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Personal profile

Area of academic expertise - outline

Cardiovascular disease is the single leading cause of death and disability in the world (responsible for almost 1 in every 3 deaths). Dysfunction of endothelial cells, a cell type that lines the surface of every blood vessel, plays a critical role in the development and progression of cardiovascular disease but as yet we do not have effective therapeutic means to protect or restore activity of this key cell type. My research focuses on the role of endothelial cells as a regulator of vascular smooth muscle cell activity and how this can be is disrupted by the inflammatory conditions that occur in diseases such as obesity, diabetes mellitus, preeclampsia and rheumatoid arthritis. Understanding more about how endothelial cells become dysfunctional will greatly enhance our insight into the cellular processes that underlie the cardiovascular disease and help find means to prevent the its devastating consequences, such as heart attack and stroke.

I have established an ex vivo vascular assessment suite allowing the determination of both macro- and micro-vascular reactivity i.e. real-time recording of contraction and relaxation of isolated blood vessels. The key advantage of ex vivo analysis of vascular reactivity is that the blood vessel is free from hormonal or neural influence and in an environment which allows for accurate probing of cellular pathways. Furthermore, through my partnership with the Centre of Musculoskeletal Science at Glasgow University, we can also determine blood flow in vivo with use of a laser Doppler technique. Moreover, access to techniques such as PCR, immunohistochemistry, western blotting and ELISA allows for a multi-faceted multi-disciplinary approach to exploring vascular dysfunction.

Current research activities

My current research investigates the mechanisms underlying vascular dysfunction found in several diverse disorders. Specifically we are exploring the role of the angiotensin 2 type 1 receptor as a mediator of vascular dysfunction found in rheumatoid arthritis. Furthermore we are analysing the role of adipose tissue as a regulator of vascular reactivity and how with can be modified by proteinase-activated receptor 2 in conditions of obesity. In addition we are analysing human placental artery function in relation to interleukin levels to investigate potential a route by which preeclampsia may develop. Moreover we are examining flavonoids and other dietary supplements for their putative protective action against the detrimental influence of glucose vascular reactivity.

Desired research direction

My aim is to garner further insight into the cellular mechanisms underlying vascular disorder and to utilise this knowledge to highlight novel routes of therapy and, along with industrial partners, develop targeted pharmaceutical interventions to prevent or alleviate this most devastating of diseases.

Keywords

  • QP Physiology
  • Cardiovascular disease
  • Endothelium
  • Nitric Oxide
  • AT1R
  • Inflammation

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Research Output

  • 5 Meeting Abstract
  • 5 Article
  • 3 Poster
  • 2 Conference contribution

Adipose tissue enhances nitrite-mediated vascular relaxation in conditions of hypoxia

MacKenzie, A., Akhtar, A., Sculthorpe, N. & Easton, C., 30 Jun 2020, In : British Journal of Pharmacology. 177, 11, p. 2609-2610 2 p., P203.

Research output: Contribution to journalMeeting Abstract

  • Enhanced airway smooth muscle relaxation via proteinase activated receptor 2

    Black, K., MacKenzie, A., Dunning, L., Crilly, A., Brzeszczynska, J., McGarvey, L., Thornbury, K., Goodyear, C. S., Lockhart, J. C. & Litherland, G. J., 22 Nov 2019, In : Irish Journal of Medical Science. 188, SUPPL 10, p. 286-286 1 p.

    Research output: Contribution to journalMeeting Abstract

    Proteinase activated receptor 2 (PAR2) modulation of murine airway function

    Black, K., MacKenzie, A., Dunning, L., Crilly, A., Brzeszczyńska, J., McGarvey, L., Thornbury, K., Goodyear, C. S., Lockhart, J. & Litherland, G., 10 Sep 2019.

    Research output: Contribution to conferencePoster

    Open Access
    File
  • 7 Downloads (Pure)

    Assessment of the effects of exercise on a murine model of OA

    Huesa, C., Dunning, L., Macdougall, K., Ortiz, A., Villaluz, M. M., Fegen, M., Crilly, A., Litherland, G., MacKenzie, A., van't Hof, R., Goodyear, C. & Lockhart, J., 30 Apr 2018, In : Osteoarthritis and Cartilage. 26, Supplement 1, p. s68 1 p.

    Research output: Contribution to journalMeeting Abstract

  • Proteinase activated receptor 2 (PAR2) modulation of airway smooth muscle function

    Black, K., MacKenzie, A., Dunning, L., Crilly, A., McGarvey, L., Thornbury, K., Goodyear, C., Lockhart, J. & Litherland, G., 8 Oct 2018, In : Irish Journal of Medical Science. 187, Supplement 8, p. S249-S249 1 p.

    Research output: Contribution to journalMeeting Abstract

    Open Access
    File
  • 21 Downloads (Pure)

    Prizes

  • SAUWS Big Award nominee for LECTURER OF THE YEAR

    MacKenzie, Andrew (Recipient), 2019

    Prize: Prize (including medals and awards)

    UWS STARS Award nominee for OUTSTANDING RESEARCH

    MacKenzie, Andrew (Recipient), 2016

    Prize: Prize (including medals and awards)

    UWS STARS Award nominee for OUTSTANDING TEACHING

    MacKenzie, Andrew (Recipient), 2017

    Prize: Prize (including medals and awards)

    UWS STARS Awards finalist for OUTSTANDING TEACHING

    MacKenzie, Andrew (Recipient), 2019

    Prize: Prize (including medals and awards)

    Activities

    Microvascular Research (Journal)

    Andrew MacKenzie (Peer reviewer)

    Jun 2020

    Activity: Publication peer-review and editorial workPublication peer-review

    Chair of PhD viva examination UWS

    Andrew MacKenzie (Examiner)

    Mar 2020

    Activity: Examination

    PhD Internal Examiner UWS

    Andrew MacKenzie (Examiner)

    14 Aug 2019

    Activity: Examination

    Journal of Clinical Medicine (Journal)

    Andrew MacKenzie (Peer reviewer)

    2019

    Activity: Publication peer-review and editorial workPublication peer-review

    Glasgow Science Festival - “Smashing Science @UWS"

    Andrew MacKenzie (Participant)

    6 Jun 2019

    Activity: OtherTypes of Public engagement and outreach - Festival/Exhibition

    Profiles