUPPL 10, p. 286-286 1 p.

Research output: Contribution to journalMeeting Abstract

Healthy primary epithelial cells show an elevated inflammatory response to bacterial stimulus compared to COPD cells

Carson, S. A., Reihill, J. A., Fulton, C. R., McGarvey, L. P., Lundy, F. T., Crilly, A. & Thornbury, K. D., 1 Apr 2019, In : The FASEB Journal. 33, Supplement 1, 127.7.

Research output: Contribution to journalMeeting Abstract

Proteinase activated receptor 2 (PAR2) modulation of murine airway function

Black, K., MacKenzie, A., Dunning, L., Crilly, A., Brzeszczyńska, J., McGarvey, L., Thornbury, K., Goodyear, C. S., Lockhart, J. & Litherland, G., 10 Sep 2019.

Research output: Contribution to conferencePoster

Open Access
File
8 Downloads (Pure)

Proteinase activated receptor 2 modulates expression of autophagy markers in murine lungs

McCallum, K., Dunning, L., McGarvey, L., Hollywood, M., Goodyear, C. S., Brzeszczynska, J., Crilly, A., Lockhart, J. C. & Litherland, G. J., 22 Nov 2019, In : Irish Journal of Medical Science. 188, SUPPL 10, p. S270-S270 1 p., 2.6.

Research output: Contribution to journalMeeting Abstract

Understanding PAR2 matriptase ENaC crosstalk in the lung: implications for COPD

Bailo, M., Dunning, L., Brzeszczynska, J., Martin, S. L., Sergeant, G. P., Goodyear, C. S., Litherland, G. J., Lockhart, J. C. & Crilly, A., 30 Nov 2019, In : Irish Journal of Medical Science. 188, SUPPL 10, p. 268-269 2 p.

Research output: Contribution to journalMeeting Abstract

2018

Assessment of the effects of exercise on a murine model of OA

Huesa, C., Dunning, L., Macdougall, K., Ortiz, A., Villaluz, M. M., Fegen, M., Crilly, A., Litherland, G., MacKenzie, A., van't Hof, R., Goodyear, C. & Lockhart, J., 30 Apr 2018, In : Osteoarthritis and Cartilage. 26, Supplement 1, p. s68 1 p.

Research output: Contribution to journalMeeting Abstract

Healthy primary epithelial cells show an elevated inflammatory response to bacterial stimulus compared to COPD cells

Carson, S., Reihill, J. A., Fulton, C. R., McGarvey, L. P., Lundy, F. T., Crilly, A., Thornbury, K. D. & Martin, S. L., 8 Oct 2018, In : Irish Journal of Medical Science. 187, Supplement 8, p. S271-S271 1 p.

Research output: Contribution to journalMeeting Abstract

Inhibition of ENaC activity by novel peptide trypsin-like inhibitors derived from amphibian skin secretions

Carroll, E. L., Douglas, L. E. J., Reihill, J. A., Zhou, M., Chen, T., McGarvey, L. P., Lundy, F. T., Hollywood, M. A., Crilly, A., Lockhart, J. C. & Martin, S. L., Aug 2018, In : Irish Journal of Medical Science. 187, Supplement 8, p. S250-S251 2 p.

Research output: Contribution to journalMeeting Abstract

Isolation and characterisation of exosomes from human primary bronchial epithelial cells

Lockhart, J., Downey, N., McGarvey, L., Martin, L., Crilly, A., Reihill, J. & Lundy, F., 2018, In : Irish Journal of Medical Science. 187, Supplement 8, p. S252-S252 1 p.

Research output: Contribution to journalMeeting Abstract

Proteinase activated receptor 2 (PAR2) modulation of airway smooth muscle function

Black, K., MacKenzie, A., Dunning, L., Crilly, A., McGarvey, L., Thornbury, K., Goodyear, C., Lockhart, J. & Litherland, G., 8 Oct 2018, In : Irish Journal of Medical Science. 187, Supplement 8, p. S249-S249 1 p.

