Personal profile
Overview
After graduating with BSc Hons Chemistry from the 'old' Paisley College of Trechnology in 1986, I stayed on to carry out my PhD (Use of Laser Flash Photolysis in the study of Photodymanic Therapy) under the supervision of Prof T.G. Truscott. The highlight of this research was a Cancer Letts paper reporting the first observation of triplet excited transient states that underwent reaction with molecular oxygen following pulsed laser excitation of HpD in cellular enviroments. There then followed a three year post-doctoral stint with Prof M.A.J Rodgers at the Centre for Photochemical Sciences, Ohio, USA where I studied the more fundamental aspects of photo-oxidation mechanisms. These studies resulted in three J. Am. Chem. Soc. papers.
At that point I was contacted about an academic position that became available in Physical Chemistry at the now-called University of Paisley. I took up that position in late 1993 and started using photochemical reactions as a probe of the solvation properties and mechanistic influence of room temperature ionic liquids (RTILs). This resulted in several publications, among them 5 Chem Comms, two of which were highlighted as HOT papers and were feaured in Chemistry World as well as C & E news.
There then followed a period of particularly intensive teaching duties that had to be focussed on and developed. I taught the majority of BSc 1 Chemistry, Forensic Cases Studies, Pharmaceutical Science Case Studies, Introductory Chemistry for Health Science, Introductory Chemistry for Occupational Safety and Health, BSc2 Physical Chemistry labs and tutorials, BSc 3 Physical Chemistry for Pharmaceutical Science, as well as components of BSc3 and 4 physical chemistry. In addition I acted as module coordinator of up to 8 modules per year, including the Hons project module. Finally, over much of this time I sat on the local committee of the Royal Society of Chemistry.
In recent years (at the now-called University of the West of Scotland), an interest in modelling the opto-electronic properties of dyes and pigments has been developed. This involved developing methods to utilise molecular modelling software in the systematic manipulation of 3D molecular structure such that interaction energies, charge transport and optical properties of various rigorously defined dimer species could be computed.
This work has been presented in many national as well as international conferences over the years with particular highlights being invitations to present talks to the Am. Chem. Soc. (2003 & 2004) and E. M. R. S. (2015) conferences.
Overall, I would describe myself essentially as an active Physical Chemist with enthusiasm for teaching (and teaching myself about) the subject.
Finally, as a graduate of Paisley College of Technology, it is a genuine pleasure to be collaborating with (amongst others) a former student of University of Paisley who is supervising the PhD of one of my UWS hons students - thereby bridging all the institutional changes that the 'old' PCT has undergone over the last 30 years within a single research collaboration!
Area of academic expertise - outline
Reaction kinetics & mechanisms, photophysics & photochemistry, electrochemistry, UV-VIS absortion and fluorescence spectroscopy, laser flash photolysis and molecular modelling as applied to:
- Photo-oxidation mechanisms associated with (photo- and) chemotherapeutic agents.
- Understanding of the basic action and influence of room temperature ionic liquids (RTILs) on reaction rates and mechanisms involving both charged and neutral reacting species.
- Photophysics and photochemistry of dyes and pigments.
- Understanding of molecular structural factors responsible for the opto-electronic properties of crystalline dyes and pigments.
- The relationship between computed molecular vibrational properties and charge transport / chemical reactivity.
- The use of molecular modelling in developing structural identfication protocols and enviromental distribution of organic materials.
Current research activities
- Re-developing interest in the detailed role of RTILs in controlling mechanisms of charge transfer.
- Understanding the role of counter ion identity and location in systematic control of the opto-electronic properties of cationic dyes in their (quasi) crystalline state.
- Understanding the detailed relationship between molecular vibrational modes and (photo-) chemical reactivity.
Desired research direction
- broaden the applications of our molecular modelling studies via the improvement of our computer software and hardware.
- to develop a state of the art laser flash photolysis lab capable of supporting multiple users, collaborators and disciplines over this and local institutional(s).
- explore the links between computed vibrational spectra and experiment.
Target collaborative companies
- fujifilm
- 3M
- ultrafastsystems
Target collaborative organisations
- EPSRC
- Wellcome Trust
External positions
Post-Doctoral Research Fellow, Center for Photochemical Sciences
1990 → 1993
Keywords
- QD Chemistry
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
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Collaborations and top research areas from the last five years
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Detection of nitroaromatic and peroxide-based explosives with amine- and phosphine-functionalised diketopyrrolopyrroles
Warzecha, M., Morris, G., McLean, A. J., Calvo-Castro, J. & McHugh, C. J., 31 May 2023, In: ACS Applied Materials and Interfaces. 15, 23, p. 27915–27927 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Link opens in a new tab Citations (Scopus)53 Downloads (Pure) -
Development of a neutral diketopyrrolopyrrole phosphine oxide for the selective bioimaging of mitochondria at the nanomolar level
Abelha, T. F., Morris, G., Lima, S. M., Andrade, L. H. C., McLean, A. J., Alexander, C., Calvo-Castro, J. & McHugh, C. J., 9 Mar 2020, In: Chemistry - a European journal. 26, 14, p. 3173-3180 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Link opens in a new tab Citations (Scopus)31 Downloads (Pure) -
Rational design of phenothiazinium derivatives and photoantimicrobial drug discovery
Wainwright, M. & McLean, A., 31 Jan 2017, In: Dyes and Pigments. 136, p. 590-600 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Link opens in a new tab Citations (Scopus)185 Downloads (Pure) -
Impact of substituent effects on the Raman spectra of structurally related N-substituted diketopyrrolopyrroles.
Calvo-Castro, J., Warzecha, M., McLean, A. & McHugh, C., 1 Mar 2016, In: Vibrational Spectroscopy. 83, p. 8-16Research output: Contribution to journal › Article › peer-review
5 Link opens in a new tab Citations (Scopus) -
Intermolecular Interactions and Energetics in the Crystalline π–π Stacks and Associated Model Dimer Systems of Asymmetric Halogenated Diketopyrrolopyrroles
Calvo-castro, J., Warzecha, M., Oswald, I. D. H., Kennedy, A. R., Morris, G., Mclean, A. J. & Mchugh, C. J., 2 Mar 2016, In: Crystal Growth & Design. 16, 3, p. 1531-1542Research output: Contribution to journal › Article › peer-review
15 Link opens in a new tab Citations (Scopus)
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Glasgow Science Festival
McLean, A. (Contributor)
8 Jun 2017Activity: Other › Types of Public engagement and outreach - Festival/Exhibition
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Chemistry at Work
McLean, A. (Contributor)
20 Jun 2017Activity: Other › Types of Public engagement and outreach - Festival/Exhibition
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Systematic control of hole and electron charge transfer integrals through systematic structural variation in a series of crystalline diphenyldiketopyrrolopyrroles.
McLean, A. (Speaker)
12 May 2015Activity: Talk or presentation › Oral presentation