Research output: Contribution to journalMeeting Abstract

Open Access
File
22 Downloads (Pure)

Rheumatic disease: protease-activated receptor-2 in synovial joint pathobiology

McCulloch, K., McGrath, S., Huesa, C., Dunning, L., Litherland, G., Crilly, A., Hultin, L., Ferrell, W. R., Lockhart, J. & Goodyear, C., 23 May 2018, In : Frontiers in Endocrinology. 9, 257.

Research output: Contribution to journalReview article

Open Access
1 Citation (Scopus)

The synovial secretome contributes to cartilage pathology in osteoarthritis: a role for exosomes

Asghar, S., Litherland, G., Meek, D., Goodyear, C., Lockhart, J. & Crilly, A., 30 Apr 2018, In : Osteoarthritis and Cartilage. 26, Supplement 1, p. s131-s132 2 p., 248.

Research output: Contribution to journalMeeting Abstract

2017

The synovial secretome contributes to cartilage pathology in osteoarthritis (OA): an Exosome Study

Asghar, S., Litherland, G., Meek, D., Goodyear, C., Lockhart, J. & Crilly, A., 5 Dec 2017, (Accepted/In press).

Research output: Contribution to conferencePoster

2016

Evaluating the impact of protease activated receptor 2 (PAR2) gene disruption on T regulatory cell biology

Crilly, A., Cochrane, D., Plevin, R., Ferrell, W. R., McInness, I. B., Goodyear, C. & Lockhart, J., 8 Dec 2016.

Research output: Contribution to conferencePoster

Open Access

Proteinase-activated Receptor 2: Potential Role in Osteoarthritic Entheseal Pathology

Ortiz, A., Dunning, L., Huesa, C., Ferrell, W. R., McInnes, I. B., Lockhart, J., Millar, N. L., Goodyear, C. S. & Crilly, A., 27 Oct 2016, In : Orthopaedic Proceedings. 98-B, Suppl. 16

Research output: Contribution to journalMeeting Abstract

Open Access

Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology

Huesa, C., Ortiz, A. C., Dunning, L., McGavin, L., Bennett, L., McIntosh, K., Crilly, A., Kurowska-Stolarska, M., Plevin, R., van 't Hof, R. J., Rowan, A. D., McInnes, I. B., Goodyear, C. S., Lockhart, J. C. & Ferrell, W. R., 11 Oct 2016, In : Annals of the Rheumatic Diseases. 75, 11, p. 1989-1997

Research output: Contribution to journalArticle

Open Access
25 Citations (Scopus)
2015

Differential Inflammatory Profile in Experimental Models of Arthritis

Ortiz, A. C., Crilly, A., Dunning, L., Huesa, C., Goodyear, C. S., Lockhart, J. C., Ferrell, W. R. & McInnes, I. B., Oct 2015, In : Arthritis & Rheumatology. 67, 1139.

Research output: Contribution to journalMeeting Abstract

Open Access
2013

Proteinase-activated receptor-2 modulates human macrophage differentiation and effector function

Steven, R., Crilly, A., Lockhart, J. C., R. Ferrell, W. & McInnes, I. B., Dec 2013, In : Innate Immunity. 19, 6, p. 663-72 10 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)
2012

Immunomodulatory role of proteinase-activated receptor-2

Crilly, A., Palmer, H., Nickdel, M. B., Dunning, L., Lockhart, J. C., Plevin, R., Mcinnes, I. B. & Ferrell, W. R., May 2012, In : Annals of the Rheumatic Diseases. 71, 9, p. 1559-1566 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

PAR(2) expression in peripheral blood monocytes of patients with rheumatoid arthritis

Crilly, A., Burns, E., Nickdel, M. B., Lockhart, J. C., Perry, M. E., Ferrell, P. W., Baxter, D., Dale, J., Dunning, L., Wilson, H., Nijjar, J. S., Gracie, J. A., Ferrell, W. R. & McInnes, I. B., Jun 2012, In : Annals of the Rheumatic Diseases. 71, 6, p. 1049-1054

Research output: Contribution to journalArticle

12 Citations (Scopus)

PAR-2 activation inhibits human osteoclast differentiation

McGavin, L., Freeburn, R., Crilly, A., Ferrell, W. R., Goodyear, C. S. & Lockhart, J. C., Sep 2012, In : Immunology. 137, S1, p. 231-231

Research output: Contribution to journalMeeting Abstract

2011

Phosphodiesterase 4 (PDE4) regulation of proinflammatory cytokine and chemokine release from rheumatoid synovial membrane

Crilly, A., Robertson, S. E., Reilly, J. H., Gracie, J. A., Lai, W-Q., Leung, B. P., Life, P. F. & McInnes, I. B., Jun 2011, In : Annals of the Rheumatic Diseases. 70, 6, p. 1130-1137 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2010

Lipoma arborescens co-existing with psoriatic arthritis releases tumour necrosis factor alpha and matrix metalloproteinase 3

Fraser, A. R., Perry, M. E., Crilly, A., Reilly, J. H., Hueber, A. J. & McInnes, I. B., Apr 2010, In : Annals of the Rheumatic Diseases. 69, 4, p. 776-777

Research output: Contribution to journalLetter

14 Citations (Scopus)
2005

Disease association of two distinct interleukin-18 promoter polymorphisms in Caucasian rheumatoid arthritis patients

Gracie, J. A., Koyama, N., Murdoch, J., Field, M., McGarry, F., Crilly, A., Schobel, A., Madhok, R., Pons-Kühnemann, J., McInnes, I. B. & Möller, B., May 2005, In : Genes and Immunity. 6, 3, p. 211-6 6 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
2003

Analysis of the 5' flanking region of the interleukin 10 gene in patients with systemic sclerosis

Crilly, A., Hamilton, J., Clark, C. J., Jardine, A. & Madhok, R., 1 Nov 2003, In : Rheumatology. 42, 11, p. 1295-8 4 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

A novel anti-inflammatory role for simvastatin in inflammatory arthritis

Leung, B. P., Sattar, N., Crilly, A., Prach, M., McCarey, D. W., Payne, H., Madhok, R., Campbell, C., Gracie, J. A., Liew, F. Y. & McInnes, I. B., 1 Feb 2003, In : The Journal of Immunology. 170, 3, p. 1524-30 7 p.

Research output: Contribution to journalArticle

376 Citations (Scopus)
2002

Analysis of transforming growth factor beta1 gene polymorphisms in patients with systemic sclerosis

Crilly, A., Hamilton, J., Clark, C. J., Jardine, A. & Madhok, R., Aug 2002, In : Annals of the Rheumatic Diseases. 61, 8, p. 678-81 4 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)
2001

Investigation of novel polymorphisms within the 3' region of the IL-6 gene in patients with rheumatoid arthritis using Genescan analysis

Crilly, A., Bartlett, J. M. S., White, A., Stirling, D., Capell, H. & Madhok, R., Jan 2001, In : Cytokine. 13, 2, p. 109-12 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2000

Predictive value of interleukin 1 gene polymorphisms for surgery

Crilly, A., Maiden, N., Capell, H. A. & Madhok, R., 1 Sep 2000, In : Annals of the Rheumatic Diseases. 59, 9, p. 695-699 5 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
1999

Genotyping for disease associated HLA DR beta 1 alleles and the need for early joint surgery in rheumatoid arthritis: a quantitative evaluation

Crilly, A., Maiden, N., Capell, H. A. & Madhok, R., Feb 1999, In : Annals of the Rheumatic Diseases. 58, 2, p. 114-7 4 p.

Research output: Contribution to journalArticle

Open Access
23 Citations (Scopus)

Modification of the GeneScan 2500 fluorescent dye standard for accurate product sizing

Bartlett, J. M., Crilly, A., White, A. & Madhok, R., 15 Dec 1999, In : Molecular Biotechnology. 13, 3, p. 185-9 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
1997

Non-Hodgkin's lymphomas complicating Sjögren's syndrome: can Epstein Barr virus be implicated?

Jeffers, M., Crilly, A., Kerr, T., Richmond, J. & Madhok, R., 1997, In : Scandinavian Journal of Rheumatology. 26, 3, p. 180-3 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
1996

The relationship between weight loss and interleukin 6 in non-small-cell lung cancer

Scott, H. R., McMillan, D. C., Crilly, A., McArdle, C. S. & Milroy, R., Jun 1996, In : British Journal of Cancer. 73, 12, p. 1560-2 3 p.

Research output: Contribution to journalArticle

123 Citations (Scopus)
1995

Effect of cyclosporin A on interleukin-6 and soluble interleukin-2 receptor in patients with rheumatoid arthritis

Crilly, A., Kolta, S., Dougados, M., Sturrock, R. D., Amor, B., Capell, H. A. & Madhok, R., Feb 1995, In : Annals of the Rheumatic Diseases. 54, 2, p. 137-9 3 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Interleukin 6 (IL-6) and soluble IL-2 receptor levels in patients with rheumatoid arthritis treated with low dose oral methotrexate

Crilly, A., McInness, I. B., McDonald, A. G., Watson, J., Capell, H. A. & Madhok, R., Feb 1995, In : The Journal of Rheumatology. 22, 2, p. 224-6 3 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

The effect of auranofin and sulphasalazine therapy on circulating levels of interleukin 6 in rheumatoid arthritis patients

Crilly, A., Capell, H. A., Watson, J. & Madhok, R., Sep 1995, In : Clinical Rheumatology. 14, 5, p. 561-565 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
1994

Production of interleukin-6 by monocytes isolated from rheumatoid arthritis patients receiving second-line drug therapy

Crilly, A., Madhok, R., Watson, J., Capell, H. A. & Sturrock, R. D., Sep 1994, In : Clinical Rheumatology. 33, 9, p. 821-5 5 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

The effect of azathioprine on serum levels of interleukin 6 and soluble interleukin 2 receptor

Crilly, A., McInnes, I. B., Capell, H. A. & Madhok, R., 1994, In : Scandinavian Journal of Rheumatology. 23, 2, p. 87-91 5 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
1 Citation (Scopus)
1993

Gold therapy lowers serum interleukin 6 levels in rheumatoid arthritis

Madhok, R., Crilly, A., Murphy, E., Smith, J., Watson, J. & Capell, H. A., Apr 1993, In : Clinical Rheumatology. 20, 4, p. 630-3 4 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Serum concentrations of soluble interleukin 2 receptor in patients with rheumatoid arthritis: effect of second line drugs

Crilly, A., Madhok, R., Watson, J. & Capell, H. A., Jan 1993, In : Annals of the Rheumatic Diseases. 52, 1, p. 58-60 3 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Serum interleukin 6 levels in rheumatoid arthritis: correlations with clinical and laboratory indices of disease activity

Madhok, R., Crilly, A., Watson, J. & Capell, H. A., Mar 1993, In : Annals of the Rheumatic Diseases. 52, 3, p. 232-4 3 p.

Research output: Contribution to journalArticle

276 Citations (Scopus)
1992

IL-6 and soluble IL-2 receptor in rheumatoid arthritis patients treated with second line drugs

Watson, J., Crilly, A., Madhok, R., Capell, H. & Sturrock, R., May 1992, In : Biochemical Society Transactions. 20, 2, p. 138S

Research output: Contribution to journalMeeting Abstract

5 Citations (Scopus)

Interleukin-6 in scleroderma: comment on the article by Needleman et al

Crilly, A. & Madhok, R., Nov 1992, In : Arthritis and Rheumatism. 35, 11, p. 1402 1 p.

Research output: Contribution to journalLetter